hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01515
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CWC27 | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | UniProt NCBI |
| LSM2 | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | UniProt NCBI |
| DDX39B | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | UniProt NCBI |
| LSM1 | U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm) | UniProt NCBI |
| LSM3 | U6 snRNA-associated Sm-like protein LSm3 | UniProt NCBI |
| LSM6 | U6 snRNA-associated Sm-like protein LSm6 | UniProt NCBI |
| LSM7 | U6 snRNA-associated Sm-like protein LSm7 | UniProt NCBI |
| LSM8 | U6 snRNA-associated Sm-like protein LSm8 | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005688 | 4.46966480611e-19 | 0.777777777778 | DDX39B LSM2 LSM7 LSM8 LSM6 LSM4 LSM3 | U6 snRNP |
| CORUM:562 | 1.60394245013e-18 | 0.666666666667 | LSM2 LSM7 LSM3 LSM6 LSM8 LSM4 | LSm2-8 complex |
| CORUM:561 | 1.60394245013e-18 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | LSm1-7 complex |
| GO:0120115 | 1.94077036466e-15 | 0.666666666667 | LSM2 LSM7 LSM3 LSM6 LSM8 LSM4 | Lsm2-8 complex |
| REAC:R-HSA-430039 | 5.52085304142e-15 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | mRNA decay by 5' to 3' exoribonuclease |
| GO:0120114 | 1.12693694016e-13 | 0.888888888889 | DDX39B LSM2 LSM7 LSM4 LSM1 LSM6 LSM8 LSM3 | Sm-like protein family complex |
| KEGG:03018 | 1.24022214835e-13 | 0.777777777778 | LSM2 LSM7 LSM4 LSM1 LSM6 LSM8 LSM3 | RNA degradation |
| GO:0071005 | 5.55310186732e-12 | 0.777777777778 | CWC27 LSM2 LSM7 LSM4 LSM6 LSM8 LSM3 | U2-type precatalytic spliceosome |
| KEGG:03040 | 5.9546721807e-12 | 0.777777777778 | DDX39B LSM2 LSM7 LSM8 LSM6 LSM4 LSM3 | Spliceosome |
| REAC:R-HSA-72203 | 6.03358298557e-12 | 0.888888888889 | CWC27 LSM2 LSM3 LSM7 LSM4 LSM6 LSM8 DDX39B | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0071011 | 6.43579137436e-12 | 0.777777777778 | CWC27 LSM2 LSM7 LSM4 LSM6 LSM8 LSM3 | precatalytic spliceosome |
| GO:0097525 | 1.46864834283e-11 | 0.777777777778 | DDX39B LSM2 LSM7 LSM8 LSM6 LSM4 LSM3 | spliceosomal snRNP complex |
| GO:0030532 | 3.07121357463e-11 | 0.777777777778 | DDX39B LSM2 LSM7 LSM8 LSM6 LSM4 LSM3 | small nuclear ribonucleoprotein complex |
| REAC:R-HSA-429914 | 3.55617271408e-11 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | Deadenylation-dependent mRNA decay |
| GO:0000375 | 3.78117319965e-11 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | RNA splicing, via transesterification reactions |
| GO:0005681 | 6.97957619619e-11 | 0.888888888889 | CWC27 LSM2 LSM3 LSM7 LSM4 LSM6 LSM8 DDX39B | spliceosomal complex |
| REAC:R-HSA-8953854 | 1.11529071369e-10 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | Metabolism of RNA |
| GO:0008380 | 1.63738303206e-10 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | RNA splicing |
| GO:0046540 | 1.63972676246e-10 | 0.666666666667 | LSM2 LSM7 LSM3 LSM6 LSM8 LSM4 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 1.63972676246e-10 | 0.666666666667 | LSM2 LSM7 LSM3 LSM6 LSM8 LSM4 | spliceosomal tri-snRNP complex |
