hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01506
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PAK5 | Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | UniProt NCBI |
| PAK6 | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428540 | 1.28584716548e-07 | 1.0 | PAK5 PAK4 PAK6 | Activation of RAC1 |
| WP:WP4564 | 3.85431460229e-07 | 1.0 | PAK5 PAK4 PAK6 | Neural Crest Cell Migration during Development |
| WP:WP4565 | 5.00468323191e-07 | 1.0 | PAK5 PAK4 PAK6 | Neural Crest Cell Migration in Cancer |
| WP:WP4534 | 6.8661419887e-07 | 1.0 | PAK5 PAK4 PAK6 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| KEGG:05211 | 1.19420412995e-06 | 1.0 | PAK5 PAK4 PAK6 | Renal cell carcinoma |
| WP:WP4205 | 1.88464647832e-06 | 1.0 | PAK5 PAK4 PAK6 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04012 | 2.37809343488e-06 | 1.0 | PAK5 PAK4 PAK6 | ErbB signaling pathway |
| KEGG:04660 | 3.53290275205e-06 | 1.0 | PAK5 PAK4 PAK6 | T cell receptor signaling pathway |
| WP:WP4263 | 5.91808622949e-06 | 1.0 | PAK5 PAK4 PAK6 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 6.36180904525e-06 | 1.0 | PAK5 PAK4 PAK6 | ErbB Signaling Pathway |
| WP:WP4541 | 1.10592549668e-05 | 1.0 | PAK5 PAK4 PAK6 | Hippo-Merlin Signaling Dysregulation |
| KEGG:04360 | 2.21071058913e-05 | 1.0 | PAK5 PAK4 PAK6 | Axon guidance |
| WP:WP51 | 2.41319770871e-05 | 1.0 | PAK5 PAK4 PAK6 | Regulation of Actin Cytoskeleton |
| KEGG:04014 | 3.07154438585e-05 | 1.0 | PAK5 PAK4 PAK6 | Ras signaling pathway |
| KEGG:04810 | 3.2250969458e-05 | 1.0 | PAK5 PAK4 PAK6 | Regulation of actin cytoskeleton |
| KEGG:04510 | 3.33025703802e-05 | 1.0 | PAK5 PAK4 PAK6 | Focal adhesion |
| KEGG:05170 | 3.89046029743e-05 | 1.0 | PAK5 PAK4 PAK6 | Human immunodeficiency virus 1 infection |
| WP:WP4223 | 3.92056063451e-05 | 1.0 | PAK5 PAK4 PAK6 | Ras Signaling |
| REAC:R-HSA-376176 | 0.00071395360032 | 1.0 | PAK5 PAK4 PAK6 | Signaling by ROBO receptors |
| WP:WP185 | 0.00408673569856 | 0.666666666667 | PAK6 PAK4 | Integrin-mediated Cell Adhesion |
| REAC:R-HSA-422475 | 0.0100572742862 | 1.0 | PAK5 PAK4 PAK6 | Axon guidance |
| WP:WP306 | 0.0167204021762 | 0.666666666667 | PAK6 PAK4 | Focal Adhesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PAK5 | PAK4 | 1.0 | 0.949 | bioplex (PAK4,PAK5) bioplex_WMM |
| PAK4 | PAK6 | 1.0 | 0.949 | bioplex (PAK4) bioplex_WMM |
| PAK5 | PAK6 | 0.009 | 0.108 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_01506 has an average edge precision of 0.669 which is ranked 1524 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PAK5 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |
| PAK4 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |
| PAK6 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |