hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01552
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKR1C1 | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid-binding protein) (HBAB) (Indanol dehydrogenase) (EC 1.1.1.112) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) | UniProt NCBI |
| AKR1C2 | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP696 | 1.04322772881e-05 | 1.0 | AKR1C2 AKR1C1 | Benzo(a)pyrene metabolism |
| REAC:R-HSA-193775 | 0.000130722030065 | 1.0 | AKR1C2 AKR1C1 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| REAC:R-HSA-193807 | 0.000130722030065 | 1.0 | AKR1C2 AKR1C1 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| KEGG:00140 | 0.000138019076752 | 1.0 | AKR1C2 AKR1C1 | Steroid hormone biosynthesis |
| WP:WP98 | 0.000221685892372 | 1.0 | AKR1C2 AKR1C1 | Prostaglandin Synthesis and Regulation |
| REAC:R-HSA-193368 | 0.000351943927099 | 1.0 | AKR1C2 AKR1C1 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| GO:0047115 | 0.000450823411379 | 1.0 | AKR1C2 AKR1C1 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
| REAC:R-HSA-192105 | 0.000729026706133 | 1.0 | AKR1C2 AKR1C1 | Synthesis of bile acids and bile salts |
| REAC:R-HSA-194068 | 0.0010558317813 | 1.0 | AKR1C2 AKR1C1 | Bile acid and bile salt metabolism |
| GO:0018636 | 0.00135247023414 | 1.0 | AKR1C2 AKR1C1 | phenanthrene 9,10-monooxygenase activity |
| GO:0009753 | 0.00270494046827 | 1.0 | AKR1C2 AKR1C1 | response to jasmonic acid |
| GO:0071395 | 0.00270494046827 | 1.0 | AKR1C2 AKR1C1 | cellular response to jasmonic acid stimulus |
| GO:0047086 | 0.00450823411379 | 1.0 | AKR1C2 AKR1C1 | ketosteroid monooxygenase activity |
| WP:WP702 | 0.00467999410771 | 1.0 | AKR1C2 AKR1C1 | Metapathway biotransformation Phase I and II |
| GO:0047023 | 0.00946729163895 | 1.0 | AKR1C2 AKR1C1 | androsterone dehydrogenase activity |
| GO:0032052 | 0.00946729163895 | 1.0 | AKR1C2 AKR1C1 | bile acid binding |
| REAC:R-HSA-8957322 | 0.0131978972662 | 1.0 | AKR1C2 AKR1C1 | Metabolism of steroids |
| GO:0044598 | 0.0162296428096 | 1.0 | AKR1C2 AKR1C1 | doxorubicin metabolic process |
| GO:0030647 | 0.0162296428096 | 1.0 | AKR1C2 AKR1C1 | aminoglycoside antibiotic metabolic process |
| GO:0030638 | 0.0162296428096 | 1.0 | AKR1C2 AKR1C1 | polyketide metabolic process |
| GO:0044597 | 0.0162296428096 | 1.0 | AKR1C2 AKR1C1 | daunorubicin metabolic process |
| GO:0042448 | 0.0162296428096 | 1.0 | AKR1C2 AKR1C1 | progesterone metabolic process |
| GO:0004032 | 0.0247952876258 | 1.0 | AKR1C2 AKR1C1 | alditol:NADP+ 1-oxidoreductase activity |
| GO:0016137 | 0.0473364581948 | 1.0 | AKR1C2 AKR1C1 | glycoside metabolic process |
| WP:WP4524 | 0.0499262710315 | 0.5 | AKR1C2 | The alternative pathway of fetal androgen synthesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1C2 | AKR1C1 | 1.0 | 0.949 | bioplex (AKR1C1,AKR1C2) bioplex_WMM |
Images
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Complex HuMAP2_01552 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKR1C1 | HuMAP2_00882 HuMAP2_01552 HuMAP2_03132 HuMAP2_06910 |
| AKR1C2 | HuMAP2_00697 HuMAP2_00882 HuMAP2_01552 |