hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01596
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BIRC7 | Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] | UniProt NCBI |
| DUSP22 | Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | UniProt NCBI |
| LRRN2 | Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) | UniProt NCBI |
| BIRC2 | Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) | UniProt NCBI |
| DIABLO | Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) | UniProt NCBI |
| ZNF669 | Zinc finger protein 669 | UniProt NCBI |
| GNA14 | Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 1.34541590884e-05 | 0.428571428571 | XIAP BIRC2 BIRC7 | Apoptosis - multiple species |
| GO:1990001 | 3.17736949706e-05 | 0.428571428571 | XIAP BIRC2 BIRC7 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0097340 | 0.000111163123615 | 0.428571428571 | XIAP BIRC2 BIRC7 | inhibition of cysteine-type endopeptidase activity |
| GO:0097341 | 0.000111163123615 | 0.428571428571 | XIAP BIRC2 BIRC7 | zymogen inhibition |
| WP:WP1772 | 0.00028400752819 | 0.428571428571 | XIAP BIRC2 BIRC7 | Apoptosis Modulation and Signaling |
| KEGG:05222 | 0.000410972913564 | 0.428571428571 | XIAP BIRC2 BIRC7 | Small cell lung cancer |
| KEGG:05145 | 0.000438494812888 | 0.428571428571 | XIAP BIRC2 BIRC7 | Toxoplasmosis |
| KEGG:04120 | 0.00116183627381 | 0.428571428571 | XIAP BIRC2 BIRC7 | Ubiquitin mediated proteolysis |
| GO:1903318 | 0.00215539204286 | 0.428571428571 | XIAP BIRC2 BIRC7 | negative regulation of protein maturation |
| GO:0010955 | 0.00215539204286 | 0.428571428571 | XIAP BIRC2 BIRC7 | negative regulation of protein processing |
| GO:0043027 | 0.00307019549622 | 0.428571428571 | XIAP BIRC2 BIRC7 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| REAC:R-HSA-5675482 | 0.00378769086114 | 0.285714285714 | XIAP BIRC2 | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.00482714346521 | 0.285714285714 | XIAP BIRC2 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5218859 | 0.00482714346521 | 0.285714285714 | XIAP BIRC2 | Regulated Necrosis |
| REAC:R-HSA-5357956 | 0.0127777645063 | 0.285714285714 | XIAP BIRC2 | TNFR1-induced NFkappaB signaling pathway |
| REAC:R-HSA-5357905 | 0.0136873957341 | 0.285714285714 | XIAP BIRC2 | Regulation of TNFR1 signaling |
| GO:0043028 | 0.0156741996846 | 0.428571428571 | XIAP BIRC2 BIRC7 | cysteine-type endopeptidase regulator activity involved in apoptotic process |
| GO:0070613 | 0.02067047809 | 0.428571428571 | XIAP BIRC2 BIRC7 | regulation of protein processing |
| REAC:R-HSA-75893 | 0.024487996647 | 0.285714285714 | XIAP BIRC2 | TNF signaling |
| GO:1903317 | 0.0245293846287 | 0.428571428571 | XIAP BIRC2 BIRC7 | regulation of protein maturation |
| KEGG:01524 | 0.0249705175143 | 0.285714285714 | XIAP BIRC2 | Platinum drug resistance |
| WP:WP254 | 0.0260504484155 | 0.285714285714 | XIAP BIRC2 | Apoptosis |
| KEGG:04064 | 0.030052232514 | 0.285714285714 | XIAP BIRC2 | NF-kappa B signaling pathway |
| GO:0004869 | 0.0311716432999 | 0.428571428571 | XIAP BIRC2 BIRC7 | cysteine-type endopeptidase inhibitor activity |
| WP:WP4658 | 0.0440421557794 | 0.285714285714 | BIRC7 BIRC2 | Small cell lung cancer |
| HP:0011898 | 0.0499089185913 | 0.285714285714 | XIAP GNA14 | Abnormality of circulating fibrinogen |
| HP:0011900 | 0.0499089185913 | 0.285714285714 | XIAP GNA14 | Hypofibrinogenemia |
| CORUM:6292 | 0.0499886427319 | 0.142857142857 | XIAP | HAX-1-XIAP complex |
| CORUM:3177 | 0.0499886427319 | 0.142857142857 | GNA14 | GNA14-p115RhoGEF complex |
| CORUM:5529 | 0.0499886427319 | 0.142857142857 | BIRC2 | TRAF2-cIAP1/BIRC2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XIAP | DIABLO | 0.528 | 0.633 | bioplex (DIABLO) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BIRC7 | DIABLO | 0.181 | 0.436 | bioplex (BIRC7) bioplex_WMM |
| DUSP22 | DIABLO | 0.151 | 0.411 | bioplex (DIABLO) bioplex_WMM |
| DIABLO | BIRC2 | 0.05 | 0.294 | bioplex (BIRC2,DIABLO) bioplex_WMM |
| XIAP | LRRN2 | 0.025 | 0.218 | bioplex (LRRN2) bioplex_WMM |
| DUSP22 | GNA14 | 0.024 | 0.214 | bioplex (DUSP22) bioplex_WMM |
| LRRN2 | ZNF669 | 0.023 | 0.205 | bioplex (LRRN2) bioplex_WMM |
| LRRN2 | BIRC2 | 0.015 | 0.148 | bioplex (LRRN2) bioplex_WMM |
| DUSP22 | XIAP | 0.008 | 0.014 | bioplex_WMM WMM_only |
| DUSP22 | BIRC2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| XIAP | ZNF669 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| ZNF669 | BIRC2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| XIAP | BIRC2 | 0.006 | 0.006 | bioplex (BIRC2) bioplex_WMM |
| XIAP | BIRC7 | 0.0 | 0.003 | bioplex (BIRC7) bioplex_WMM |
| BIRC7 | BIRC2 | 0.0 | 0.0 | bioplex (BIRC7) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_01596 has an average edge precision of 0.173 which is ranked 6495 out of all 6965 complexes.
Related Complexes