hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01528
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LLGL1 | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | UniProt NCBI |
| PARD3 | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | UniProt NCBI |
| RGL1 | Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) | UniProt NCBI |
| PRKCZ | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | UniProt NCBI |
| PRKCI | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | UniProt NCBI |
| PARD6A | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | UniProt NCBI |
| PARD6B | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | UniProt NCBI |
| PARD6G | Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) | UniProt NCBI |
| BRWD3 | Bromodomain and WD repeat-containing protein 3 | UniProt NCBI |
| LLGL2 | Lethal(2) giant larvae protein homolog 2 (HGL) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04390 | 1.19129610647e-13 | 0.8 | PARD3 LLGL2 PRKCZ PARD6B PARD6A PARD6G LLGL1 PRKCI | Hippo signaling pathway |
| KEGG:04530 | 1.41363130437e-13 | 0.8 | PARD3 LLGL2 PRKCZ PARD6B PARD6A PARD6G LLGL1 PRKCI | Tight junction |
| REAC:R-HSA-420029 | 2.58659411931e-11 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | Tight junction interactions |
| KEGG:05165 | 7.07798586597e-11 | 0.8 | PARD3 LLGL2 PRKCZ PARD6B PARD6A PARD6G LLGL1 PRKCI | Human papillomavirus infection |
| GO:0007163 | 2.81595540065e-10 | 0.8 | PARD3 LLGL2 PRKCZ PARD6B PARD6A PARD6G LLGL1 PRKCI | establishment or maintenance of cell polarity |
| REAC:R-HSA-421270 | 9.27847754533e-09 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | Cell-cell junction organization |
| CORUM:959 | 1.62176028613e-08 | 0.3 | PRKCI PARD6B LLGL1 | LLGL1-PAR-6B-PRKCI complex |
| CORUM:956 | 1.62176028613e-08 | 0.3 | PRKCI PARD6B PARD3 | PAR-3-PAR-6B-PRKCI complex |
| CORUM:955 | 1.62176028613e-08 | 0.3 | PRKCI PARD6B LLGL2 | LLGL2-PAR-6B-PRKCI complex |
| KEGG:04015 | 2.18756690908e-08 | 0.6 | PARD3 PRKCZ PARD6B PARD6A PARD6G PRKCI | Rap1 signaling pathway |
| CORUM:7444 | 6.48475406063e-08 | 0.3 | PARD3 PRKCI PARD6A | HOOK2-PAR3-Par6alpha-PKCiota complex |
| REAC:R-HSA-446728 | 1.10398002625e-07 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | Cell junction organization |
| KEGG:04144 | 1.25062444697e-07 | 0.6 | PARD3 PRKCZ PARD6B PARD6A PARD6G PRKCI | Endocytosis |
| CORUM:905 | 1.62061692851e-07 | 0.3 | PARD3 PRKCI PARD6A | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| REAC:R-HSA-1500931 | 7.35631807034e-07 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | Cell-Cell communication |
| GO:0070830 | 1.53150866514e-06 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | bicellular tight junction assembly |
| GO:0120192 | 1.73798191785e-06 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | tight junction assembly |
| KEGG:04360 | 1.81929360219e-06 | 0.5 | PARD3 PRKCZ PARD6G PARD6B PARD6A | Axon guidance |
| GO:0120193 | 2.21755613333e-06 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | tight junction organization |
