hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01492
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDIA6 | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | UniProt NCBI |
| HSP90B1 | Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog) | UniProt NCBI |
| HYOU1 | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) | UniProt NCBI |
| HSPA5 | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-381119 | 1.66653425471e-07 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | Unfolded Protein Response (UPR) |
| KEGG:04141 | 4.40192334434e-07 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | Protein processing in endoplasmic reticulum |
| WP:WP3613 | 5.8597456504e-07 | 0.75 | HSP90B1 HSPA5 PDIA6 | Photodynamic therapy-induced unfolded protein response |
| GO:0034663 | 3.6323771075e-06 | 0.75 | HYOU1 HSPA5 PDIA6 | endoplasmic reticulum chaperone complex |
| REAC:R-HSA-381070 | 2.0455616978e-05 | 0.75 | HYOU1 HSPA5 PDIA6 | IRE1alpha activates chaperones |
| GO:0030968 | 0.000103670767632 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | endoplasmic reticulum unfolded protein response |
| GO:0034620 | 0.000200399046415 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | cellular response to unfolded protein |
| REAC:R-HSA-381183 | 0.000361772624521 | 0.5 | HSP90B1 HSPA5 | ATF6 (ATF6-alpha) activates chaperone genes |
| GO:0006986 | 0.000363289575714 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | response to unfolded protein |
| GO:0035967 | 0.000363289575714 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | cellular response to topologically incorrect protein |
| CORUM:6859 | 0.000391779955301 | 0.5 | HSP90B1 HSPA5 | HRD1 complex |
| REAC:R-HSA-381033 | 0.000552609179875 | 0.5 | HSP90B1 HSPA5 | ATF6 (ATF6-alpha) activates chaperones |
| WP:WP3995 | 0.000633595541779 | 0.5 | HSP90B1 HSPA5 | Prion disease pathway |
| GO:0035966 | 0.000657808747052 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | response to topologically incorrect protein |
| GO:0005788 | 0.00334428065319 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | endoplasmic reticulum lumen |
| GO:0034976 | 0.00340048705072 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | response to endoplasmic reticulum stress |
| KEGG:04918 | 0.00453740909542 | 0.5 | HSP90B1 HSPA5 | Thyroid hormone synthesis |
| REAC:R-HSA-2173782 | 0.00596538345738 | 0.5 | HSP90B1 HYOU1 | Binding and Uptake of Ligands by Scavenger Receptors |
| REAC:R-HSA-381038 | 0.00947680746611 | 0.5 | HYOU1 PDIA6 | XBP1(S) activates chaperone genes |
| GO:0036498 | 0.0130360493673 | 0.75 | HYOU1 HSPA5 PDIA6 | IRE1-mediated unfolded protein response |
| MIRNA:hsa-miR-16-5p | 0.0327487117901 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | hsa-miR-16-5p |
| REAC:R-HSA-8957275 | 0.0390714342086 | 0.5 | HSP90B1 PDIA6 | Post-translational protein phosphorylation |
| REAC:R-HSA-392499 | 0.0403329683602 | 1.0 | HSP90B1 HSPA5 PDIA6 HYOU1 | Metabolism of proteins |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSPA5 | HSP90B1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt (HSPA5) hein (HSPA5) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| HSPA5 | HYOU1 | 0.995 | 0.923 | hein_WMM bioplex_WMM boldt (HSPA5) hein (HSPA5) gupta_WMM fraction boldt_WMM treiber_WMM |
| PDIA6 | HYOU1 | 0.971 | 0.883 | bioplex (PDIA6) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| HSPA5 | PDIA6 | 0.904 | 0.828 | bioplex (PDIA6) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| HSP90B1 | HYOU1 | 0.035 | 0.26 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| HSP90B1 | PDIA6 | 0.0 | 0.013 | bioplex (PDIA6) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_01492 has an average edge precision of 0.643 which is ranked 1701 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDIA6 | HuMAP2_01369 HuMAP2_01492 HuMAP2_03134 |
| HSP90B1 | HuMAP2_00960 HuMAP2_01492 HuMAP2_01924 HuMAP2_03097 HuMAP2_03795 |
| HYOU1 | HuMAP2_01492 HuMAP2_03134 |
| HSPA5 | HuMAP2_00386 HuMAP2_01492 HuMAP2_03795 |