hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01476
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | UniProt NCBI |
| EEF1AKNMT | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | UniProt NCBI |
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | UniProt NCBI |
| EML2 | Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2) | UniProt NCBI |
| PFAS | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) | UniProt NCBI |
| PPAT | Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065676 | 0.000316419251483 | 0.285714285714 | SAE1 SUMO2 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3065678 | 0.000664182971726 | 0.285714285714 | SAE1 SUMO2 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 0.00142229359687 | 0.285714285714 | SAE1 SUMO2 | Processing and activation of SUMO |
| REAC:R-HSA-73817 | 0.00208509668734 | 0.285714285714 | PFAS PPAT | Purine ribonucleoside monophosphate biosynthesis |
| WP:WP4224 | 0.00210605462929 | 0.285714285714 | PFAS PPAT | Purine metabolism |
| REAC:R-HSA-8956320 | 0.00331497172198 | 0.285714285714 | PFAS PPAT | Nucleobase biosynthesis |
| CORUM:5756 | 0.0499886427319 | 0.142857142857 | SAE1 | SUA1-UBA2 complex |
| CORUM:7186 | 0.0499886427319 | 0.142857142857 | GCLC | Glutamate-cysteine ligase |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SAE1 | SUMO2 | 0.605 | 0.672 | hein_WMM bioplex_WMM youn_WMM hein (SAE1) gupta_WMM fraction |
| SAE1 | EEF1AKNMT | 0.179 | 0.438 | bioplex_WMM fraction |
| GCLC | SAE1 | 0.031 | 0.238 | fraction |
| PFAS | SUMO2 | 0.031 | 0.238 | bioplex_WMM youn_WMM gupta_WMM fraction |
| PFAS | PPAT | 0.028 | 0.231 | bioplex (PPAT) bioplex_WMM youn_WMM fraction |
| EML2 | PFAS | 0.027 | 0.225 | fraction |
| EML2 | SUMO2 | 0.009 | 0.093 | fraction |
| SUMO2 | EEF1AKNMT | 0.007 | 0.0 | bioplex_WMM WMM_only |
| PPAT | SAE1 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| GCLC | SUMO2 | 0.005 | 0.009 | bioplex (GCLC) |
| PPAT | EEF1AKNMT | 0.005 | 0.014 | bioplex_WMM WMM_only |
| PFAS | EEF1AKNMT | 0.004 | 0.009 | bioplex_WMM WMM_only |
| EML2 | PPAT | 0.0 | 0.01 | fraction |
| GCLC | PFAS | 0.0 | 0.01 | fraction |
| EML2 | GCLC | 0.0 | 0.009 | fraction |
| PFAS | SAE1 | 0.0 | 0.0 | bioplex_WMM youn_WMM gupta_WMM fraction |
| PPAT | SUMO2 | 0.0 | 0.001 | bioplex_WMM Guru youn_WMM fraction |
Images
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Complex HuMAP2_01476 has an average edge precision of 0.129 which is ranked 6831 out of all 6965 complexes.
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