| GO:0043297 | 3.4924908421e-06 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | apical junction assembly |
| REAC:R-HSA-2173791 | 2.06600520876e-05 | 0.3 | PARD3 PRKCZ PARD6A | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| GO:0005938 | 5.14085362248e-05 | 0.6 | PARD3 LLGL2 PARD6B PARD6A PARD6G LLGL1 | cell cortex |
| CORUM:918 | 9.0534767973e-05 | 0.2 | PARD6A PARD3 | PAR3-PAR6-PALS1 complex |
| CORUM:5534 | 9.0534767973e-05 | 0.2 | PARD6A PARD3 | PLCB1-PARD3-PARD6A complex |
| CORUM:5535 | 9.0534767973e-05 | 0.2 | PARD6A PARD3 | PLCB3-PARD3-PARD6A complex |
| CORUM:7300 | 9.0534767973e-05 | 0.2 | PRKCI PARD6A | PARD3B-PARD6A-PRKCI complex |
| CORUM:831 | 9.0534767973e-05 | 0.2 | PARD6A PARD3 | PAR-6-PAR-3-VE-cadherin complex, endothelial |
| CORUM:847 | 9.0534767973e-05 | 0.2 | PRKCI PARD3 | RICH1-PAR3-aPKC polarity complex |
| GO:0007043 | 9.37142326991e-05 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | cell-cell junction assembly |
| GO:0045216 | 0.000245325031251 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | cell-cell junction organization |
| GO:0017016 | 0.000519589095925 | 0.6 | LLGL2 RGL1 PARD6B PARD6A PARD6G LLGL1 | Ras GTPase binding |
| GO:0099568 | 0.0005989919036 | 0.6 | PARD3 LLGL2 PARD6B PARD6A PARD6G LLGL1 | cytoplasmic region |
| GO:0031267 | 0.000729675273802 | 0.6 | LLGL2 RGL1 PARD6B PARD6A PARD6G LLGL1 | small GTPase binding |
| GO:0007010 | 0.00101959286507 | 0.8 | PARD3 LLGL2 PARD6A BRWD3 PARD6B PRKCI PARD6G LLGL1 | cytoskeleton organization |
| REAC:R-HSA-170834 | 0.00223342075732 | 0.3 | PARD3 PRKCZ PARD6A | Signaling by TGF-beta Receptor Complex |
| GO:0051020 | 0.00307299716049 | 0.6 | LLGL2 RGL1 PARD6B PARD6A PARD6G LLGL1 | GTPase binding |
| GO:0034329 | 0.00344770843226 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | cell junction assembly |
| REAC:R-HSA-9006936 | 0.00502355965385 | 0.3 | PARD3 PRKCZ PARD6A | Signaling by TGF-beta family members |
| GO:0034330 | 0.00779304808259 | 0.5 | PARD3 PRKCI PARD6G PARD6B PARD6A | cell junction organization |
| GO:0000226 | 0.00783993418531 | 0.6 | PARD3 LLGL2 PARD6B PARD6A PARD6G LLGL1 | microtubule cytoskeleton organization |
| WP:WP2012 | 0.00816086245592 | 0.2 | PRKCZ PRKCI | miRs in Muscle Cell Differentiation |
| GO:0030010 | 0.0158370595379 | 0.4 | PRKCZ LLGL2 LLGL1 PARD3 | establishment of cell polarity |
| GO:0007017 | 0.0489208751818 | 0.6 | PARD3 LLGL2 PARD6B PARD6A PARD6G LLGL1 | microtubule-based process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKCZ | PARD6B | 1.0 | 0.949 | hein_WMM bioplex (PARD6B,PRKCZ) bioplex_WMM hein (PARD6B) |
| PARD6B | PARD3 | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B) |
| PRKCI | PARD6B | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B,PRKCI) |
| PARD6B | LLGL2 | 1.0 | 0.949 | hein_WMM bioplex (LLGL2,PARD6B) bioplex_WMM hein (LLGL2,PARD6B) |
| PARD6B | LLGL1 | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (LLGL1,PARD6B) |
| PRKCI | LLGL2 | 0.988 | 0.901 | hein_WMM bioplex (LLGL2) bioplex_WMM hein (LLGL2,PRKCI) fraction |
| PRKCI | LLGL1 | 0.844 | 0.788 | hein_WMM bioplex_WMM hein (LLGL1,PRKCI) Malo gupta_WMM fraction treiber_WMM |
