hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01496
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK1 | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | UniProt NCBI |
| MAPK3 | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2868 | 3.72581331718e-06 | 1.0 | MAPK1 MAPK3 | TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer |
| CORUM:6937 | 1.00555407742e-05 | 1.0 | MAPK1 MAPK3 | ARHGEF2-MAPK1-MAPK3-PXN complex |
| CORUM:7504 | 1.00555407742e-05 | 1.0 | MAPK1 MAPK3 | CD44-ERK1-ERK2-RHAMM complex |
| CORUM:6801 | 1.67592346237e-05 | 1.0 | MAPK1 MAPK3 | VEGFR2-S1PR3-ERK1/2-PKC-alpha complex |
| CORUM:6800 | 1.67592346237e-05 | 1.0 | MAPK1 MAPK3 | VEGFR2-S1PR2-ERK1/2-PKC-alpha complex |
| CORUM:6799 | 1.67592346237e-05 | 1.0 | MAPK1 MAPK3 | VEGFR2-S1PR1-ERK1/2-PKC-alpha complex |
| CORUM:6802 | 1.67592346237e-05 | 1.0 | MAPK1 MAPK3 | VEGFR2-S1PR5-ERK1/2-PKC-alpha complex |
| WP:WP4389 | 1.67661599273e-05 | 1.0 | MAPK1 MAPK3 | Bile Acids synthesis and enterohepatic circulation |
| WP:WP3301 | 2.45903678934e-05 | 1.0 | MAPK1 MAPK3 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| REAC:R-HSA-5674499 | 2.51388519356e-05 | 1.0 | MAPK1 MAPK3 | Negative feedback regulation of MAPK pathway |
| WP:WP1434 | 2.9061343874e-05 | 1.0 | MAPK1 MAPK3 | Osteopontin Signaling |
| REAC:R-HSA-444257 | 3.51943927099e-05 | 1.0 | MAPK1 MAPK3 | RSK activation |
| WP:WP3859 | 3.91210398304e-05 | 1.0 | MAPK1 MAPK3 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| WP:WP22 | 4.47097598062e-05 | 1.0 | MAPK1 MAPK3 | IL-9 Signaling Pathway |
| WP:WP734 | 4.47097598062e-05 | 1.0 | MAPK1 MAPK3 | Serotonin Receptor 4/6/7 and NR3C Signaling |
| REAC:R-HSA-170968 | 4.69258569465e-05 | 1.0 | MAPK1 MAPK3 | Frs2-mediated activation |
| REAC:R-HSA-74749 | 4.69258569465e-05 | 1.0 | MAPK1 MAPK3 | Signal attenuation |
| WP:WP4560 | 5.06710611136e-05 | 1.0 | MAPK1 MAPK3 | MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement |
| WP:WP3879 | 5.70049437529e-05 | 1.0 | MAPK1 MAPK3 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| WP:WP4301 | 5.70049437529e-05 | 1.0 | MAPK1 MAPK3 | Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells |
| KEGG:05020 | 5.9234402919e-05 | 1.0 | MAPK1 MAPK3 | Prion diseases |
| KEGG:04960 | 6.7842358023e-05 | 1.0 | MAPK1 MAPK3 | Aldosterone-regulated sodium reabsorption |
| WP:WP4331 | 7.07904530264e-05 | 1.0 | MAPK1 MAPK3 | Neovascularisation processes |
| WP:WP732 | 7.07904530264e-05 | 1.0 | MAPK1 MAPK3 | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling |
| REAC:R-HSA-450341 | 7.54165558069e-05 | 1.0 | MAPK1 MAPK3 | Activation of the AP-1 family of transcription factors |
| WP:WP205 | 8.60662876269e-05 | 1.0 | MAPK1 MAPK3 | IL-7 Signaling Pathway |
| REAC:R-HSA-879415 | 9.21757904306e-05 | 1.0 | MAPK1 MAPK3 | Advanced glycosylation endproduct receptor signaling |
| REAC:R-HSA-169893 | 9.21757904306e-05 | 1.0 | MAPK1 MAPK3 | Prolonged ERK activation events |
| WP:WP3869 | 9.42630769247e-05 | 1.0 | MAPK1 MAPK3 | Cannabinoid receptor signaling |
| KEGG:05219 | 9.71677643943e-05 | 1.0 | MAPK1 MAPK3 | Bladder cancer |
| KEGG:05216 | 9.71677643943e-05 | 1.0 | MAPK1 MAPK3 | Thyroid cancer |
| WP:WP2035 | 0.000102832447554 | 1.0 | MAPK1 MAPK3 | Follicle Stimulating Hormone (FSH) signaling pathway |
| REAC:R-HSA-111458 | 0.000110610948517 | 1.0 | MAPK1 MAPK3 | Formation of apoptosome |
| REAC:R-HSA-9627069 | 0.000110610948517 | 1.0 | MAPK1 MAPK3 | Regulation of the apoptosome activity |
