hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01514
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP6V1A | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) | UniProt NCBI |
| ATP6V1B2 | V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2) | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6888 | 0.000457035673196 | 0.5 | ATP6V1A ATP6V1B2 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| KEGG:04966 | 0.00059986074407 | 0.5 | ATP6V1A ATP6V1B2 | Collecting duct acid secretion |
| KEGG:05110 | 0.00225083015122 | 0.5 | ATP6V1A ATP6V1B2 | Vibrio cholerae infection |
| REAC:R-HSA-77387 | 0.00276986547413 | 0.5 | ATP6V1A ATP6V1B2 | Insulin receptor recycling |
| KEGG:05323 | 0.00307073724034 | 0.5 | ATP6V1A ATP6V1B2 | Rheumatoid arthritis |
| KEGG:05120 | 0.00364735612249 | 0.5 | ATP6V1A ATP6V1B2 | Epithelial cell signaling in Helicobacter pylori infection |
| REAC:R-HSA-917977 | 0.00407268683926 | 0.5 | ATP6V1A ATP6V1B2 | Transferrin endocytosis and recycling |
| KEGG:04721 | 0.00440435122993 | 0.5 | ATP6V1A ATP6V1B2 | Synaptic vesicle cycle |
| REAC:R-HSA-1222556 | 0.00497416142364 | 0.5 | ATP6V1A ATP6V1B2 | ROS and RNS production in phagocytes |
| KEGG:00190 | 0.0136880283161 | 0.5 | ATP6V1A ATP6V1B2 | Oxidative phosphorylation |
| REAC:R-HSA-917937 | 0.0143225711665 | 0.5 | ATP6V1A ATP6V1B2 | Iron uptake and transport |
| REAC:R-HSA-74752 | 0.017117349746 | 0.5 | ATP6V1A ATP6V1B2 | Signaling by Insulin receptor |
| KEGG:04145 | 0.0179080093657 | 0.5 | ATP6V1A ATP6V1B2 | Phagosome |
| KEGG:04150 | 0.0203683297936 | 0.5 | ATP6V1A ATP6V1B2 | mTOR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6V1B2 | ATP6V1A | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction treiber_WMM |
| ATP6V1A | CAPN2 | 0.043 | 0.269 | fraction treiber_WMM |
| ATP6V1A | OGDHL | 0.039 | 0.266 | Guru fraction |
| ATP6V1B2 | CAPN2 | 0.026 | 0.22 | fraction treiber_WMM |
Images
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Complex HuMAP2_01514 has an average edge precision of 0.426 which is ranked 3060 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATP6V1A | HuMAP2_00849 HuMAP2_01065 HuMAP2_01514 HuMAP2_04825 HuMAP2_05288 HuMAP2_05478 HuMAP2_06925 |
| ATP6V1B2 | HuMAP2_00772 HuMAP2_01065 HuMAP2_01514 HuMAP2_06925 |
| CAPN2 | HuMAP2_01514 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |