hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01477
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BAD | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | UniProt NCBI |
| BCL2L1 | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | UniProt NCBI |
| TRMO | tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) | UniProt NCBI |
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| BCL2L11 | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | UniProt NCBI |
| BCL2L15 | Bcl-2-like protein 15 (Bcl2-L-15) | UniProt NCBI |
| BCL2 | Apoptosis regulator Bcl-2 | UniProt NCBI |
| RHPN2 | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111453 | 7.62190495696e-10 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| REAC:R-HSA-109606 | 1.38087801691e-06 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | Intrinsic Pathway for Apoptosis |
| WP:WP254 | 1.85353746388e-06 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | Apoptosis |
| KEGG:01521 | 1.86107984529e-06 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP1772 | 2.828375191e-06 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | Apoptosis Modulation and Signaling |
| WP:WP3872 | 5.84319763985e-06 | 0.375 | BCL2L15 BCL2 BCL2L1 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| KEGG:04210 | 1.55036637537e-05 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | Apoptosis |
| KEGG:04215 | 1.9719716795e-05 | 0.375 | BCL2L11 BCL2 BCL2L1 | Apoptosis - multiple species |
| WP:WP2447 | 4.30438949337e-05 | 0.375 | BAD BCL2 BCL2L1 | Amyotrophic lateral sclerosis (ALS) |
| WP:WP286 | 5.85165564524e-05 | 0.375 | BAD BCL2 BCL2L1 | IL-3 Signaling Pathway |
| REAC:R-HSA-114452 | 7.27251966908e-05 | 0.375 | BAD BCL2 BCL2L11 | Activation of BH3-only proteins |
| WP:WP3611 | 8.25479109351e-05 | 0.375 | BCL2L11 BCL2 BCL2L1 | Photodynamic therapy-induced AP-1 survival signaling. |
| KEGG:05014 | 0.000100614247911 | 0.375 | BAD BCL2 BCL2L1 | Amyotrophic lateral sclerosis (ALS) |
| REAC:R-HSA-844455 | 0.000134251754877 | 0.25 | BCL2 BCL2L1 | The NLRP1 inflammasome |
| GO:2001244 | 0.00013940565471 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | positive regulation of intrinsic apoptotic signaling pathway |
| REAC:R-HSA-109581 | 0.000191649495964 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | Apoptosis |
| REAC:R-HSA-5357801 | 0.000205619873895 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | Programmed Cell Death |
| GO:0001836 | 0.000208985203536 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | release of cytochrome c from mitochondria |
| KEGG:01524 | 0.00028662242245 | 0.375 | BAD BCL2 BCL2L1 | Platinum drug resistance |
| WP:WP4216 | 0.000289209668874 | 0.375 | BAD BCL2 BCL2L11 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05210 | 0.000424534845834 | 0.375 | BAD BCL2 BCL2L11 | Colorectal cancer |
| WP:WP4172 | 0.000450048304229 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | PI3K-Akt Signaling Pathway |
| KEGG:04151 | 0.000509455935862 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | PI3K-Akt signaling pathway |
| KEGG:05145 | 0.000640628756697 | 0.375 | BAD BCL2 BCL2L1 | Toxoplasmosis |
| GO:0046902 | 0.000716150529716 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | regulation of mitochondrial membrane permeability |
| WP:WP710 | 0.000913812823555 | 0.375 | BAD BCL2 BCL2L11 | DNA Damage Response (only ATM dependent) |
| GO:0090559 | 0.00114109330922 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | regulation of membrane permeability |
| KEGG:05162 | 0.00161755205348 | 0.375 | BAD BCL2 BCL2L1 | Measles |
| KEGG:04140 | 0.00181393374031 | 0.375 | BAD BCL2 BCL2L1 | Autophagy - animal |
| WP:WP3657 | 0.00194639986227 | 0.25 | BCL2 BCL2L1 | Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex |
| KEGG:05200 | 0.00285664338154 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | Pathways in cancer |
| WP:WP205 | 0.00293552516575 | 0.25 | BAD BCL2L1 | IL-7 Signaling Pathway |
| MIRNA:hsa-miR-16-1-3p | 0.00361849354578 | 0.375 | BCL2L11 BCL2 TRMO | hsa-miR-16-1-3p |
| GO:0008637 | 0.00447936876688 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | apoptotic mitochondrial changes |
| REAC:R-HSA-111447 | 0.00468368688758 | 0.25 | BAD BCL2 | Activation of BAD and translocation to mitochondria |