| WP:WP26 | 0.000111774399515 | 1.0 | MAPK1 MAPK3 | Signal Transduction of S1P Receptor |
| WP:WP3668 | 0.000111774399515 | 1.0 | MAPK1 MAPK3 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| WP:WP581 | 0.000121088932808 | 1.0 | MAPK1 MAPK3 | EPO Receptor Signaling |
| REAC:R-HSA-202670 | 0.000130722030065 | 1.0 | MAPK1 MAPK3 | ERKs are inactivated |
| KEGG:04930 | 0.000138019076752 | 1.0 | MAPK1 MAPK3 | Type II diabetes mellitus |
| WP:WP2112 | 0.000140835743389 | 1.0 | MAPK1 MAPK3 | IL17 signaling pathway |
| WP:WP3995 | 0.000140835743389 | 1.0 | MAPK1 MAPK3 | Prion disease pathway |
| REAC:R-HSA-1295596 | 0.000152509035076 | 1.0 | MAPK1 MAPK3 | Spry regulation of FGF signaling |
| REAC:R-HSA-111461 | 0.000152509035076 | 1.0 | MAPK1 MAPK3 | Cytochrome c-mediated apoptotic response |
| WP:WP4481 | 0.000162072879297 | 1.0 | MAPK1 MAPK3 | Resistin as a regulator of inflammation |
| WP:WP244 | 0.000196722943147 | 1.0 | MAPK1 MAPK3 | Alpha 6 Beta 4 signaling pathway |
| WP:WP422 | 0.000196722943147 | 1.0 | MAPK1 MAPK3 | MAPK Cascade |
| KEGG:04730 | 0.000201046815819 | 1.0 | MAPK1 MAPK3 | Long-term depression |
| REAC:R-HSA-881907 | 0.000201110815485 | 1.0 | MAPK1 MAPK3 | Gastrin-CREB signalling pathway via PKC and MAPK |
| REAC:R-HSA-111471 | 0.000201110815485 | 1.0 | MAPK1 MAPK3 | Apoptotic factor-mediated response |
| KEGG:04929 | 0.000208779385658 | 1.0 | MAPK1 MAPK3 | GnRH secretion |
| WP:WP313 | 0.000209018127094 | 1.0 | MAPK1 MAPK3 | Signaling of Hepatocyte Growth Factor Receptor |
| WP:WP4553 | 0.000209018127094 | 1.0 | MAPK1 MAPK3 | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| KEGG:04664 | 0.000216657853041 | 1.0 | MAPK1 MAPK3 | Fc epsilon RI signaling pathway |
| KEGG:04370 | 0.000216657853041 | 1.0 | MAPK1 MAPK3 | VEGF signaling pathway |
| KEGG:05140 | 0.00023285248044 | 1.0 | MAPK1 MAPK3 | Leishmaniasis |
| KEGG:05213 | 0.00023285248044 | 1.0 | MAPK1 MAPK3 | Endometrial cancer |
| KEGG:05133 | 0.00025823865312 | 1.0 | MAPK1 MAPK3 | Pertussis |
| KEGG:05221 | 0.00025823865312 | 1.0 | MAPK1 MAPK3 | Acute myeloid leukemia |
| WP:WP2636 | 0.000261924676198 | 1.0 | MAPK1 MAPK3 | Common Pathways Underlying Drug Addiction |
| WP:WP127 | 0.000261924676198 | 1.0 | MAPK1 MAPK3 | IL-5 Signaling Pathway |
| KEGG:04720 | 0.00027589225596 | 1.0 | MAPK1 MAPK3 | Long-term potentiation |
| KEGG:05218 | 0.00027589225596 | 1.0 | MAPK1 MAPK3 | Melanoma |
| KEGG:04917 | 0.00027589225596 | 1.0 | MAPK1 MAPK3 | Prolactin signaling pathway |
| WP:WP2332 | 0.000276082766803 | 1.0 | MAPK1 MAPK3 | Interleukin-11 Signaling Pathway |
| KEGG:05211 | 0.000284937903697 | 1.0 | MAPK1 MAPK3 | Renal cell carcinoma |
| REAC:R-HSA-5654732 | 0.000286582912066 | 1.0 | MAPK1 MAPK3 | Negative regulation of FGFR3 signaling |
| REAC:R-HSA-112409 | 0.000286582912066 | 1.0 | MAPK1 MAPK3 | RAF-independent MAPK1/3 activation |
| REAC:R-HSA-5668599 | 0.000286582912066 | 1.0 | MAPK1 MAPK3 | RHO GTPases Activate NADPH Oxidases |
| REAC:R-HSA-8940973 | 0.000286582912066 | 1.0 | MAPK1 MAPK3 | RUNX2 regulates osteoblast differentiation |
| REAC:R-HSA-9634638 | 0.000286582912066 | 1.0 | MAPK1 MAPK3 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
| WP:WP49 | 0.00029061343874 | 1.0 | MAPK1 MAPK3 | IL-2 Signaling Pathway |
| WP:WP2036 | 0.00029061343874 | 1.0 | MAPK1 MAPK3 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| WP:WP2526 | 0.00029061343874 | 1.0 | MAPK1 MAPK3 | PDGF Pathway |
| KEGG:05131 | 0.000294129448977 | 1.0 | MAPK1 MAPK3 | Shigellosis |
