hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01516
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SETDB1 | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | UniProt NCBI |
| ATF7IP | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | UniProt NCBI |
| MCUB | Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2749 | 3.35600554376e-06 | 0.666666666667 | SETDB1 ATF7IP | SETDB1-containing HMTase complex |
| CORUM:2238 | 1.00675659188e-05 | 0.666666666667 | SETDB1 ATF7IP | MBD1-MCAF1-SETDB1 complex |
| REAC:R-HSA-3214841 | 0.0165866686159 | 0.666666666667 | SETDB1 ATF7IP | PKMTs methylate histone lysines |
| CORUM:2759 | 0.0499776345577 | 0.333333333333 | ATF7IP | MBD1-MCAF complex |
| CORUM:6422 | 0.0499776345577 | 0.333333333333 | SETDB1 | SETDB1-DNMT3A complex |
| CORUM:6423 | 0.0499776345577 | 0.333333333333 | SETDB1 | SETDB1-DNMT3B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATF7IP | SETDB1 | 0.995 | 0.924 | hein_WMM bioplex (ATF7IP,SETDB1) bioplex_WMM Guru hein (SETDB1) Malo fraction |
| MCUB | SETDB1 | 0.863 | 0.8 | bioplex (SETDB1) bioplex_WMM |
| ATF7IP | MCUB | 0.008 | 0.012 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01516 has an average edge precision of 0.579 which is ranked 2038 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SETDB1 | HuMAP2_00567 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 |
| ATF7IP | HuMAP2_00567 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 |
| MCUB | HuMAP2_00567 HuMAP2_00894 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 HuMAP2_04380 |