hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01499
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] | UniProt NCBI |
| LONP1 | Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) | UniProt NCBI |
| PC | Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01230 | 0.00110943942397 | 0.666666666667 | PC ALDH18A1 | Biosynthesis of amino acids |
| WP:WP3925 | 0.00365767654025 | 0.666666666667 | PC ALDH18A1 | Amino Acid metabolism |
| HP:0002518 | 0.0161338784795 | 0.666666666667 | PC ALDH18A1 | Abnormality of the periventricular white matter |
| HP:0001191 | 0.0183346678183 | 0.666666666667 | ALDH18A1 LONP1 | Abnormality of the carpal bones |
| HP:0001374 | 0.0189067773604 | 0.666666666667 | ALDH18A1 LONP1 | Congenital hip dislocation |
| HP:0000519 | 0.0237990042853 | 0.666666666667 | ALDH18A1 LONP1 | Developmental cataract |
| HP:0002500 | 0.0293567877248 | 1.0 | LONP1 PC ALDH18A1 | Abnormality of the cerebral white matter |
| HP:0025356 | 0.0307019877242 | 0.666666666667 | PC ALDH18A1 | Psychomotor retardation |
| HP:0010993 | 0.0409072271866 | 1.0 | LONP1 PC ALDH18A1 | Abnormality of the cerebral subcortex |
| HP:0003019 | 0.0462248590062 | 0.666666666667 | ALDH18A1 LONP1 | Abnormality of the wrist |
| HP:0003470 | 0.0489637608732 | 0.666666666667 | ALDH18A1 LONP1 | Paralysis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALDH18A1 | LONP1 | 0.493 | 0.62 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PC | ALDH18A1 | 0.125 | 0.399 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| PC | LONP1 | 0.0 | 0.001 | hein_WMM bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_01499 has an average edge precision of 0.34 which is ranked 4122 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ALDH18A1 | HuMAP2_01499 HuMAP2_04069 HuMAP2_05918 |
| LONP1 | HuMAP2_01499 HuMAP2_01826 HuMAP2_05918 |
| PC | HuMAP2_01499 HuMAP2_05918 |