hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01597
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SHC2 | SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) | UniProt NCBI |
| SHC1 | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | UniProt NCBI |
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | UniProt NCBI |
| RASAL2 | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4223 | 0.000136289943844 | 0.75 | SHC1 SHC2 RASAL2 | Ras Signaling |
| KEGG:04014 | 0.00027234077557 | 0.75 | SHC1 SHC2 RASAL2 | Ras signaling pathway |
| REAC:R-HSA-167044 | 0.00136571756437 | 0.5 | SHC1 SHC2 | Signalling to RAS |
| REAC:R-HSA-5673001 | 0.00160248259072 | 0.75 | SHC1 SHC2 RASAL2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.00172984464116 | 0.75 | SHC1 SHC2 RASAL2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.00206255463692 | 0.75 | SHC1 SHC2 RASAL2 | FLT3 Signaling |
| REAC:R-HSA-449836 | 0.00256874155841 | 0.75 | SHC1 SHC2 RASAL2 | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.00288669011569 | 0.75 | SHC1 SHC2 RASAL2 | MAPK family signaling cascades |
| KEGG:04917 | 0.00376859643257 | 0.5 | SHC1 SHC2 | Prolactin signaling pathway |
| REAC:R-HSA-187687 | 0.00407268683926 | 0.5 | SHC1 SHC2 | Signalling to ERKs |
| KEGG:05214 | 0.00453740909542 | 0.5 | SHC1 SHC2 | Glioma |
| KEGG:05100 | 0.00523220354961 | 0.5 | SHC1 SHC2 | Bacterial invasion of epithelial cells |
| KEGG:05220 | 0.00537705972469 | 0.5 | SHC1 SHC2 | Chronic myeloid leukemia |
| KEGG:01521 | 0.00537705972469 | 0.5 | SHC1 SHC2 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP673 | 0.00595343133727 | 0.5 | SHC1 SHC2 | ErbB Signaling Pathway |
| KEGG:04012 | 0.00613079763587 | 0.5 | SHC1 SHC2 | ErbB signaling pathway |
| KEGG:01522 | 0.00796156937098 | 0.5 | SHC1 SHC2 | Endocrine resistance |
| KEGG:04650 | 0.00963554317862 | 0.5 | SHC1 SHC2 | Natural killer cell mediated cytotoxicity |
| KEGG:04722 | 0.0112562119133 | 0.5 | SHC1 SHC2 | Neurotrophin signaling pathway |
| WP:WP3929 | 0.012672821387 | 0.5 | SHC1 SHC2 | Chemokine signaling pathway |
| WP:WP3915 | 0.012672821387 | 0.5 | SHC1 SHC2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04926 | 0.0141554312811 | 0.5 | SHC1 SHC2 | Relaxin signaling pathway |
| KEGG:04915 | 0.0146305942314 | 0.5 | SHC1 SHC2 | Estrogen signaling pathway |
| WP:WP2380 | 0.0152387809455 | 0.5 | SHC1 SHC2 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| KEGG:04910 | 0.0153578793248 | 0.5 | SHC1 SHC2 | Insulin signaling pathway |
| KEGG:04072 | 0.0156041830743 | 0.5 | SHC1 SHC2 | Phospholipase D signaling pathway |
| WP:WP4262 | 0.0159167413674 | 0.5 | SHC1 SHC2 | Breast cancer pathway |
| KEGG:05224 | 0.016608760826 | 0.5 | SHC1 SHC2 | Breast cancer |
| KEGG:04062 | 0.016608760826 | 0.5 | SHC1 SHC2 | Chemokine signaling pathway |
| KEGG:05226 | 0.0168647432957 | 0.5 | SHC1 SHC2 | Gastric cancer |
| WP:WP481 | 0.0195247658454 | 0.5 | SHC1 SHC2 | Insulin Signaling |
| KEGG:05225 | 0.0248155779574 | 0.5 | SHC1 SHC2 | Hepatocellular carcinoma |
| REAC:R-HSA-187037 | 0.0262582706021 | 0.5 | SHC1 SHC2 | Signaling by NTRK1 (TRKA) |
| KEGG:05034 | 0.027038855262 | 0.5 | SHC1 SHC2 | Alcoholism |
| REAC:R-HSA-449147 | 0.0289233648573 | 0.75 | SHC1 SHC2 RASAL2 | Signaling by Interleukins |
| WP:WP306 | 0.0290430519819 | 0.5 | SHC1 SHC2 | Focal Adhesion |
| KEGG:04510 | 0.0350038155474 | 0.5 | SHC1 SHC2 | Focal adhesion |
| WP:WP3888 | 0.0393304030404 | 0.5 | SHC1 SHC2 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-166520 | 0.0408500448467 | 0.5 | SHC1 SHC2 | Signaling by NTRKs |
| CORUM:2895 | 0.0499140284799 | 0.25 | SHC1 | SHC-GRB2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SHC2 | SHC1 | 1.0 | 0.949 | bioplex (SHC1) bioplex_WMM |
| SHC1 | RFFL | 0.527 | 0.634 | bioplex (RFFL) |
| RASAL2 | SHC1 | 0.027 | 0.228 | bioplex (SHC1) bioplex_WMM youn_WMM |
| RASAL2 | SHC2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01597 has an average edge precision of 0.475 which is ranked 2660 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SHC2 | HuMAP2_01597 HuMAP2_04831 HuMAP2_05704 |
| SHC1 | HuMAP2_01597 HuMAP2_04831 HuMAP2_05704 |
| RFFL | HuMAP2_01597 HuMAP2_04831 |
| RASAL2 | HuMAP2_00673 HuMAP2_00796 HuMAP2_01597 |