hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01521
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DDOST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) | UniProt NCBI |
| MAGT1 | Magnesium transporter protein 1 (MagT1) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1) (Oligosaccharyl transferase subunit MAGT1) (Implantation-associated protein) (IAP) | UniProt NCBI |
| PGRMC2 | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | UniProt NCBI |
| SEC61A1 | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) | UniProt NCBI |
| SEC63 | Translocation protein SEC63 homolog | UniProt NCBI |
| JAGN1 | Protein jagunal homolog 1 | UniProt NCBI |
| RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | UniProt NCBI |
| CANX | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1199 | 9.41110885571e-08 | 0.375 | DDOST RPN1 MAGT1 | Oligosaccharyltransferase complex (Stt3A variant) |
| CORUM:1200 | 1.64652925394e-07 | 0.375 | DDOST RPN1 MAGT1 | Oligosaccharyltransferase complex (Stt3B variant) |
| KEGG:04141 | 3.20477982005e-07 | 0.625 | SEC63 CANX RPN1 DDOST SEC61A1 | Protein processing in endoplasmic reticulum |
| CORUM:6131 | 5.64097851901e-07 | 0.375 | DDOST RPN1 CANX | SELK multiprotein complex |
| GO:0004579 | 0.000426565421795 | 0.375 | DDOST RPN1 MAGT1 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| GO:0004576 | 0.000609225680053 | 0.375 | DDOST RPN1 MAGT1 | oligosaccharyl transferase activity |
| GO:0008250 | 0.000837474301274 | 0.375 | DDOST RPN1 MAGT1 | oligosaccharyltransferase complex |
| REAC:R-HSA-446203 | 0.0015337118184 | 0.5 | DDOST MAGT1 RPN1 CANX | Asparagine N-linked glycosylation |
| KEGG:03060 | 0.00305352336835 | 0.25 | SEC63 SEC61A1 | Protein export |
| REAC:R-HSA-1799339 | 0.00389285199534 | 0.375 | DDOST RPN1 SEC61A1 | SRP-dependent cotranslational protein targeting to membrane |
| KEGG:00513 | 0.00757711563585 | 0.25 | DDOST RPN1 | Various types of N-glycan biosynthesis |
| GO:0005789 | 0.0105974815608 | 0.75 | CANX SEC63 MAGT1 SEC61A1 DDOST RPN1 | endoplasmic reticulum membrane |
| KEGG:00510 | 0.0113532598614 | 0.25 | DDOST RPN1 | N-Glycan biosynthesis |
| GO:0042175 | 0.0116723837041 | 0.75 | CANX SEC63 MAGT1 SEC61A1 DDOST RPN1 | nuclear outer membrane-endoplasmic reticulum membrane network |
| GO:0005783 | 0.0150592158305 | 0.875 | RPN1 CANX SEC63 MAGT1 DDOST JAGN1 SEC61A1 | endoplasmic reticulum |
| GO:0018279 | 0.0205085054668 | 0.375 | DDOST RPN1 MAGT1 | protein N-linked glycosylation via asparagine |
| GO:0018196 | 0.0227001216234 | 0.375 | DDOST RPN1 MAGT1 | peptidyl-asparagine modification |
| HP:0001871 | 0.0397629471445 | 0.625 | SEC63 MAGT1 JAGN1 DDOST SEC61A1 | Abnormality of blood and blood-forming tissues |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DDOST | RPN1 | 0.339 | 0.528 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| MAGT1 | DDOST | 0.205 | 0.454 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| RPN1 | CANX | 0.109 | 0.378 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SEC61A1 | DDOST | 0.087 | 0.353 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RPN1 | PGRMC2 | 0.039 | 0.264 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| JAGN1 | DDOST | 0.029 | 0.232 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SEC61A1 | SEC63 | 0.028 | 0.231 | bioplex (SEC63) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAGT1 | SEC61A1 | 0.026 | 0.22 | bioplex (SEC61A1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| JAGN1 | SEC61A1 | 0.026 | 0.22 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| JAGN1 | PGRMC2 | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| MAGT1 | JAGN1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| JAGN1 | RPN1 | 0.007 | 0.005 | youn_WMM gupta_WMM WMM_only |
| JAGN1 | CANX | 0.007 | 0.003 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| JAGN1 | SEC63 | 0.007 | 0.0 | youn_WMM gupta_WMM WMM_only |
| DDOST | PGRMC2 | 0.007 | 0.005 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC61A1 | PGRMC2 | 0.005 | 0.009 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC63 | RPN1 | 0.005 | 0.008 | bioplex (SEC63) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| MAGT1 | PGRMC2 | 0.005 | 0.01 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC63 | CANX | 0.004 | 0.01 | bioplex (SEC63) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| SEC61A1 | CANX | 0.004 | 0.014 | bioplex (SEC61A1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC63 | DDOST | 0.004 | 0.017 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC61A1 | RPN1 | 0.003 | 0.021 | bioplex (SEC61A1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MAGT1 | RPN1 | 0.003 | 0.005 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MAGT1 | SEC63 | 0.003 | 0.011 | bioplex_WMM youn_WMM gupta_WMM fraction |
| DDOST | CANX | 0.0 | 0.014 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| CANX | PGRMC2 | 0.0 | 0.017 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAGT1 | CANX | 0.0 | 0.012 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC63 | PGRMC2 | 0.0 | 0.009 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_01521 has an average edge precision of 0.109 which is ranked 6914 out of all 6965 complexes.
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