hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01472
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| XAB2 | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | UniProt NCBI |
| CDC40 | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | UniProt NCBI |
| CRNKL1 | Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) | UniProt NCBI |
| CWC15 | Spliceosome-associated protein CWC15 homolog | UniProt NCBI |
| SYF2 | Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29) | UniProt NCBI |
| RBM22 | Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16) | UniProt NCBI |
| SNW1 | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | UniProt NCBI |
| ISY1 | Pre-mRNA-splicing factor ISY1 homolog | UniProt NCBI |
| PPIE | Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) | UniProt NCBI |
| AQR | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | UniProt NCBI |
| ZNF830 | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | UniProt NCBI |
| CCDC12 | Coiled-coil domain-containing protein 12 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 7.87995182034e-21 | 0.916666666667 | SNW1 CRNKL1 AQR PPIE RBM22 CDC40 CCDC12 XAB2 CWC15 ISY1 SYF2 | Spliceosome |
| CORUM:1181 | 3.46190765209e-20 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | C complex spliceosome |
| GO:0005684 | 1.41492946548e-19 | 0.916666666667 | SNW1 CRNKL1 AQR PPIE RBM22 CDC40 CCDC12 XAB2 CWC15 ISY1 SYF2 | U2-type spliceosomal complex |
| GO:0071007 | 1.58125233629e-18 | 0.75 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 SYF2 | U2-type catalytic step 2 spliceosome |
| CORUM:351 | 1.56628359335e-17 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | Spliceosome |
| GO:0071013 | 5.39035441012e-17 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | catalytic step 2 spliceosome |
| GO:0005681 | 9.90805152884e-17 | 0.916666666667 | SNW1 CRNKL1 AQR PPIE RBM22 CDC40 CCDC12 XAB2 CWC15 ISY1 SYF2 | spliceosomal complex |
| REAC:R-HSA-72163 | 7.19752833666e-16 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 1.12869686625e-15 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | mRNA Splicing |
| REAC:R-HSA-72203 | 1.22488536702e-14 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000377 | 4.48542978754e-11 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 4.48542978754e-11 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | mRNA splicing, via spliceosome |
| GO:0000375 | 4.94094943753e-11 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | RNA splicing, via transesterification reactions |
| GO:0008380 | 2.50692869463e-10 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | RNA splicing |
| REAC:R-HSA-8953854 | 3.55924031573e-10 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | Metabolism of RNA |
| GO:0006397 | 5.2265368275e-10 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | mRNA processing |
| GO:1990904 | 2.94570954588e-09 | 0.916666666667 | SNW1 CRNKL1 AQR PPIE RBM22 CDC40 CCDC12 XAB2 CWC15 ISY1 SYF2 | ribonucleoprotein complex |
| GO:0000974 | 8.32392487246e-09 | 0.416666666667 | CRNKL1 RBM22 SYF2 XAB2 ISY1 | Prp19 complex |
| GO:0071014 | 8.32392487246e-09 | 0.416666666667 | CRNKL1 CCDC12 SYF2 XAB2 ISY1 | post-mRNA release spliceosomal complex |
| REAC:R-HSA-6781823 | 8.82668050887e-08 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | Formation of TC-NER Pre-Incision Complex |
| GO:0016071 | 1.79871297669e-07 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | mRNA metabolic process |
| REAC:R-HSA-6782210 | 2.3350629408e-07 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 2.52865771611e-07 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | Dual incision in TC-NER |
| GO:0006396 | 3.97261979911e-07 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | RNA processing |
| REAC:R-HSA-6781827 | 6.42994649575e-07 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696398 | 3.68111782873e-06 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | Nucleotide Excision Repair |
| GO:1902494 | 3.03218970315e-05 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | catalytic complex |
| GO:0006283 | 9.48856045139e-05 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | transcription-coupled nucleotide-excision repair |
| GO:0006289 | 0.000602356847461 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | nucleotide-excision repair |
| REAC:R-HSA-73894 | 0.000761584990388 | 0.416666666667 | ZNF830 AQR PPIE ISY1 XAB2 | DNA Repair |
| CORUM:0000000 | 0.00103875568224 | 0.833333333333 | SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | CORUM root |
| GO:0003723 | 0.00566001652275 | 0.75 | CRNKL1 PPIE CDC40 ISY1 AQR RBM22 SNW1 CWC15 SYF2 | RNA binding |
| GO:0044428 | 0.00949571436824 | 1.0 | ZNF830 SNW1 CRNKL1 AQR PPIE RBM22 CDC40 CCDC12 XAB2 CWC15 ISY1 SYF2 | nuclear part |
| GO:0005654 | 0.0205713159985 | 0.916666666667 | ZNF830 SNW1 CRNKL1 PPIE RBM22 CDC40 AQR XAB2 CWC15 ISY1 SYF2 | nucleoplasm |
| KEGG:00000 | 0.0230781193683 | 0.916666666667 | SNW1 CRNKL1 AQR PPIE RBM22 CDC40 CCDC12 XAB2 CWC15 ISY1 SYF2 | KEGG root term |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ISY1 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (CRNKL1) Malo fraction |
| ISY1 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| CRNKL1 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo gupta_WMM fraction treiber_WMM |
| PPIE | ISY1 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru Malo fraction |