| REAC:R-HSA-72163 | 2.17483287425e-10 | 0.777777777778 | CWC27 LSM2 LSM7 LSM4 LSM6 LSM8 LSM3 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 2.97112930155e-10 | 0.777777777778 | CWC27 LSM2 LSM7 LSM4 LSM6 LSM8 LSM3 | mRNA Splicing |
| GO:0043928 | 3.05699419639e-10 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | exonucleolytic catabolism of deadenylated mRNA |
| GO:0006397 | 3.17906821833e-10 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | mRNA processing |
| GO:0005684 | 4.47816122582e-10 | 0.777777777778 | CWC27 LSM2 LSM7 LSM4 LSM6 LSM8 LSM3 | U2-type spliceosomal complex |
| GO:0000291 | 4.4785279023e-10 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | nuclear-transcribed mRNA catabolic process, exonucleolytic |
| GO:0017070 | 4.76228219893e-10 | 0.555555555556 | LSM4 LSM2 DDX39B LSM7 LSM8 | U6 snRNA binding |
| CORUM:351 | 2.10067606801e-09 | 0.666666666667 | DDX39B LSM2 LSM7 LSM3 LSM6 LSM4 | Spliceosome |
| GO:0000377 | 1.4994353251e-08 | 0.888888888889 | CWC27 LSM2 LSM3 LSM7 LSM4 LSM6 LSM8 DDX39B | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 1.4994353251e-08 | 0.888888888889 | CWC27 LSM2 LSM3 LSM7 LSM4 LSM6 LSM8 DDX39B | mRNA splicing, via spliceosome |
| GO:1990726 | 1.53650749201e-08 | 0.444444444444 | LSM2 LSM3 LSM1 LSM7 | Lsm1-7-Pat1 complex |
| GO:0000288 | 3.59581481224e-08 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:0016071 | 6.29083046031e-08 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | mRNA metabolic process |
| GO:1990904 | 1.0309341313e-07 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | ribonucleoprotein complex |
| GO:0006396 | 1.29165543003e-07 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | RNA processing |
| GO:0017069 | 4.46710734245e-07 | 0.555555555556 | LSM4 LSM2 DDX39B LSM7 LSM8 | snRNA binding |
| GO:0000932 | 8.41177381502e-06 | 0.555555555556 | LSM4 LSM6 LSM3 LSM1 LSM2 | P-body |
| GO:0000956 | 2.01665656786e-05 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | nuclear-transcribed mRNA catabolic process |
| CORUM:0000000 | 7.29350199909e-05 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | CORUM root |
| CORUM:1181 | 0.000468877519279 | 0.333333333333 | LSM2 CWC27 LSM3 | C complex spliceosome |
| GO:0006402 | 0.000509216019936 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | mRNA catabolic process |
| GO:0006401 | 0.000848050428807 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | RNA catabolic process |
| CORUM:5613 | 0.00160250387659 | 0.222222222222 | LSM2 LSM8 | Emerin complex 25 |
| GO:0036464 | 0.00160514561408 | 0.555555555556 | LSM4 LSM6 LSM3 LSM1 LSM2 | cytoplasmic ribonucleoprotein granule |
| GO:0035770 | 0.00209562513757 | 0.555555555556 | LSM4 LSM6 LSM3 LSM1 LSM2 | ribonucleoprotein granule |
| GO:0003723 | 0.00290511141072 | 0.888888888889 | DDX39B LSM2 LSM7 LSM4 LSM1 LSM6 LSM8 LSM3 | RNA binding |
| GO:0034655 | 0.0032198215207 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | nucleobase-containing compound catabolic process |
| GO:0046700 | 0.00498465773508 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | heterocycle catabolic process |
| GO:0044270 | 0.00504492359649 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | cellular nitrogen compound catabolic process |
| GO:0071013 | 0.00552971800691 | 0.444444444444 | LSM2 LSM3 CWC27 LSM7 | catalytic step 2 spliceosome |