| KEGG:05223 | 0.000294129448977 | 1.0 | MAPK1 MAPK3 | Non-small cell lung cancer |
| WP:WP2203 | 0.000305516692009 | 1.0 | MAPK1 MAPK3 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| REAC:R-HSA-982772 | 0.000318425457851 | 1.0 | MAPK1 MAPK3 | Growth hormone receptor signaling |
| REAC:R-HSA-445144 | 0.000318425457851 | 1.0 | MAPK1 MAPK3 | Signal transduction by L1 |
| WP:WP364 | 0.000320792526609 | 1.0 | MAPK1 MAPK3 | IL-6 signaling pathway |
| WP:WP286 | 0.000320792526609 | 1.0 | MAPK1 MAPK3 | IL-3 Signaling Pathway |
| KEGG:05132 | 0.000322579470084 | 1.0 | MAPK1 MAPK3 | Salmonella infection |
| KEGG:05230 | 0.000322579470084 | 1.0 | MAPK1 MAPK3 | Central carbon metabolism in cancer |
| KEGG:04662 | 0.000322579470084 | 1.0 | MAPK1 MAPK3 | B cell receptor signaling pathway |
| KEGG:05214 | 0.000332354605541 | 1.0 | MAPK1 MAPK3 | Glioma |
| KEGG:04520 | 0.000342275638542 | 1.0 | MAPK1 MAPK3 | Adherens junction |
| KEGG:04657 | 0.000352342569087 | 1.0 | MAPK1 MAPK3 | IL-17 signaling pathway |
| WP:WP4535 | 0.000352461939805 | 1.0 | MAPK1 MAPK3 | Envelope proteins and their potential roles in EDMD physiopathology |
| KEGG:04658 | 0.000362555397177 | 1.0 | MAPK1 MAPK3 | Th1 and Th2 cell differentiation |
| KEGG:05212 | 0.000362555397177 | 1.0 | MAPK1 MAPK3 | Pancreatic cancer |
| KEGG:01524 | 0.00037291412281 | 1.0 | MAPK1 MAPK3 | Platinum drug resistance |
| WP:WP4566 | 0.000385621678328 | 1.0 | MAPK1 MAPK3 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-5654733 | 0.000387138319809 | 1.0 | MAPK1 MAPK3 | Negative regulation of FGFR4 signaling |
| REAC:R-HSA-5654726 | 0.000387138319809 | 1.0 | MAPK1 MAPK3 | Negative regulation of FGFR1 signaling |
| REAC:R-HSA-198753 | 0.000387138319809 | 1.0 | MAPK1 MAPK3 | ERK/MAPK targets |
| KEGG:05220 | 0.00039406926671 | 1.0 | MAPK1 MAPK3 | Chronic myeloid leukemia |
| KEGG:01521 | 0.00039406926671 | 1.0 | MAPK1 MAPK3 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP4539 | 0.000402760419587 | 1.0 | MAPK1 MAPK3 | Synaptic signaling pathways associated with autism spectrum disorder |
| WP:WP2795 | 0.000420271742178 | 1.0 | MAPK1 MAPK3 | Cardiac Hypertrophic Response |
| REAC:R-HSA-5654727 | 0.000424008635981 | 1.0 | MAPK1 MAPK3 | Negative regulation of FGFR2 signaling |
| KEGG:04350 | 0.000438130325039 | 1.0 | MAPK1 MAPK3 | TGF-beta signaling pathway |
| WP:WP2637 | 0.0004381556461 | 1.0 | MAPK1 MAPK3 | Structural Pathway of Interleukin 1 (IL-1) |
| KEGG:04012 | 0.000449510333482 | 1.0 | MAPK1 MAPK3 | ErbB signaling pathway |
| KEGG:05235 | 0.000461036239468 | 1.0 | MAPK1 MAPK3 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| REAC:R-HSA-8941326 | 0.000462554875615 | 1.0 | MAPK1 MAPK3 | RUNX2 regulates bone development |
| KEGG:04912 | 0.000472708042999 | 1.0 | MAPK1 MAPK3 | GnRH signaling pathway |
| KEGG:04914 | 0.000472708042999 | 1.0 | MAPK1 MAPK3 | Progesterone-mediated oocyte maturation |
| WP:WP195 | 0.00047504119794 | 1.0 | MAPK1 MAPK3 | IL-1 signaling pathway |
| KEGG:05210 | 0.000484525744074 | 1.0 | MAPK1 MAPK3 | Colorectal cancer |
| WP:WP395 | 0.000494042845858 | 1.0 | MAPK1 MAPK3 | IL-4 Signaling Pathway |
| WP:WP2018 | 0.000494042845858 | 1.0 | MAPK1 MAPK3 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| REAC:R-HSA-198725 | 0.000502777038712 | 1.0 | MAPK1 MAPK3 | Nuclear Events (kinase and transcription factor activation) |
| KEGG:04540 | 0.000508598838856 | 1.0 | MAPK1 MAPK3 | Gap junction |
| KEGG:04659 | 0.000533255523815 | 1.0 | MAPK1 MAPK3 | Th17 cell differentiation |