| KEGG:05170 | 0.0060206924582 | 0.375 | BAD BCL2 BCL2L1 | Human immunodeficiency virus 1 infection |
| WP:WP3981 | 0.00668996541081 | 0.25 | BAD BCL2 | miRNA regulation of prostate cancer signaling pathways |
| MIRNA:hsa-miR-3120-3p | 0.006752774316 | 0.375 | BCL2L11 BCL2L1 RHPN2 | hsa-miR-3120-3p |
| REAC:R-HSA-622312 | 0.00761952471968 | 0.25 | BCL2 BCL2L1 | Inflammasomes |
| WP:WP3941 | 0.00842941151014 | 0.25 | BAD BCL2 | Oxidative Damage |
| GO:2001235 | 0.00894888598316 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | positive regulation of apoptotic signaling pathway |
| GO:0007006 | 0.00928778966369 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | mitochondrial membrane organization |
| GO:2001242 | 0.00963619067435 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | regulation of intrinsic apoptotic signaling pathway |
| WP:WP364 | 0.0108828459268 | 0.25 | BAD BCL2L1 | IL-6 signaling pathway |
| WP:WP1971 | 0.0114106486825 | 0.25 | BAD BCL2 | Integrated Cancer Pathway |
| WP:WP4008 | 0.0114106486825 | 0.25 | BAD BCL2 | NO/cGMP/PKG mediated Neuroprotection |
| GO:0005741 | 0.0146226489414 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | mitochondrial outer membrane |
| GO:0001844 | 0.0184623087477 | 0.375 | BAD BCL2 BCL2L11 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| WP:WP304 | 0.0193921266924 | 0.25 | BAD BCL2 | Kit receptor signaling pathway |
| GO:0031968 | 0.0200720668583 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | organelle outer membrane |
| GO:0019867 | 0.0206899822098 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | outer membrane |
| GO:0010821 | 0.0233046326659 | 0.5 | BCL2L1 BAD BCL2 BCL2L11 | regulation of mitochondrion organization |
| KEGG:04115 | 0.0240649309102 | 0.25 | BCL2 BCL2L1 | p53 signaling pathway |
| WP:WP1438 | 0.0271826439906 | 0.125 | BCL2 | Influenza A virus infection |
| KEGG:05212 | 0.029607581241 | 0.25 | BAD BCL2L1 | Pancreatic cancer |
| GO:0090199 | 0.0301968453576 | 0.375 | BAD BCL2L1 BCL2L11 | regulation of release of cytochrome c from mitochondria |
| KEGG:05220 | 0.0321551626916 | 0.25 | BAD BCL2L1 | Chronic myeloid leukemia |
| WP:WP2034 | 0.0338475396753 | 0.25 | BAD BCL2L1 | Leptin signaling pathway |
| WP:WP4298 | 0.034765517806 | 0.25 | BCL2 BCL2L1 | Viral Acute Myocarditis |
| KEGG:04064 | 0.0366297345347 | 0.25 | BCL2 BCL2L1 | NF-kappa B signaling pathway |
| KEGG:05168 | 0.0400163527282 | 0.375 | BAD BCL2 BCL2L1 | Herpes simplex virus 1 infection |
| WP:WP4263 | 0.0425415333003 | 0.25 | BAD BCL2L1 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.0446052271652 | 0.25 | BAD BCL2L11 | ErbB Signaling Pathway |
| KEGG:01522 | 0.0474744022862 | 0.25 | BAD BCL2 | Endocrine resistance |
| KEGG:05215 | 0.0474744022862 | 0.25 | BAD BCL2 | Prostate cancer |
| WP:WP231 | 0.0477902143581 | 0.25 | BAD BCL2L1 | TNF alpha Signaling Pathway |
| KEGG:05222 | 0.0495932456701 | 0.25 | BCL2 BCL2L1 | Small cell lung cancer |
| CORUM:1062 | 0.0497224828424 | 0.125 | BCL2 | BAR-BCL2-CASP8 complex |
| CORUM:5526 | 0.0497224828424 | 0.125 | BCL2 | CALM1-FKBP38-BCL2 complex |
| CORUM:7275 | 0.0497224828424 | 0.125 | BCL2 | BCL2-CISD2 complex |
| CORUM:5811 | 0.0497224828424 | 0.125 | BCL2 | p53-BCL2 complex |
| CORUM:5812 | 0.0497224828424 | 0.125 | BCL2L1 | p53-BCL2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BAD | BCL2L1 | 0.976 | 0.892 | bioplex (BCL2L1) bioplex_WMM |
| BCL2 | BCL2L1 | 0.831 | 0.778 | bioplex (BCL2L1) bioplex_WMM |
| BCL2L11 | BCL2L1 | 0.773 | 0.752 | bioplex (BCL2L1,BCL2L11) bioplex_WMM |
| BCL2L11 | RHPN2 | 0.731 | 0.736 | bioplex (BCL2L11) bioplex_WMM |
| RHPN2 | TRMO | 0.149 | 0.41 | bioplex (TRMO) bioplex_WMM |
| BCL2 | BCL2L11 | 0.066 | 0.35 | bioplex (BCL2L11) bioplex_WMM |
| APTX | BAD | 0.024 | 0.213 | hein_WMM bioplex (APTX) bioplex_WMM |
| BCL2L1 | BCL2L15 | 0.024 | 0.213 | bioplex (BCL2L15) bioplex_WMM |
| BAD | BCL2 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| BCL2 | RHPN2 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| BCL2L1 | RHPN2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| BAD | BCL2L11 | 0.008 | 0.068 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01477 has an average edge precision of 0.392 which is ranked 3406 out of all 6965 complexes.
Related Complexes