| GO:0019439 | 0.00581647045156 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | aromatic compound catabolic process |
| GO:1901361 | 0.00731851242279 | 0.666666666667 | LSM2 LSM7 LSM3 LSM1 LSM6 LSM4 | organic cyclic compound catabolic process |
| GO:0016070 | 0.0374962393684 | 1.0 | LSM4 CWC27 LSM2 LSM3 LSM7 LSM1 LSM6 LSM8 DDX39B | RNA metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSM8 | LSM2 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM8 | LSM6 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM6 | 1.0 | 0.949 | youn (LSM2) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM6 | LSM3 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM8 | LSM3 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM3 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| LSM8 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM4 | 1.0 | 0.949 | youn (LSM2,LSM4) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| LSM6 | LSM7 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM3 | LSM7 | 0.999 | 0.949 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM3 | CWC27 | 0.988 | 0.901 | bioplex_WMM youn_WMM fraction |
| LSM4 | LSM3 | 0.959 | 0.863 | youn (LSM4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM |
| LSM2 | LSM7 | 0.952 | 0.858 | youn (LSM2) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM8 | LSM7 | 0.945 | 0.856 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | CWC27 | 0.88 | 0.813 | bioplex_WMM youn_WMM fraction |
| LSM2 | CWC27 | 0.849 | 0.79 | bioplex_WMM youn_WMM fraction |
| LSM6 | DDX39B | 0.825 | 0.774 | bioplex (LSM6) bioplex_WMM youn_WMM fraction |
| LSM6 | LSM1 | 0.634 | 0.684 | youn (LSM1) bioplex (LSM6) bioplex_WMM youn_WMM |
| LSM2 | DDX39B | 0.632 | 0.681 | youn (LSM2) bioplex_WMM youn_WMM gupta_WMM fraction |
| LSM3 | DDX39B | 0.175 | 0.434 | bioplex_WMM youn_WMM gupta_WMM fraction |
| LSM4 | LSM1 | 0.09 | 0.355 | youn (LSM1,LSM4) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM treiber_WMM |
| LSM4 | CWC27 | 0.035 | 0.261 | bioplex_WMM youn_WMM fraction |
| LSM8 | LSM1 | 0.013 | 0.149 | youn (LSM1) bioplex_WMM youn_WMM |
| LSM8 | DDX39B | 0.01 | 0.13 | bioplex_WMM youn_WMM fraction |
| LSM2 | LSM1 | 0.01 | 0.098 | youn (LSM1,LSM2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM4 | DDX39B | 0.008 | 0.091 | youn (LSM4) bioplex_WMM youn_WMM gupta_WMM fraction |
| LSM1 | LSM7 | 0.008 | 0.085 | youn (LSM1) bioplex_WMM youn_WMM treiber_WMM |
| DDX39B | CWC27 | 0.008 | 0.041 | bioplex_WMM youn_WMM fraction |
| LSM8 | CWC27 | 0.008 | 0.031 | bioplex_WMM youn_WMM fraction |
| LSM1 | DDX39B | 0.007 | 0.005 | youn (LSM1) bioplex_WMM youn_WMM |
| LSM7 | DDX39B | 0.006 | 0.0 | youn_WMM fraction |
| LSM4 | LSM7 | 0.005 | 0.007 | youn (LSM4) bioplex_WMM Guru youn_WMM fraction boldt_WMM treiber_WMM |
| LSM7 | CWC27 | 0.0 | 0.008 | youn_WMM fraction |
| LSM1 | LSM3 | 0.0 | 0.002 | youn (LSM1) bioplex_WMM Guru youn_WMM fraction |
| LSM1 | CWC27 | 0.0 | 0.0 | bioplex_WMM fraction |
Images
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Complex HuMAP2_01515 has an average edge precision of 0.538 which is ranked 2290 out of all 6965 complexes.
Related Complexes