| KEGG:04620 | 0.000533255523815 | 1.0 | MAPK1 MAPK3 | Toll-like receptor signaling pathway |
| REAC:R-HSA-442742 | 0.000544675125272 | 1.0 | MAPK1 MAPK3 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-2871796 | 0.000544675125272 | 1.0 | MAPK1 MAPK3 | FCERI mediated MAPK activation |
| KEGG:04625 | 0.000558495798951 | 1.0 | MAPK1 MAPK3 | C-type lectin receptor signaling pathway |
| KEGG:05142 | 0.000558495798951 | 1.0 | MAPK1 MAPK3 | Chagas disease (American trypanosomiasis) |
| KEGG:04713 | 0.000558495798951 | 1.0 | MAPK1 MAPK3 | Circadian entrainment |
| KEGG:04666 | 0.000558495798951 | 1.0 | MAPK1 MAPK3 | Fc gamma R-mediated phagocytosis |
| KEGG:04916 | 0.000571334782835 | 1.0 | MAPK1 MAPK3 | Melanogenesis |
| KEGG:05231 | 0.000571334782835 | 1.0 | MAPK1 MAPK3 | Choline metabolism in cancer |
| WP:WP304 | 0.000573775250846 | 1.0 | MAPK1 MAPK3 | Kit receptor signaling pathway |
| WP:WP4538 | 0.000573775250846 | 1.0 | MAPK1 MAPK3 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:04660 | 0.000584319664263 | 1.0 | MAPK1 MAPK3 | T cell receptor signaling pathway |
| KEGG:05215 | 0.000584319664263 | 1.0 | MAPK1 MAPK3 | Prostate cancer |
| KEGG:01522 | 0.000584319664263 | 1.0 | MAPK1 MAPK3 | Endocrine resistance |
| WP:WP4205 | 0.000594639805422 | 1.0 | MAPK1 MAPK3 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04933 | 0.000597450443235 | 1.0 | MAPK1 MAPK3 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04668 | 0.000624149693812 | 1.0 | MAPK1 MAPK3 | TNF signaling pathway |
| REAC:R-HSA-456926 | 0.000633499068778 | 1.0 | MAPK1 MAPK3 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-5654741 | 0.000633499068778 | 1.0 | MAPK1 MAPK3 | Signaling by FGFR3 |
| KEGG:05145 | 0.000637718165416 | 1.0 | MAPK1 MAPK3 | Toxoplasmosis |
| KEGG:04726 | 0.000651432534565 | 1.0 | MAPK1 MAPK3 | Serotonergic synapse |
| KEGG:04725 | 0.000665292801258 | 1.0 | MAPK1 MAPK3 | Cholinergic synapse |
| KEGG:04928 | 0.000679298965495 | 1.0 | MAPK1 MAPK3 | Parathyroid hormone synthesis, secretion and action |
| REAC:R-HSA-187687 | 0.000680424925724 | 1.0 | MAPK1 MAPK3 | Signalling to ERKs |
| WP:WP4155 | 0.000704551298279 | 1.0 | MAPK1 MAPK3 | Endometrial cancer |
| KEGG:04270 | 0.000707748986601 | 1.0 | MAPK1 MAPK3 | Vascular smooth muscle contraction |
| KEGG:04650 | 0.000707748986601 | 1.0 | MAPK1 MAPK3 | Natural killer cell mediated cytotoxicity |
| KEGG:04066 | 0.000722192843471 | 1.0 | MAPK1 MAPK3 | HIF-1 signaling pathway |
| KEGG:04724 | 0.000722192843471 | 1.0 | MAPK1 MAPK3 | Glutamatergic synapse |
| WP:WP4341 | 0.000727651340845 | 1.0 | MAPK1 MAPK3 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| REAC:R-HSA-5654743 | 0.000729026706133 | 1.0 | MAPK1 MAPK3 | Signaling by FGFR4 |
| WP:WP2374 | 0.000751123964743 | 1.0 | MAPK1 MAPK3 | Oncostatin M Signaling Pathway |
| KEGG:04380 | 0.000766399799344 | 1.0 | MAPK1 MAPK3 | Osteoclast differentiation |
| WP:WP2032 | 0.000774969169973 | 1.0 | MAPK1 MAPK3 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| WP:WP3303 | 0.000774969169973 | 1.0 | MAPK1 MAPK3 | RAC1/PAK1/p38/MMP2 Pathway |
| WP:WP2324 | 0.000774969169973 | 1.0 | MAPK1 MAPK3 | AGE/RAGE pathway |
| REAC:R-HSA-450282 | 0.000779304410004 | 1.0 | MAPK1 MAPK3 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04722 | 0.000827384972793 | 1.0 | MAPK1 MAPK3 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.000827384972793 | 1.0 | MAPK1 MAPK3 | Oocyte meiosis |
| REAC:R-HSA-2559585 | 0.000831258037338 | 1.0 | MAPK1 MAPK3 | Oncogene Induced Senescence |
| KEGG:04071 | 0.000858752944782 | 1.0 | MAPK1 MAPK3 | Sphingolipid signaling pathway |
| KEGG:04611 | 0.000890704506947 | 1.0 | MAPK1 MAPK3 | Platelet activation |
| WP:WP4255 | 0.000899783916099 | 1.0 | MAPK1 MAPK3 | Non-small cell lung cancer |
| KEGG:05135 | 0.000906899134346 | 1.0 | MAPK1 MAPK3 | Yersinia infection |
| KEGG:04919 | 0.00092323965929 | 1.0 | MAPK1 MAPK3 | Thyroid hormone signaling pathway |
| WP:WP4216 | 0.000925864609319 | 1.0 | MAPK1 MAPK3 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:04068 | 0.000939726081777 | 1.0 | MAPK1 MAPK3 | FoxO signaling pathway |
| REAC:R-HSA-5663213 | 0.000997174460113 | 1.0 | MAPK1 MAPK3 | RHO GTPases Activate WASPs and WAVEs |
| WP:WP2037 | 0.00100634217697 | 1.0 | MAPK1 MAPK3 | Prolactin Signaling Pathway |
| WP:WP2034 | 0.00100634217697 | 1.0 | MAPK1 MAPK3 | Leptin signaling pathway |
| WP:WP4298 | 0.00103391319552 | 1.0 | MAPK1 MAPK3 | Viral Acute Myocarditis |
| KEGG:04926 | 0.00104170846513 | 1.0 | MAPK1 MAPK3 | Relaxin signaling pathway |
| REAC:R-HSA-74751 | 0.0010558317813 | 1.0 | MAPK1 MAPK3 | Insulin receptor signalling cascade |
| REAC:R-HSA-6802948 | 0.0010558317813 | 1.0 | MAPK1 MAPK3 | Signaling by high-kinase activity BRAF mutants |
| REAC:R-HSA-5654736 | 0.0010558317813 | 1.0 | MAPK1 MAPK3 | Signaling by FGFR1 |
| WP:WP1544 | 0.0010618567954 | 1.0 | MAPK1 MAPK3 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04915 | 0.00107686977326 | 1.0 | MAPK1 MAPK3 | Estrogen signaling pathway |
| WP:WP69 | 0.00109017297661 | 1.0 | MAPK1 MAPK3 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:04550 | 0.00109466927365 | 1.0 | MAPK1 MAPK3 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04371 | 0.00111261467158 | 1.0 | MAPK1 MAPK3 | Apelin signaling pathway |
| REAC:R-HSA-5675221 | 0.00111616502594 | 1.0 | MAPK1 MAPK3 | Negative regulation of MAPK pathway |
| KEGG:04910 | 0.00113070596705 | 1.0 | MAPK1 MAPK3 | Insulin signaling pathway |
| KEGG:04210 | 0.00113070596705 | 1.0 | MAPK1 MAPK3 | Apoptosis |
| KEGG:04072 | 0.00114894316007 | 1.0 | MAPK1 MAPK3 | Phospholipase D signaling pathway |
| WP:WP2059 | 0.00117735700823 | 1.0 | MAPK1 MAPK3 | Alzheimers Disease |
| KEGG:04261 | 0.00120453012438 | 1.0 | MAPK1 MAPK3 | Adrenergic signaling in cardiomyocytes |
| KEGG:05224 | 0.00122335090758 | 1.0 | MAPK1 MAPK3 | Breast cancer |
| KEGG:04062 | 0.00122335090758 | 1.0 | MAPK1 MAPK3 | Chemokine signaling pathway |
| WP:WP2261 | 0.00123734260264 | 1.0 | MAPK1 MAPK3 | Signaling Pathways in Glioblastoma |
| KEGG:05226 | 0.00124231758831 | 1.0 | MAPK1 MAPK3 | Gastric cancer |
| KEGG:04723 | 0.0012614301666 | 1.0 | MAPK1 MAPK3 | Retrograde endocannabinoid signaling |
| WP:WP4263 | 0.00126789427184 | 1.0 | MAPK1 MAPK3 | Pancreatic adenocarcinoma pathway |
| KEGG:04140 | 0.00128068864242 | 1.0 | MAPK1 MAPK3 | Autophagy - animal |
| WP:WP2355 | 0.00129881852237 | 1.0 | MAPK1 MAPK3 | Corticotropin-releasing hormone signaling pathway |
| REAC:R-HSA-5674135 | 0.00130722030065 | 1.0 | MAPK1 MAPK3 | MAP2K and MAPK activation |
| KEGG:04921 | 0.00131964328671 | 1.0 | MAPK1 MAPK3 | Oxytocin signaling pathway |
| WP:WP673 | 0.00133011535423 | 1.0 | MAPK1 MAPK3 | ErbB Signaling Pathway |
| KEGG:05160 | 0.00133933945516 | 1.0 | MAPK1 MAPK3 | Hepatitis C |
| WP:WP75 | 0.00142624133782 | 1.0 | MAPK1 MAPK3 | Toll-like Receptor Signaling Pathway |
| WP:WP231 | 0.00142624133782 | 1.0 | MAPK1 MAPK3 | TNF alpha Signaling Pathway |
| KEGG:04934 | 0.00144000876062 | 1.0 | MAPK1 MAPK3 | Cushing syndrome |
| KEGG:04022 | 0.00144000876062 | 1.0 | MAPK1 MAPK3 | cGMP-PKG signaling pathway |
| WP:WP2431 | 0.00145902849501 | 1.0 | MAPK1 MAPK3 | Spinal Cord Injury |
| KEGG:04150 | 0.00150216111442 | 1.0 | MAPK1 MAPK3 | mTOR signaling pathway |
| KEGG:04218 | 0.00152317036077 | 1.0 | MAPK1 MAPK3 | Cellular senescence |
| REAC:R-HSA-6802946 | 0.00158542359541 | 1.0 | MAPK1 MAPK3 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-6802955 | 0.00158542359541 | 1.0 | MAPK1 MAPK3 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| KEGG:05164 | 0.00158707348511 | 1.0 | MAPK1 MAPK3 | Influenza A |
| KEGG:05152 | 0.00163040505571 | 1.0 | MAPK1 MAPK3 | Tuberculosis |
| KEGG:05010 | 0.00171881896746 | 1.0 | MAPK1 MAPK3 | Alzheimer disease |
| KEGG:05161 | 0.00174128718926 | 1.0 | MAPK1 MAPK3 | Hepatitis B |
| KEGG:05206 | 0.00178666132548 | 1.0 | MAPK1 MAPK3 | MicroRNAs in cancer |
| KEGG:04621 | 0.00180956723991 | 1.0 | MAPK1 MAPK3 | NOD-like receptor signaling pathway |
| KEGG:05225 | 0.00183261905189 | 1.0 | MAPK1 MAPK3 | Hepatocellular carcinoma |
| KEGG:04360 | 0.00197399377215 | 1.0 | MAPK1 MAPK3 | Axon guidance |
| KEGG:05167 | 0.00197399377215 | 1.0 | MAPK1 MAPK3 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05034 | 0.00199806686694 | 1.0 | MAPK1 MAPK3 | Alcoholism |
| REAC:R-HSA-375165 | 0.00205300624141 | 1.0 | MAPK1 MAPK3 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-109606 | 0.00205300624141 | 1.0 | MAPK1 MAPK3 | Intrinsic Pathway for Apoptosis |
| KEGG:04024 | 0.00209581822151 | 1.0 | MAPK1 MAPK3 | cAMP signaling pathway |
| MIRNA:hsa-miR-550a-3p | 0.00211832687274 | 1.0 | MAPK1 MAPK3 | hsa-miR-550a-3p |
| KEGG:04015 | 0.00217066366165 | 1.0 | MAPK1 MAPK3 | Rap1 signaling pathway |
| KEGG:05130 | 0.00227250014745 | 1.0 | MAPK1 MAPK3 | Pathogenic Escherichia coli infection |
| KEGG:04014 | 0.00245633105307 | 1.0 | MAPK1 MAPK3 | Ras signaling pathway |
| KEGG:04810 | 0.00253730419006 | 1.0 | MAPK1 MAPK3 | Regulation of actin cytoskeleton |
| KEGG:05203 | 0.00256458703081 | 1.0 | MAPK1 MAPK3 | Viral carcinogenesis |
| KEGG:05205 | 0.00256458703081 | 1.0 | MAPK1 MAPK3 | Proteoglycans in cancer |
| WP:WP4217 | 0.00257192893285 | 1.0 | MAPK1 MAPK3 | Ebola Virus Pathway on Host |
| WP:WP1449 | 0.00257192893285 | 1.0 | MAPK1 MAPK3 | Regulation of toll-like receptor signaling pathway |
| REAC:R-HSA-6802949 | 0.00258092213206 | 1.0 | MAPK1 MAPK3 | Signaling by RAS mutants |
| KEGG:04510 | 0.00259201576911 | 1.0 | MAPK1 MAPK3 | Focal adhesion |
| REAC:R-HSA-8943724 | 0.00267477384595 | 1.0 | MAPK1 MAPK3 | Regulation of PTEN gene transcription |
| GO:0090170 | 0.00270494046827 | 1.0 | MAPK1 MAPK3 | regulation of Golgi inheritance |
| REAC:R-HSA-5654738 | 0.00277030148331 | 1.0 | MAPK1 MAPK3 | Signaling by FGFR2 |
| KEGG:05166 | 0.00281669798708 | 1.0 | MAPK1 MAPK3 | Human T-cell leukemia virus 1 infection |
| WP:WP3915 | 0.00284130523568 | 1.0 | MAPK1 MAPK3 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP3929 | 0.00284130523568 | 1.0 | MAPK1 MAPK3 | Chemokine signaling pathway |
| REAC:R-HSA-2029482 | 0.00286750504412 | 1.0 | MAPK1 MAPK3 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-74752 | 0.00286750504412 | 1.0 | MAPK1 MAPK3 | Signaling by Insulin receptor |
| KEGG:05170 | 0.00287432751701 | 1.0 | MAPK1 MAPK3 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0029618660435 | 1.0 | MAPK1 MAPK3 | Human cytomegalovirus infection |
| WP:WP51 | 0.00322133819403 | 1.0 | MAPK1 MAPK3 | Regulation of Actin Cytoskeleton |
| REAC:R-HSA-450294 | 0.00327307852202 | 1.0 | MAPK1 MAPK3 | MAP kinase activation |
| REAC:R-HSA-6802952 | 0.00327307852202 | 1.0 | MAPK1 MAPK3 | Signaling by BRAF and RAF fusions |
| WP:WP4239 | 0.00336999814539 | 1.0 | MAPK1 MAPK3 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP2380 | 0.00342029662517 | 1.0 | MAPK1 MAPK3 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-3371453 | 0.00348592080174 | 1.0 | MAPK1 MAPK3 | Regulation of HSF1-mediated heat shock response |
| WP:WP4262 | 0.00357342755251 | 1.0 | MAPK1 MAPK3 | Breast cancer pathway |
| REAC:R-HSA-9009391 | 0.00359485582679 | 1.0 | MAPK1 MAPK3 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-190236 | 0.00370546677531 | 1.0 | MAPK1 MAPK3 | Signaling by FGFR |
| WP:WP4666 | 0.00388974910314 | 1.0 | MAPK1 MAPK3 | Hepatitis B infection |
| REAC:R-HSA-6811558 | 0.00393171644273 | 1.0 | MAPK1 MAPK3 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-448424 | 0.00393171644273 | 1.0 | MAPK1 MAPK3 | Interleukin-17 signaling |
| WP:WP481 | 0.00438938066897 | 1.0 | MAPK1 MAPK3 | Insulin Signaling |
| REAC:R-HSA-438064 | 0.00440432685912 | 1.0 | MAPK1 MAPK3 | Post NMDA receptor activation events |
| REAC:R-HSA-187037 | 0.00440432685912 | 1.0 | MAPK1 MAPK3 | Signaling by NTRK1 (TRKA) |
| WP:WP4223 | 0.00444675819405 | 1.0 | MAPK1 MAPK3 | Ras Signaling |
| KEGG:04010 | 0.00476209584058 | 1.0 | MAPK1 MAPK3 | MAPK signaling pathway |
| REAC:R-HSA-199418 | 0.00477638186777 | 1.0 | MAPK1 MAPK3 | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-6802957 | 0.00503279815751 | 1.0 | MAPK1 MAPK3 | Oncogenic MAPK signaling |
| REAC:R-HSA-2029480 | 0.0052959181411 | 1.0 | MAPK1 MAPK3 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-168176 | 0.00556574181855 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.00556574181855 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.00556574181855 | 1.0 | MAPK1 MAPK3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 0.00584226918984 | 1.0 | MAPK1 MAPK3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-442755 | 0.00584226918984 | 1.0 | MAPK1 MAPK3 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-168181 | 0.00598304676068 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-3371556 | 0.00598304676068 | 1.0 | MAPK1 MAPK3 | Cellular response to heat stress |
| REAC:R-HSA-975155 | 0.00598304676068 | 1.0 | MAPK1 MAPK3 | MyD88 dependent cascade initiated on endosome |
| KEGG:04151 | 0.00654350485448 | 1.0 | MAPK1 MAPK3 | PI3K-Akt signaling pathway |
| WP:WP306 | 0.00654923464894 | 1.0 | MAPK1 MAPK3 | Focal Adhesion |
| REAC:R-HSA-168188 | 0.00656291627866 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168138 | 0.00656291627866 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 0.00656291627866 | 1.0 | MAPK1 MAPK3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168164 | 0.00671207346681 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.00686290657842 | 1.0 | MAPK1 MAPK3 | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.0070154156135 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.0070154156135 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor 2 (TLR2) Cascade |
| KEGG:05165 | 0.00707836525128 | 1.0 | MAPK1 MAPK3 | Human papillomavirus infection |
| REAC:R-HSA-937061 | 0.00716960057204 | 1.0 | MAPK1 MAPK3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.00716960057204 | 1.0 | MAPK1 MAPK3 | MyD88-independent TLR4 cascade |
