hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01592
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM1A | Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) | UniProt NCBI |
| RCOR1 | REST corepressor 1 (Protein CoREST) | UniProt NCBI |
| HMG20A | High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) | UniProt NCBI |
| RCOR3 | REST corepressor 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:626 | 3.2421610347e-11 | 1.0 | HMG20A RCOR3 KDM1A RCOR1 | LSD1 complex |
| CORUM:642 | 4.58833350325e-07 | 0.75 | RCOR3 KDM1A RCOR1 | CtBP complex |
| CORUM:624 | 5.02777038712e-06 | 0.5 | KDM1A RCOR1 | LSD1-CoREST complex |
| CORUM:648 | 1.50819606993e-05 | 0.5 | KDM1A RCOR1 | HDAC1-associated core complex cI |
| CORUM:636 | 7.53895486054e-05 | 0.5 | KDM1A RCOR1 | BHC complex |
| CORUM:620 | 0.000105535916717 | 0.5 | KDM1A RCOR1 | CoREST-HDAC complex |
| CORUM:871 | 0.000105535916717 | 0.5 | KDM1A RCOR1 | BRAF53-BRCA2 complex |
| CORUM:643 | 0.000180886312261 | 0.5 | KDM1A RCOR1 | CtBP core complex |
| CORUM:646 | 0.000180886312261 | 0.5 | KDM1A RCOR1 | HDAC1-associated protein complex |
| CORUM:1492 | 0.000226087640536 | 0.5 | KDM1A RCOR1 | BHC110 complex |
| CORUM:633 | 0.000276304589937 | 0.5 | KDM1A RCOR1 | anti-BHC110 complex |
| CORUM:632 | 0.000682858782186 | 0.5 | KDM1A RCOR1 | Anti-HDAC2 complex |
| HPA:013010_13 | 0.00093798189622 | 0.75 | HMG20A KDM1A RCOR1 | endometrium 1; cells in endometrial stroma[Supported,High] |
| HPA:013010_03 | 0.00210273983896 | 0.75 | HMG20A KDM1A RCOR1 | endometrium 1; cells in endometrial stroma[Uncertain,High] |
| HPA:043020_13 | 0.00298968268698 | 0.75 | HMG20A KDM1A RCOR1 | skin 1; fibroblasts[Supported,High] |
| HPA:021010_13 | 0.00400850778369 | 0.75 | HMG20A KDM1A RCOR1 | heart muscle; myocytes[Supported,High] |
| HPA:027020_13 | 0.00473735436563 | 0.75 | HMG20A KDM1A RCOR1 | lung; pneumocytes[Supported,High] |
| HPA:039010_13 | 0.0101046758484 | 0.75 | HMG20A KDM1A RCOR1 | salivary gland; glandular cells[Supported,High] |
| HPA:027020_03 | 0.0106711364101 | 0.75 | HMG20A KDM1A RCOR1 | lung; pneumocytes[Uncertain,High] |
| HPA:004010_12 | 0.0117781632296 | 0.75 | HMG20A KDM1A RCOR1 | breast; adipocytes[Supported,Medium] |
| HPA:043020_03 | 0.0119549395508 | 0.75 | HMG20A KDM1A RCOR1 | skin 1; fibroblasts[Uncertain,High] |
| HPA:003010_13 | 0.0120439825181 | 0.75 | HMG20A KDM1A RCOR1 | bone marrow; hematopoietic cells[Supported,High] |
| REAC:R-HSA-8943724 | 0.0159697215039 | 0.5 | KDM1A RCOR1 | Regulation of PTEN gene transcription |
| HPA:001040_13 | 0.0188187097484 | 0.75 | HMG20A KDM1A RCOR1 | adrenal gland; glandular cells[Supported,High] |
| HPA:022010_12 | 0.0205475883704 | 0.75 | HMG20A KDM1A RCOR1 | hippocampus; glial cells[Supported,Medium] |
| HPA:021010_03 | 0.0218446946143 | 0.75 | HMG20A KDM1A RCOR1 | heart muscle; myocytes[Uncertain,High] |
| HPA:035020_13 | 0.025175887812 | 0.75 | HMG20A KDM1A RCOR1 | placenta; trophoblastic cells[Supported,High] |
| HPA:006010_12 | 0.0254677066879 | 0.75 | HMG20A KDM1A RCOR1 | caudate; glial cells[Supported,Medium] |
| HPA:013010_12 | 0.02561445023 | 0.75 | HMG20A KDM1A RCOR1 | endometrium 1; cells in endometrial stroma[Supported,Medium] |
| HPA:031020_12 | 0.0259096106078 | 0.75 | HMG20A KDM1A RCOR1 | ovary; ovarian stroma cells[Supported,Medium] |
| HPA:048030_12 | 0.026506652998 | 0.75 | HMG20A KDM1A RCOR1 | soft tissue 2; fibroblasts[Supported,Medium] |
| HPA:047030_12 | 0.0281952055319 | 0.75 | HMG20A KDM1A RCOR1 | soft tissue 1; fibroblasts[Supported,Medium] |
| HPA:050020_12 | 0.0296284087039 | 0.75 | HMG20A KDM1A RCOR1 | spleen; cells in white pulp[Supported,Medium] |
| HPA:019010_13 | 0.0338599256539 | 0.75 | HMG20A KDM1A RCOR1 | gallbladder; glandular cells[Supported,High] |
| HPA:008020_12 | 0.0340369984952 | 0.75 | HMG20A KDM1A RCOR1 | cerebral cortex; glial cells[Supported,Medium] |
| HPA:004010_11 | 0.0342146813303 | 0.75 | HMG20A KDM1A RCOR1 | breast; adipocytes[Supported,Low] |
| HPA:007020_12 | 0.0365805245307 | 0.75 | HMG20A KDM1A RCOR1 | cerebellum; cells in granular layer[Supported,Medium] |
| HPA:047010_11 | 0.0382800635721 | 0.75 | HMG20A KDM1A RCOR1 | soft tissue 1; adipocytes[Supported,Low] |
| HPA:024010_12 | 0.038664676769 | 0.75 | HMG20A KDM1A RCOR1 | kidney; cells in glomeruli[Supported,Medium] |
| HPA:050010_12 | 0.0410259794916 | 0.75 | HMG20A KDM1A RCOR1 | spleen; cells in red pulp[Supported,Medium] |
| HPA:039010_03 | 0.0416307958449 | 0.75 | HMG20A KDM1A RCOR1 | salivary gland; glandular cells[Uncertain,High] |
| HPA:027020_12 | 0.0418336999884 | 0.75 | HMG20A KDM1A RCOR1 | lung; pneumocytes[Supported,Medium] |
| REAC:R-HSA-3214815 | 0.042667909674 | 0.5 | KDM1A RCOR1 | HDACs deacetylate histones |
| HPA:041010_12 | 0.0438987109299 | 0.75 | HMG20A KDM1A RCOR1 | skeletal muscle; myocytes[Supported,Medium] |
| HPA:003010_03 | 0.044531057523 | 0.75 | HMG20A KDM1A RCOR1 | bone marrow; hematopoietic cells[Uncertain,High] |
| HPA:007030_12 | 0.0447431662559 | 0.75 | HMG20A KDM1A RCOR1 | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:043020_12 | 0.0458137035926 | 0.75 | HMG20A KDM1A RCOR1 | skin 1; fibroblasts[Supported,Medium] |
| HPA:048010_11 | 0.0458137035926 | 0.75 | HMG20A KDM1A RCOR1 | soft tissue 2; adipocytes[Supported,Low] |
| HPA:028010_12 | 0.0466821853682 | 0.75 | HMG20A KDM1A RCOR1 | lymph node; germinal center cells[Supported,Medium] |
| CORUM:2160 | 0.0499140284799 | 0.25 | KDM1A | AOF2-AR complex |
| CORUM:1233 | 0.0499140284799 | 0.25 | RCOR1 | CoREST-HDAC2 complex |
| CORUM:6477 | 0.0499140284799 | 0.25 | KDM1A | ZEB2-KDM1A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KDM1A | RCOR1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| KDM1A | RCOR3 | 0.997 | 0.93 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| RCOR1 | HMG20A | 0.996 | 0.926 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt youn_WMM hein (HMG20A) boldt_WMM |
| KDM1A | HMG20A | 0.984 | 0.899 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt youn_WMM hein (HMG20A) boldt_WMM |
| HMG20A | RCOR3 | 0.924 | 0.843 | hein_WMM bioplex (HMG20A) bioplex_WMM youn_WMM hein (HMG20A) |
| RCOR1 | RCOR3 | 0.089 | 0.356 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_01592 has an average edge precision of 0.817 which is ranked 892 out of all 6965 complexes.
Related Complexes