hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01570
Confidence: Medium  
ProteinsGenename | Protein Name | Links |
---|---|---|
RRN3 | RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) | UniProt   NCBI |
ZNRD1 | DNA-directed RNA polymerase I subunit RPA12 (Zinc ribbon domain-containing protein 1) | UniProt   NCBI |
TWISTNB | DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein) | UniProt   NCBI |
POLR1A | DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) | UniProt   NCBI |
POLR1D | Protein POLR1D, isoform 2 | UniProt   NCBI |
POLR1B | DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  REAC:R-HSA-73762 | 1.16219267265e-13 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | RNA Polymerase I Transcription Initiation |
  GO:0006361 | 2.99152107499e-12 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | transcription initiation from RNA polymerase I promoter |
  KEGG:03020 | 6.47647447453e-12 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | RNA polymerase |
  REAC:R-HSA-73772 | 6.73893589242e-12 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | RNA Polymerase I Promoter Escape |
  REAC:R-HSA-73854 | 2.19180564881e-11 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | RNA Polymerase I Promoter Clearance |
  REAC:R-HSA-73864 | 2.3182559747e-11 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | RNA Polymerase I Transcription |
  REAC:R-HSA-73863 | 2.73417670054e-11 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | RNA Polymerase I Transcription Termination |
  GO:0001054 | 6.3229743118e-11 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | RNA polymerase I activity |
  GO:0005736 | 6.3229743118e-11 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | RNA polymerase I complex |
  GO:0006360 | 1.48743735386e-10 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | transcription by RNA polymerase I |
  WP:WP4022 | 9.1170755239e-10 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | Pyrimidine metabolism |
  GO:0006362 | 5.82915372209e-09 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | transcription elongation from RNA polymerase I promoter |
  REAC:R-HSA-5250924 | 6.65761939932e-09 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | B-WICH complex positively regulates rRNA expression |
  GO:0006363 | 8.33923893666e-09 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | termination of RNA polymerase I transcription |
  REAC:R-HSA-5250913 | 1.47378888902e-08 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | Positive epigenetic regulation of rRNA expression |
  REAC:R-HSA-427413 | 1.54739123893e-08 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | NoRC negatively regulates rRNA expression |
  REAC:R-HSA-5250941 | 1.78599987084e-08 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | Negative epigenetic regulation of rRNA expression |
  GO:0003899 | 2.13866479475e-08 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | DNA-directed 5'-3' RNA polymerase activity |
  GO:0034062 | 3.22787683477e-08 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | 5'-3' RNA polymerase activity |
  GO:0097747 | 3.22787683477e-08 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | RNA polymerase activity |
  REAC:R-HSA-212165 | 8.24751451013e-08 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | Epigenetic regulation of gene expression |
  GO:0045815 | 2.45328000896e-07 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | positive regulation of gene expression, epigenetic |
  GO:0006352 | 3.55443487864e-07 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | DNA-templated transcription, initiation |
  GO:0006353 | 7.3546313708e-07 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | DNA-templated transcription, termination |
  GO:0055029 | 2.98904170003e-06 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | nuclear DNA-directed RNA polymerase complex |
  GO:0000428 | 3.15131232749e-06 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | DNA-directed RNA polymerase complex |
  GO:0030880 | 3.68082360643e-06 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | RNA polymerase complex |
  GO:0006354 | 4.71954327875e-06 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | DNA-templated transcription, elongation |
  GO:0016779 | 6.26212265329e-06 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | nucleotidyltransferase activity |
  CORUM:1558 | 8.39001385941e-06 | 0.333333333333 | RRN3 POLR1B | POLR1B-RRN3 complex |
  WP:WP405 | 1.59103859767e-05 | 0.5 | POLR1A POLR1D POLR1B | Eukaryotic Transcription Initiation |
  CORUM:1557 | 2.51655344529e-05 | 0.333333333333 | RRN3 POLR1B | NMI-POLR1B-RRN3 complex |
  GO:0044452 | 4.81463539559e-05 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | nucleolar part |
  REAC:R-HSA-74160 | 6.720667947e-05 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | Gene expression (Transcription) |
  GO:0061695 | 0.000213275731053 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | transferase complex, transferring phosphorus-containing groups |
  GO:0005730 | 0.000793435083069 | 1.0 | TWISTNB POLR1D POLR1A ZNRD1 POLR1B RRN3 | nucleolus |
  GO:0040029 | 0.000840887462586 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | regulation of gene expression, epigenetic |
  GO:0140098 | 0.00108021890927 | 0.833333333333 | POLR1B TWISTNB POLR1D ZNRD1 POLR1A | catalytic activity, acting on RNA |
  CORUM:5233 | 0.00230653586609 | 0.333333333333 | POLR1A POLR1B | TNF-alpha/NF-kappa B signaling complex 5 |
  CORUM:1559 | 0.0499726005494 | 0.166666666667 | RRN3 | NMI-RRN3 complex |
Edges
Protein 1 | Protein 2 | Score | Precision | Evidence |
---|---|---|---|---|
 POLR1A |  POLR1B | 1.0 | 0.949           | hein_WMM     bioplex_WMM     hein (POLR1A)     Malo     fraction     treiber_WMM     |
 POLR1A |  POLR1D | 1.0 | 0.949           | hein_WMM     bioplex_WMM     hein (POLR1A)     Malo     fraction     |
 POLR1D |  POLR1B | 1.0 | 0.949           | hein_WMM     bioplex_WMM     Malo     fraction     |
 TWISTNB |  POLR1A | 0.999 | 0.949           | hein_WMM     bioplex (TWISTNB)     bioplex_WMM     hein (POLR1A)     Malo     fraction     |
 TWISTNB |  POLR1B | 0.937 | 0.85           | hein_WMM     bioplex (TWISTNB)     bioplex_WMM     Malo     fraction     |
 TWISTNB |  POLR1D | 0.935 | 0.85           | hein_WMM     bioplex (TWISTNB)     bioplex_WMM     Malo     fraction     |
 RRN3 |  TWISTNB | 0.315 | 0.51           | hein_WMM     bioplex (TWISTNB)     bioplex_WMM     |
 POLR1A |  ZNRD1 | 0.201 | 0.451           | hein_WMM     hein (POLR1A)     |
 RRN3 |  POLR1A | 0.152 | 0.41           | hein_WMM     bioplex_WMM     hein (POLR1A)     |
 RRN3 |  POLR1D | 0.009 | 0.109           | hein_WMM     bioplex_WMM     WMM_only     |
 POLR1D |  ZNRD1 | 0.009 | 0.101           | hein_WMM     WMM_only     |
 RRN3 |  POLR1B | 0.009 | 0.089           | hein_WMM     bioplex_WMM     WMM_only     |
 POLR1B |  ZNRD1 | 0.008 | 0.088           | hein_WMM     WMM_only     |
 RRN3 |  ZNRD1 | 0.008 | 0.034           | hein_WMM     WMM_only     |
 TWISTNB |  ZNRD1 | 0.007 | 0.008           | hein_WMM     WMM_only     |
Images
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Complex HuMAP2_01570 has an average edge precision of 0.486 which is ranked 2580 out of all 6965 complexes.
Related Complexes