hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01618
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAMA5 | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) | UniProt NCBI |
| LAMC1 | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | UniProt NCBI |
| LAMB2 | Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) | UniProt NCBI |
| EEA1 | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | UniProt NCBI |
| LAMB1 | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | UniProt NCBI |
| AGA | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | UniProt NCBI |
| LAMB4 | Laminin subunit beta-4 (Laminin beta-1-related protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0043256 | 9.63047224659e-12 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | laminin complex |
| KEGG:04512 | 3.77582331482e-09 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | ECM-receptor interaction |
| WP:WP453 | 5.42156399646e-09 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Inflammatory Response Pathway |
| KEGG:05146 | 5.862099722e-09 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | Amoebiasis |
| KEGG:05222 | 8.7817399035e-09 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | Small cell lung cancer |
| KEGG:05145 | 9.79988532746e-09 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | Toxoplasmosis |
| WP:WP4658 | 1.0497206895e-08 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | Small cell lung cancer |
| CORUM:2319 | 3.38018031602e-08 | 0.428571428571 | LAMA5 LAMC1 LAMB2 | ITGA6-ITGB4-Laminin10/12 complex |
| CORUM:2318 | 3.38018031602e-08 | 0.428571428571 | LAMA5 LAMC1 LAMB1 | ITGA6-ITGB4-Laminin10/12 complex |
| WP:WP244 | 3.69960241137e-08 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Alpha 6 Beta 4 signaling pathway |
| REAC:R-HSA-8874081 | 5.82439048525e-08 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | MET activates PTK2 signaling |
| GO:0044420 | 7.47192024193e-08 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | extracellular matrix component |
| REAC:R-HSA-3000157 | 7.7932067567e-08 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Laminin interactions |
| REAC:R-HSA-8875878 | 1.87601191777e-07 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | MET promotes cell motility |
| GO:0005604 | 2.626450958e-07 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | basement membrane |
| KEGG:04510 | 3.36535846807e-07 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | Focal adhesion |
| REAC:R-HSA-3000171 | 1.11840907036e-06 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 2.03763943066e-06 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | ECM proteoglycans |
| WP:WP4172 | 2.77765299142e-06 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-6806834 | 3.07375784275e-06 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Signaling by MET |
| GO:0043260 | 3.17865016081e-06 | 0.428571428571 | LAMA5 LAMC1 LAMB2 | laminin-11 complex |
| GO:0043259 | 3.17865016081e-06 | 0.428571428571 | LAMA5 LAMC1 LAMB1 | laminin-10 complex |
| KEGG:04151 | 3.41566047287e-06 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | PI3K-Akt signaling pathway |
| GO:0034446 | 4.10096921113e-06 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | substrate adhesion-dependent cell spreading |
| KEGG:05165 | 4.15537865589e-06 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | Human papillomavirus infection |
| KEGG:05200 | 3.03475025714e-05 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | Pathways in cancer |
| WP:WP306 | 4.44410602861e-05 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Focal Adhesion |
| GO:0005201 | 4.48890323453e-05 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | extracellular matrix structural constituent |
| WP:WP3932 | 0.000152413265395 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP2806 | 0.000273544011369 | 0.428571428571 | LAMA5 LAMC1 LAMB1 | Human Complement System |
| GO:0070831 | 0.000380900357231 | 0.428571428571 | LAMB4 LAMB2 LAMB1 | basement membrane assembly |
| REAC:R-HSA-1474244 | 0.000566510317851 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Extracellular matrix organization |
| GO:0031589 | 0.000861094013149 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | cell-substrate adhesion |
| REAC:R-HSA-8957275 | 0.00118651715165 | 0.428571428571 | LAMB1 LAMC1 LAMB2 | Post-translational protein phosphorylation |
| GO:0030198 | 0.00138873543564 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | extracellular matrix organization |
| GO:0071711 | 0.00144279242783 | 0.428571428571 | LAMB4 LAMB2 LAMB1 | basement membrane organization |
| REAC:R-HSA-381426 | 0.00184251586032 | 0.428571428571 | LAMB1 LAMC1 LAMB2 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| WP:WP2911 | 0.00210605462929 | 0.285714285714 | LAMC1 LAMB2 | miRNA targets in ECM and membrane receptors |
| GO:0043062 | 0.00289568484403 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | extracellular structure organization |
| REAC:R-HSA-9006934 | 0.00301271618311 | 0.571428571429 | LAMB1 LAMA5 LAMC1 LAMB2 | Signaling by Receptor Tyrosine Kinases |
| GO:0062023 | 0.00342473107509 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | collagen-containing extracellular matrix |
| REAC:R-HSA-1474228 | 0.003538663087 | 0.428571428571 | LAMA5 LAMC1 LAMB1 | Degradation of the extracellular matrix |
| GO:0031012 | 0.0085570636291 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | extracellular matrix |
| WP:WP2572 | 0.0194028583033 | 0.285714285714 | LAMB2 LAMA5 | Primary Focal Segmental Glomerulosclerosis FSGS |
| GO:0000904 | 0.0257043347096 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | cell morphogenesis involved in differentiation |
| GO:0005606 | 0.0283955176165 | 0.285714285714 | LAMC1 LAMB1 | laminin-1 complex |
| GO:0005198 | 0.0338967640238 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | structural molecule activity |
| GO:0009887 | 0.0415114195377 | 0.714285714286 | LAMB1 LAMA5 LAMB4 LAMC1 LAMB2 | animal organ morphogenesis |
| CORUM:2572 | 0.0499886427319 | 0.142857142857 | EEA1 | RAB5-EEA1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAMC1 | LAMB2 | 0.354 | 0.539 | bioplex_WMM fraction |
| LAMC1 | LAMA5 | 0.288 | 0.489 | bioplex_WMM Guru fraction |
| LAMC1 | LAMB1 | 0.096 | 0.358 | bioplex_WMM fraction |
| LAMB2 | LAMA5 | 0.09 | 0.355 | bioplex_WMM fraction |
| LAMC1 | EEA1 | 0.048 | 0.294 | bioplex_WMM fraction |
| LAMB4 | LAMA5 | 0.027 | 0.229 | fraction |
| LAMB1 | EEA1 | 0.022 | 0.208 | fraction |
| LAMA5 | AGA | 0.022 | 0.205 | fraction |
| AGA | LAMB1 | 0.019 | 0.182 | bioplex_WMM fraction |
| LAMB2 | EEA1 | 0.017 | 0.175 | fraction |
| LAMA5 | LAMB1 | 0.016 | 0.157 | bioplex_WMM fraction |
| LAMB2 | LAMB1 | 0.006 | 0.006 | bioplex_WMM WMM_only |
| LAMC1 | AGA | 0.004 | 0.012 | bioplex (AGA) bioplex_WMM |
| LAMB2 | AGA | 0.0 | 0.014 | bioplex (AGA) fraction |
Images
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Complex HuMAP2_01618 has an average edge precision of 0.23 which is ranked 5693 out of all 6965 complexes.
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