hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01602
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EXOC4 | Exocyst complex component 4 (Exocyst complex component Sec8) | UniProt NCBI |
| EXOC6B | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | UniProt NCBI |
| EXOC6 | Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) | UniProt NCBI |
| EXOC5 | Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) | UniProt NCBI |
| EXOC7 | Exocyst complex component 7 (Exocyst complex component Exo70) | UniProt NCBI |
| EXOC8 | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6167 | 3.41442383848e-15 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Exocyst complex |
| CORUM:89 | 3.41442383848e-15 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Exocyst Sec6/8 complex |
| REAC:R-HSA-5620916 | 1.87241503761e-12 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | VxPx cargo-targeting to cilium |
| REAC:R-HSA-264876 | 6.84234945834e-12 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Insulin processing |
| GO:0000145 | 6.3229743118e-11 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | exocyst |
| REAC:R-HSA-5620920 | 2.46617285137e-10 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Cargo trafficking to the periciliary membrane |
| WP:WP4352 | 3.20310778999e-10 | 1.0 | EXOC7 EXOC8 EXOC6B EXOC6 EXOC4 EXOC5 | Ciliary landscape |
| REAC:R-HSA-1445148 | 1.67395276865e-09 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-2980736 | 1.80462896099e-09 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Peptide hormone metabolism |
| CORUM:6169 | 2.25356268047e-09 | 0.5 | EXOC7 EXOC5 EXOC6 | Exocyst EXOC5-EXOC6-EXOC7 subcomplex |
| GO:0006893 | 1.03878083327e-07 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | Golgi to plasma membrane transport |
| GO:0099023 | 1.87214020073e-07 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | vesicle tethering complex |
| REAC:R-HSA-5617833 | 3.20449539048e-07 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Cilium Assembly |
| GO:0098876 | 8.45002432374e-07 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | vesicle-mediated transport to the plasma membrane |
| REAC:R-HSA-1852241 | 2.15632898754e-06 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Organelle biogenesis and maintenance |
| GO:0006892 | 2.54188840198e-06 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | post-Golgi vesicle-mediated transport |
| CORUM:6168 | 8.39001385941e-06 | 0.333333333333 | EXOC5 EXOC6 | Exocyst EXOC5-EXOC6 subcomplex |
| GO:0044448 | 1.82257466648e-05 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | cell cortex part |
| REAC:R-HSA-199991 | 8.45689503243e-05 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000110463892332 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Vesicle-mediated transport |
| GO:0005938 | 0.0001171825963 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | cell cortex |
| GO:0017160 | 0.000660060925697 | 0.5 | EXOC4 EXOC8 EXOC5 | Ral GTPase binding |
| GO:0099568 | 0.000915395559194 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | cytoplasmic region |
| GO:0048193 | 0.00154995173844 | 0.833333333333 | EXOC6B EXOC4 EXOC6 EXOC8 EXOC5 | Golgi vesicle transport |
| REAC:R-HSA-392499 | 0.0232605972232 | 0.833333333333 | EXOC7 EXOC4 EXOC6 EXOC8 EXOC5 | Metabolism of proteins |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EXOC7 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC6,EXOC7) Malo fraction boldt_WMM |
| EXOC8 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6,EXOC8) bioplex_WMM boldt (EXOC6,EXOC8) Malo fraction boldt_WMM |
| EXOC8 | EXOC7 | 1.0 | 0.949 | bioplex (EXOC8) bioplex_WMM boldt (EXOC8) Malo fraction boldt_WMM |
| EXOC5 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC5,EXOC6) Malo fraction boldt_WMM |
| EXOC8 | EXOC6B | 0.998 | 0.944 | bioplex (EXOC8) bioplex_WMM boldt (EXOC6B,EXOC8) Malo fraction boldt_WMM |
| EXOC7 | EXOC6B | 0.992 | 0.911 | bioplex_WMM boldt (EXOC6B,EXOC7) Malo fraction boldt_WMM |
| EXOC5 | EXOC7 | 0.979 | 0.895 | bioplex_WMM boldt (EXOC5,EXOC7) Malo fraction boldt_WMM |
| EXOC4 | EXOC7 | 0.959 | 0.865 | bioplex_WMM boldt (EXOC4,EXOC7) fraction boldt_WMM |
| EXOC4 | EXOC6 | 0.939 | 0.851 | bioplex (EXOC6) bioplex_WMM boldt (EXOC4,EXOC6) youn_WMM fraction boldt_WMM |
| EXOC8 | EXOC5 | 0.708 | 0.729 | bioplex (EXOC8) bioplex_WMM boldt (EXOC5,EXOC8) Malo fraction boldt_WMM |
| EXOC5 | EXOC6B | 0.653 | 0.69 | bioplex_WMM boldt (EXOC5,EXOC6B) Malo fraction boldt_WMM |
| EXOC4 | EXOC5 | 0.385 | 0.551 | bioplex_WMM boldt (EXOC4,EXOC5) youn_WMM gupta_WMM fraction boldt_WMM |
| EXOC8 | EXOC4 | 0.256 | 0.479 | bioplex (EXOC8) bioplex_WMM boldt (EXOC4,EXOC8) fraction boldt_WMM |
| EXOC4 | EXOC6B | 0.166 | 0.422 | bioplex_WMM boldt (EXOC4,EXOC6B) fraction boldt_WMM |
| EXOC6B | EXOC6 | 0.017 | 0.173 | bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_01602 has an average edge precision of 0.754 which is ranked 1125 out of all 6965 complexes.
Related Complexes