| PRKCZ | PARD6G | 0.836 | 0.779 | bioplex (PRKCZ) bioplex_WMM |
| BRWD3 | LLGL2 | 0.396 | 0.556 | bioplex (LLGL2) bioplex_WMM |
| PRKCZ | PARD6A | 0.215 | 0.464 | bioplex (PRKCZ) bioplex_WMM |
| PARD6G | LLGL2 | 0.194 | 0.447 | bioplex (LLGL2) bioplex_WMM |
| PRKCI | PARD3 | 0.157 | 0.415 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRKCI) gupta_WMM boldt_WMM |
| RGL1 | LLGL2 | 0.154 | 0.414 | bioplex (LLGL2) bioplex_WMM |
| PRKCZ | PRKCI | 0.068 | 0.35 | hein_WMM bioplex (PRKCZ) bioplex_WMM |
| PRKCZ | LLGL1 | 0.051 | 0.296 | hein_WMM bioplex (PRKCZ) bioplex_WMM |
| PRKCZ | LLGL2 | 0.043 | 0.273 | hein_WMM bioplex (LLGL2,PRKCZ) bioplex_WMM |
| PARD6A | LLGL2 | 0.043 | 0.271 | hein_WMM bioplex (LLGL2) bioplex_WMM Guru hein (LLGL2) fraction |
| PRKCI | PARD6A | 0.043 | 0.27 | hein_WMM bioplex_WMM hein (PRKCI) |
| PARD6G | PARD6B | 0.012 | 0.15 | bioplex_WMM WMM_only |
| PARD6B | PARD6A | 0.012 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| PARD6G | PRKCI | 0.012 | 0.147 | bioplex_WMM WMM_only boldt_WMM |
| PARD6G | PARD6A | 0.01 | 0.128 | bioplex_WMM WMM_only |
| PARD3 | LLGL2 | 0.009 | 0.091 | hein_WMM bioplex_WMM WMM_only |
| BRWD3 | RGL1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| PRKCZ | PARD3 | 0.009 | 0.097 | hein_WMM bioplex_WMM WMM_only |
| PARD6A | RGL1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PARD6A | BRWD3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PARD6G | BRWD3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PARD6G | RGL1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PRKCZ | BRWD3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PRKCZ | RGL1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PARD3 | LLGL1 | 0.008 | 0.085 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PARD6A | LLGL1 | 0.008 | 0.079 | hein_WMM bioplex_WMM WMM_only |
| PARD6B | BRWD3 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| PARD6B | RGL1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| PRKCI | BRWD3 | 0.008 | 0.061 | bioplex_WMM WMM_only |
| PRKCI | RGL1 | 0.008 | 0.061 | bioplex_WMM WMM_only |
| LLGL1 | LLGL2 | 0.008 | 0.025 | hein_WMM bioplex (LLGL2) bioplex_WMM |
| PARD6G | LLGL1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| PARD6G | PARD3 | 0.007 | 0.005 | WMM_only boldt_WMM |
| PARD3 | PARD6A | 0.007 | 0.004 | hein_WMM WMM_only |
Images
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Complex HuMAP2_01528 has an average edge precision of 0.313 which is ranked 4426 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LLGL1 | HuMAP2_01528 HuMAP2_02503 |
| PARD3 | HuMAP2_01053 HuMAP2_01276 HuMAP2_01528 HuMAP2_02149 HuMAP2_02503 HuMAP2_05511 |
| RGL1 | HuMAP2_01528 HuMAP2_02503 |
| PRKCZ | HuMAP2_00362 HuMAP2_00450 HuMAP2_01528 HuMAP2_02503 |
| PRKCI | HuMAP2_00450 HuMAP2_01276 HuMAP2_01528 HuMAP2_02503 |
| PARD6A | HuMAP2_01528 HuMAP2_02503 |
| PARD6B | HuMAP2_00450 HuMAP2_01276 HuMAP2_01528 HuMAP2_02149 HuMAP2_02503 HuMAP2_05511 |
| PARD6G | HuMAP2_00362 HuMAP2_01239 HuMAP2_01528 HuMAP2_02503 |
| BRWD3 | HuMAP2_01528 HuMAP2_02503 |
| LLGL2 | HuMAP2_01528 HuMAP2_02503 |