hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01456
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CHD8 | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | UniProt NCBI |
| TCF7L2 | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | UniProt NCBI |
| IKZF5 | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4336 | 0.0028706736774 | 0.666666666667 | CHD8 TCF7L2 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 0.00357470816736 | 0.666666666667 | CHD8 TCF7L2 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:04310 | 0.00477455273147 | 0.666666666667 | CHD8 TCF7L2 | Wnt signaling pathway |
| REAC:R-HSA-3769402 | 0.00495307159189 | 0.666666666667 | CHD8 TCF7L2 | Deactivation of the beta-catenin transactivating complex |
| WP:WP428 | 0.005414047126 | 0.666666666667 | CHD8 TCF7L2 | Wnt Signaling |
| CORUM:3155 | 0.0499776345577 | 0.333333333333 | TCF7L2 | TFC4-CTNNB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TCF7L2 | IKZF5 | 0.986 | 0.901 | bioplex (IKZF5) bioplex_WMM |
| CHD8 | IKZF5 | 0.882 | 0.817 | bioplex (IKZF5) bioplex_WMM |
| CHD8 | TCF7L2 | 0.008 | 0.042 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01456 has an average edge precision of 0.587 which is ranked 2005 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CHD8 | HuMAP2_00070 HuMAP2_01456 |
| TCF7L2 | HuMAP2_01456 HuMAP2_05792 |
| IKZF5 | HuMAP2_01456 HuMAP2_04537 HuMAP2_05792 |