hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01473
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | UniProt NCBI |
| KIFC1 | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | UniProt NCBI |
| KPNA1 | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | UniProt NCBI |
| RNGTT | mRNA-capping enzyme (HCAP1) (HCE) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] | UniProt NCBI |
| NUP153 | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162587 | 6.58288761159e-06 | 0.8 | NUP153 KPNA1 RNGTT NUP50 | HIV Life Cycle |
| REAC:R-HSA-168271 | 8.88541585136e-06 | 0.6 | NUP153 KPNA1 NUP50 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-180910 | 1.10096191184e-05 | 0.6 | NUP153 KPNA1 NUP50 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-176033 | 1.47907161009e-05 | 0.6 | NUP153 KPNA1 NUP50 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-168276 | 2.10552596086e-05 | 0.6 | NUP153 KPNA1 NUP50 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168253 | 2.28576897279e-05 | 0.6 | NUP153 KPNA1 NUP50 | Host Interactions with Influenza Factors |
| REAC:R-HSA-162906 | 3.61955824501e-05 | 0.8 | NUP153 KPNA1 RNGTT NUP50 | HIV Infection |
| REAC:R-HSA-1169408 | 0.00012942105654 | 0.6 | NUP153 KPNA1 NUP50 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.000175005907139 | 0.6 | NUP153 KPNA1 NUP50 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-5663205 | 0.000241108816086 | 0.8 | NUP153 KPNA1 RNGTT NUP50 | Infectious disease |
| REAC:R-HSA-162909 | 0.000793200049211 | 0.6 | NUP153 KPNA1 NUP50 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.00102865345201 | 0.6 | NUP153 NUP50 RNGTT | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168255 | 0.00114945154681 | 0.6 | NUP153 KPNA1 NUP50 | Influenza Life Cycle |
| REAC:R-HSA-168254 | 0.00141854667829 | 0.6 | NUP153 KPNA1 NUP50 | Influenza Infection |
| REAC:R-HSA-913531 | 0.00230616063943 | 0.6 | NUP153 KPNA1 NUP50 | Interferon Signaling |
| REAC:R-HSA-170822 | 0.00508433997358 | 0.4 | NUP50 NUP153 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168333 | 0.00508433997358 | 0.4 | NUP50 NUP153 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 0.00508433997358 | 0.4 | NUP50 NUP153 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-5619107 | 0.00508433997358 | 0.4 | NUP50 NUP153 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-159227 | 0.00584945327803 | 0.4 | NUP50 NUP153 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180746 | 0.00584945327803 | 0.4 | NUP50 NUP153 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 0.00625202329777 | 0.4 | NUP50 NUP153 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 0.00625202329777 | 0.4 | NUP50 NUP153 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 0.00625202329777 | 0.4 | NUP50 NUP153 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 0.00666792835349 | 0.4 | NUP50 NUP153 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 0.00709716303977 | 0.4 | NUP50 NUP153 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 0.0075397219523 | 0.4 | NUP50 NUP153 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-159231 | 0.00894729002053 | 0.4 | NUP50 NUP153 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.00944309181669 | 0.4 | NUP50 NUP153 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.0104745816743 | 0.4 | NUP50 NUP153 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4570464 | 0.0115592172394 | 0.4 | NUP50 NUP153 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4615885 | 0.0115592172394 | 0.4 | NUP50 NUP153 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-1643685 | 0.0116415059931 | 0.8 | NUP153 KPNA1 RNGTT NUP50 | Disease |
| REAC:R-HSA-2980766 | 0.0132857243802 | 0.4 | NUP50 NUP153 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 0.0164283536306 | 0.4 | NUP50 NUP153 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.0164283536306 | 0.4 | NUP50 NUP153 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 0.019180674733 | 0.4 | NUP50 NUP153 | tRNA processing in the nucleus |
| GO:0075733 | 0.022411068229 | 0.6 | NUP153 KPNA1 NUP50 | intracellular transport of virus |
| GO:0046794 | 0.0264291737868 | 0.6 | NUP153 KPNA1 NUP50 | transport of virus |
| REAC:R-HSA-4551638 | 0.0278384291304 | 0.4 | NUP50 NUP153 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3371453 | 0.0278384291304 | 0.4 | NUP50 NUP153 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.0287045163353 | 0.4 | NUP50 NUP153 | Glycolysis |
| REAC:R-HSA-159236 | 0.0304761248659 | 0.4 | NUP50 NUP153 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 0.0332320424718 | 0.4 | NUP50 NUP153 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-72202 | 0.0390979640759 | 0.4 | NUP50 NUP153 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-5619102 | 0.0422076786847 | 0.4 | NUP50 NUP153 | SLC transporter disorders |
| REAC:R-HSA-70326 | 0.0443461879505 | 0.4 | NUP50 NUP153 | Glucose metabolism |
| GO:1902579 | 0.0472676873043 | 0.6 | NUP153 KPNA1 NUP50 | multi-organism localization |
| GO:0044766 | 0.0472676873043 | 0.6 | NUP153 KPNA1 NUP50 | multi-organism transport |
| REAC:R-HSA-3371556 | 0.0476518941102 | 0.4 | NUP50 NUP153 | Cellular response to heat stress |
| KEGG:03013 | 0.0489206453689 | 0.4 | NUP50 NUP153 | RNA transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP50 | NUP153 | 1.0 | 0.949 | hein_WMM bioplex (NUP50) bioplex_WMM Guru boldt youn_WMM hein (NUP153) gupta_WMM fraction boldt_WMM |
| NUP50 | KIFC1 | 1.0 | 0.949 | hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KIFC1) gupta_WMM |
| NUP50 | RNGTT | 0.986 | 0.901 | youn (RNGTT) bioplex (NUP50,RNGTT) bioplex_WMM boldt youn_WMM boldt_WMM |
| KPNA1 | NUP50 | 0.894 | 0.82 | hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KPNA1) gupta_WMM treiber_WMM |
| NUP153 | KIFC1 | 0.024 | 0.21 | hein_WMM bioplex_WMM youn_WMM hein (KIFC1,NUP153) gupta_WMM |
| KPNA1 | KIFC1 | 0.008 | 0.065 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NUP153 | RNGTT | 0.008 | 0.041 | youn (RNGTT) bioplex_WMM boldt youn_WMM boldt_WMM |
| KPNA1 | RNGTT | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only |
| RNGTT | KIFC1 | 0.003 | 0.007 | youn (RNGTT) bioplex_WMM youn_WMM fraction |
| KPNA1 | NUP153 | 0.0 | 0.009 | hein_WMM bioplex_WMM youn_WMM hein (NUP153) gupta_WMM |
Images
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Complex HuMAP2_01473 has an average edge precision of 0.396 which is ranked 3370 out of all 6965 complexes.
Related Complexes