hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01572
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WARS | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | UniProt NCBI |
| UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | UniProt NCBI |
| UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | UniProt NCBI |
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING-type E3 ubiquitin transferase RNF25) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-983168 | 2.7101143154e-06 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | Antigen processing: Ubiquitination & Proteasome degradation |
| KEGG:04120 | 3.79677162219e-06 | 0.666666666667 | UBE2E1 UBE2D3 UBE2D4 UBE2E2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983169 | 6.62586152292e-06 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | Class I MHC mediated antigen processing & presentation |
| GO:0061631 | 1.90965027829e-05 | 0.666666666667 | UBE2E1 UBE2D3 UBE2D4 UBE2E2 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 2.69127816091e-05 | 0.666666666667 | UBE2E1 UBE2D3 UBE2D4 UBE2E2 | ubiquitin-like protein conjugating enzyme activity |
| GO:0070936 | 7.08670803224e-05 | 0.666666666667 | UBE2E1 UBE2D3 UBE2D4 UBE2E2 | protein K48-linked ubiquitination |
| REAC:R-HSA-1280218 | 0.00014564509793 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | Adaptive Immune System |
| GO:0004842 | 0.00102846969123 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | ubiquitin-protein transferase activity |
| GO:0019787 | 0.00152662559807 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | ubiquitin-like protein transferase activity |
| WP:WP3613 | 0.00180854165103 | 0.333333333333 | UBE2E1 WARS | Photodynamic therapy-induced unfolded protein response |
| GO:0070979 | 0.00529364410104 | 0.5 | UBE2E2 UBE2D4 UBE2D3 | protein K11-linked ubiquitination |
| KEGG:05131 | 0.0124835568261 | 0.333333333333 | UBE2D3 UBE2D4 | Shigellosis |
| REAC:R-HSA-168256 | 0.0201098402149 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | Immune System |
| GO:0016567 | 0.0232452530705 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | protein ubiquitination |
| REAC:R-HSA-8866654 | 0.0338154872995 | 0.333333333333 | UBE2E1 UBE2D3 | E3 ubiquitin ligases ubiquitinate target proteins |
| GO:0042296 | 0.0405595771497 | 0.333333333333 | UBE2E1 UBE2E2 | ISG15 transferase activity |
| GO:0032446 | 0.0424115510531 | 0.833333333333 | UBE2E1 UBE2D3 UBE2D4 RNF25 UBE2E2 | protein modification by small protein conjugation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBE2D4 | RNF25 | 1.0 | 0.949 | bioplex (RNF25) bioplex_WMM |
| RNF25 | UBE2E1 | 0.226 | 0.467 | bioplex (RNF25) bioplex_WMM |
| RNF25 | UBE2E2 | 0.171 | 0.429 | bioplex (RNF25,UBE2E2) bioplex_WMM |
| RNF25 | UBE2D3 | 0.058 | 0.328 | bioplex (RNF25) bioplex_WMM |
| UBE2E2 | WARS | 0.032 | 0.244 | fraction |
| UBE2E2 | UBE2E1 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| UBE2D4 | UBE2E2 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| UBE2D4 | UBE2E1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| UBE2D4 | UBE2D3 | 0.008 | 0.009 | bioplex_WMM WMM_only |
| UBE2D3 | UBE2E2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| UBE2D3 | UBE2E1 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
| UBE2D3 | WARS | 0.006 | 0.006 | bioplex_WMM gupta_WMM WMM_only |
| WARS | UBE2E1 | 0.0 | 0.005 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_01572 has an average edge precision of 0.207 which is ranked 6081 out of all 6965 complexes.
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