hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01488
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SPTAN1 | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | UniProt NCBI |
| SPTBN2 | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | UniProt NCBI |
| SPTBN1 | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-445095 | 1.64282711281e-06 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Interaction between L1 and Ankyrins |
| GO:0008091 | 5.08584025729e-06 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | spectrin |
| REAC:R-HSA-375165 | 8.81209945571e-06 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-6807878 | 6.62885685587e-05 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | COPI-mediated anterograde transport |
| REAC:R-HSA-373760 | 9.97273388147e-05 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | L1CAM interactions |
| REAC:R-HSA-199977 | 0.000219108356997 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.000355291261341 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-5673001 | 0.00053868184134 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.000581643074171 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.000693937096245 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | FLT3 Signaling |
| REAC:R-HSA-449836 | 0.000864945777315 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.00097245114269 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | MAPK family signaling cascades |
| REAC:R-HSA-373753 | 0.00154525199441 | 0.666666666667 | SPTBN1 SPTAN1 | Nephrin family interactions |
| REAC:R-HSA-446203 | 0.00171641263924 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Asparagine N-linked glycosylation |
| GO:0030864 | 0.00475834847216 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | cortical actin cytoskeleton |
| GO:0030863 | 0.00865355719779 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | cortical cytoskeleton |
| REAC:R-HSA-449147 | 0.00988151966016 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Signaling by Interleukins |
| REAC:R-HSA-422475 | 0.0100572742862 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Axon guidance |
| GO:0005200 | 0.0106693663112 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | structural constituent of cytoskeleton |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Vesicle-mediated transport |
| REAC:R-HSA-1280215 | 0.0245091821355 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | Cytokine Signaling in Immune system |
| REAC:R-HSA-1500931 | 0.0350118981581 | 0.666666666667 | SPTBN1 SPTAN1 | Cell-Cell communication |
| GO:0044448 | 0.0380729634404 | 1.0 | SPTBN2 SPTAN1 SPTBN1 | cell cortex part |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SPTAN1 | SPTBN1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| SPTAN1 | SPTBN2 | 1.0 | 0.949 | hein_WMM bioplex_WMM fraction boldt_WMM treiber_WMM |
| SPTBN2 | SPTBN1 | 0.005 | 0.013 | hein_WMM bioplex_WMM WMM_only boldt_WMM treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_01488 has an average edge precision of 0.637 which is ranked 1734 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SPTAN1 | HuMAP2_00229 HuMAP2_01215 HuMAP2_01488 HuMAP2_01543 HuMAP2_04549 |
| SPTBN2 | HuMAP2_00229 HuMAP2_01488 HuMAP2_05066 |
| SPTBN1 | HuMAP2_00229 HuMAP2_01215 HuMAP2_01488 |