hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01568
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GSK3B | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | UniProt NCBI |
| FRAT1 | Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-196299 | 0.000227925590883 | 1.0 | GSK3B FRAT1 | Beta-catenin phosphorylation cascade |
| WP:WP363 | 0.0004381556461 | 1.0 | GSK3B FRAT1 | Wnt Signaling Pathway |
| REAC:R-HSA-4641262 | 0.000729026706133 | 1.0 | GSK3B FRAT1 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| WP:WP4336 | 0.00111886173915 | 1.0 | GSK3B FRAT1 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:05224 | 0.00122335090758 | 1.0 | GSK3B FRAT1 | Breast cancer |
| KEGG:05226 | 0.00124231758831 | 1.0 | GSK3B FRAT1 | Gastric cancer |
| WP:WP4258 | 0.00139382676196 | 1.0 | GSK3B FRAT1 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:04310 | 0.00156562654612 | 1.0 | GSK3B FRAT1 | Wnt signaling pathway |
| WP:WP399 | 0.00173473868048 | 1.0 | GSK3B FRAT1 | Wnt Signaling Pathway and Pluripotency |
| KEGG:05225 | 0.00183261905189 | 1.0 | GSK3B FRAT1 | Hepatocellular carcinoma |
| WP:WP710 | 0.00199554561268 | 1.0 | GSK3B FRAT1 | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 0.00211290873217 | 1.0 | GSK3B FRAT1 | Wnt Signaling |
| WP:WP4262 | 0.00357342755251 | 1.0 | GSK3B FRAT1 | Breast cancer pathway |
| REAC:R-HSA-195253 | 0.00556574181855 | 1.0 | GSK3B FRAT1 | Degradation of beta-catenin by the destruction complex |
| MIRNA:hsa-miR-409-3p | 0.0142661167468 | 1.0 | GSK3B FRAT1 | hsa-miR-409-3p |
| KEGG:05200 | 0.0157394270613 | 1.0 | GSK3B FRAT1 | Pathways in cancer |
| REAC:R-HSA-201681 | 0.0411120784555 | 1.0 | GSK3B FRAT1 | TCF dependent signaling in response to WNT |
| CORUM:757 | 0.0499173803268 | 0.5 | GSK3B | Prune-GSK3beta complex |
| CORUM:6248 | 0.0499173803268 | 0.5 | GSK3B | FBXW7-CSF3R-GSK3B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSK3B | FRAT1 | 0.089 | 0.353 | hein_WMM hein (FRAT1) |
Images
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Complex HuMAP2_01568 has an average edge precision of 0.353 which is ranked 3888 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GSK3B | HuMAP2_01568 HuMAP2_01718 HuMAP2_04384 |
| FRAT1 | HuMAP2_01568 HuMAP2_04384 HuMAP2_04578 |