| PPIE | XAB2 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM Malo fraction |
| PPIE | AQR | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM Malo fraction |
| PPIE | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo fraction |
| XAB2 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| CRNKL1 | XAB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo gupta_WMM fraction treiber_WMM |
| ISY1 | XAB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| SNW1 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SNW1) gupta_WMM fraction treiber_WMM |
| CDC40 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) fraction treiber_WMM |
| SNW1 | CCDC12 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SNW1) fraction |
| SNW1 | CDC40 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SNW1) fraction treiber_WMM |
| PPIE | CCDC12 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM hein (CCDC12) fraction |
| CRNKL1 | SYF2 | 1.0 | 0.949 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM hein (CRNKL1) |
| SNW1 | SYF2 | 1.0 | 0.949 | hein_WMM bioplex (SYF2) bioplex_WMM Guru youn_WMM hein (SNW1) fraction |
| PPIE | ZNF830 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM youn_WMM |
| CDC40 | CCDC12 | 0.999 | 0.948 | hein_WMM bioplex_WMM Guru youn_WMM hein (CCDC12) fraction |
| CRNKL1 | CCDC12 | 0.999 | 0.948 | hein_WMM bioplex_WMM Guru youn_WMM hein (CCDC12,CRNKL1) fraction |
| SNW1 | PPIE | 0.998 | 0.935 | hein_WMM bioplex (PPIE) bioplex_WMM youn_WMM hein (SNW1) |
| SNW1 | XAB2 | 0.996 | 0.928 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) gupta_WMM treiber_WMM |
| CCDC12 | AQR | 0.987 | 0.901 | hein_WMM bioplex_WMM Guru youn_WMM hein (CCDC12) fraction |
| SNW1 | ISY1 | 0.967 | 0.879 | hein_WMM bioplex_WMM hein (SNW1) |
| XAB2 | CCDC12 | 0.967 | 0.878 | hein_WMM bioplex_WMM youn_WMM hein (CCDC12) |
| SNW1 | CWC15 | 0.946 | 0.857 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) gupta_WMM |
| ISY1 | CCDC12 | 0.943 | 0.856 | hein_WMM bioplex_WMM hein (CCDC12) |
| CRNKL1 | CWC15 | 0.887 | 0.818 | hein_WMM bioplex_WMM youn_WMM hein (CRNKL1) gupta_WMM |
| SNW1 | AQR | 0.869 | 0.803 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) gupta_WMM |
| AQR | ZNF830 | 0.82 | 0.773 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| CDC40 | AQR | 0.772 | 0.751 | hein_WMM bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| SYF2 | AQR | 0.77 | 0.749 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| XAB2 | ZNF830 | 0.743 | 0.739 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| SNW1 | RBM22 | 0.742 | 0.739 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) treiber_WMM |
| CDC40 | ISY1 | 0.723 | 0.732 | hein_WMM bioplex_WMM Guru fraction |
| CDC40 | XAB2 | 0.719 | 0.73 | hein_WMM bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| XAB2 | SYF2 | 0.668 | 0.701 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| PPIE | SYF2 | 0.633 | 0.682 | hein_WMM bioplex (PPIE,SYF2) bioplex_WMM youn_WMM fraction |
| ISY1 | SYF2 | 0.466 | 0.604 | hein_WMM bioplex (SYF2) bioplex_WMM |
| CDC40 | SYF2 | 0.435 | 0.579 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| SYF2 | CCDC12 | 0.34 | 0.528 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| CRNKL1 | ZNF830 | 0.309 | 0.502 | hein_WMM bioplex_WMM youn_WMM hein (CRNKL1) gupta_WMM |
| PPIE | RBM22 | 0.078 | 0.352 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| SYF2 | RBM22 | 0.072 | 0.354 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| AQR | RBM22 | 0.058 | 0.323 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| PPIE | CDC40 | 0.053 | 0.301 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| ISY1 | ZNF830 | 0.044 | 0.28 | hein_WMM bioplex_WMM fraction |
| SYF2 | CWC15 | 0.033 | 0.245 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| CDC40 | RBM22 | 0.025 | 0.214 | hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM |
| XAB2 | RBM22 | 0.022 | 0.205 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CRNKL1 | RBM22 | 0.022 | 0.199 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ISY1 | RBM22 | 0.019 | 0.186 | hein_WMM bioplex_WMM WMM_only |
| XAB2 | CWC15 | 0.018 | 0.178 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PPIE | CWC15 | 0.017 | 0.166 | hein_WMM bioplex (PPIE) bioplex_WMM youn_WMM |
| CCDC12 | RBM22 | 0.014 | 0.144 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CWC15 | AQR | 0.013 | 0.142 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC40 | CWC15 | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CCDC12 | ZNF830 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SYF2 | ZNF830 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CDC40 | ZNF830 | 0.01 | 0.139 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SNW1 | ZNF830 | 0.009 | 0.108 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CWC15 | ZNF830 | 0.009 | 0.108 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ZNF830 | RBM22 | 0.009 | 0.11 | bioplex_WMM youn_WMM WMM_only |
| CWC15 | CCDC12 | 0.008 | 0.074 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ISY1 | CWC15 | 0.008 | 0.045 | hein_WMM bioplex_WMM WMM_only |
| CWC15 | RBM22 | 0.007 | 0.004 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01472 has an average edge precision of 0.605 which is ranked 1913 out of all 6965 complexes.
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