| WP:WP3888 | 0.00889388896944 | 1.0 | MAPK1 MAPK3 | VEGFA-VEGFR2 Signaling Pathway |
| WP:WP382 | 0.00889388896944 | 1.0 | MAPK1 MAPK3 | MAPK Signaling Pathway |
| REAC:R-HSA-8878166 | 0.00897624606448 | 1.0 | MAPK1 MAPK3 | Transcriptional regulation by RUNX2 |
| REAC:R-HSA-2559582 | 0.00932651406811 | 1.0 | MAPK1 MAPK3 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-373760 | 0.0102315127378 | 1.0 | MAPK1 MAPK3 | L1CAM interactions |
| REAC:R-HSA-166016 | 0.0115688996608 | 1.0 | MAPK1 MAPK3 | Toll Like Receptor 4 (TLR4) Cascade |
| MIRNA:hsa-miR-9-3p | 0.0118707778984 | 1.0 | MAPK1 MAPK3 | hsa-miR-9-3p |
| REAC:R-HSA-2454202 | 0.0119660935214 | 1.0 | MAPK1 MAPK3 | Fc epsilon receptor (FCERI) signaling |
| WP:WP3932 | 0.0121610546673 | 1.0 | MAPK1 MAPK3 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-2559580 | 0.0123699910758 | 1.0 | MAPK1 MAPK3 | Oxidative Stress Induced Senescence |
| GO:0072584 | 0.0126230555186 | 1.0 | MAPK1 MAPK3 | caveolin-mediated endocytosis |
| REAC:R-HSA-416476 | 0.0147112561527 | 1.0 | MAPK1 MAPK3 | G alpha (q) signalling events |
| REAC:R-HSA-6807070 | 0.0151587277172 | 1.0 | MAPK1 MAPK3 | PTEN Regulation |
| WP:WP4172 | 0.015291110435 | 1.0 | MAPK1 MAPK3 | PI3K-Akt Signaling Pathway |
| KEGG:05200 | 0.0157394270613 | 1.0 | MAPK1 MAPK3 | Pathways in cancer |
| REAC:R-HSA-168898 | 0.0163067352889 | 1.0 | MAPK1 MAPK3 | Toll-like Receptor Cascades |
| REAC:R-HSA-109581 | 0.0237914094719 | 1.0 | MAPK1 MAPK3 | Apoptosis |
| REAC:R-HSA-5357801 | 0.0246461304377 | 1.0 | MAPK1 MAPK3 | Programmed Cell Death |
| REAC:R-HSA-112314 | 0.0255159347147 | 1.0 | MAPK1 MAPK3 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | MAPK1 MAPK3 | Cellular Senescence |
| REAC:R-HSA-5673001 | 0.0313749631391 | 1.0 | MAPK1 MAPK3 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0330173681322 | 1.0 | MAPK1 MAPK3 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | MAPK1 MAPK3 | ESR-mediated signaling |
| REAC:R-HSA-9607240 | 0.0371300843089 | 1.0 | MAPK1 MAPK3 | FLT3 Signaling |
| GO:1903358 | 0.0410249304355 | 1.0 | MAPK1 MAPK3 | regulation of Golgi organization |
| GO:0048313 | 0.0410249304355 | 1.0 | MAPK1 MAPK3 | Golgi inheritance |
| GO:0048308 | 0.0410249304355 | 1.0 | MAPK1 MAPK3 | organelle inheritance |
| GO:0004707 | 0.0410249304355 | 1.0 | MAPK1 MAPK3 | MAP kinase activity |
| REAC:R-HSA-76002 | 0.0414841334642 | 1.0 | MAPK1 MAPK3 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | MAPK1 MAPK3 | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 0.0429891127334 | 1.0 | MAPK1 MAPK3 | Other interleukin signaling |
| REAC:R-HSA-112315 | 0.0429891127334 | 1.0 | MAPK1 MAPK3 | Transmission across Chemical Synapses |
| REAC:R-HSA-5683057 | 0.0464733576116 | 1.0 | MAPK1 MAPK3 | MAPK family signaling cascades |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | MAPK1 MAPK3 | Signaling by Nuclear Receptors |
| REAC:R-HSA-111995 | 0.0499173803268 | 0.5 | MAPK1 | phospho-PLA2 pathway |
| CORUM:55 | 0.0499173803268 | 0.5 | MAPK3 | HDAC4-ERK1 complex |
| CORUM:57 | 0.0499173803268 | 0.5 | MAPK1 | HDAC4-ERK2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPK3 | MAPK1 | 0.968 | 0.88 | bioplex_WMM boldt fraction boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_01496 has an average edge precision of 0.88 which is ranked 660 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK1 | HuMAP2_01496 HuMAP2_02168 HuMAP2_03697 |
| MAPK3 | HuMAP2_01496 HuMAP2_03697 HuMAP2_06898 |