hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01634
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DENND5A | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | UniProt NCBI |
| SBF1 | Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1) | UniProt NCBI |
| RAB6A | Ras-related protein Rab-6A (Rab-6) | UniProt NCBI |
| RAB6C | Ras-related protein Rab-6C (Rab6-like protein WTH3) | UniProt NCBI |
| RAB6B | Ras-related protein Rab-6B | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8876198 | 7.36239529367e-07 | 0.8 | RAB6A RAB6B SBF1 DENND5A | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 2.59920773791e-06 | 0.8 | RAB6A RAB6B SBF1 DENND5A | Rab regulation of trafficking |
| GO:0042147 | 0.000202099795148 | 0.8 | RAB6A RAB6C RAB6B DENND5A | retrograde transport, endosome to Golgi |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | RAB6A RAB6B SBF1 DENND5A | Membrane Trafficking |
| GO:0016482 | 0.00202202063273 | 0.8 | RAB6A RAB6C RAB6B DENND5A | cytosolic transport |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | RAB6A RAB6B SBF1 DENND5A | Vesicle-mediated transport |
| GO:0006891 | 0.00367721278555 | 0.6 | RAB6A RAB6C RAB6B | intra-Golgi vesicle-mediated transport |
| GO:0016197 | 0.00780704088192 | 0.8 | RAB6A RAB6C RAB6B DENND5A | endosomal transport |
| REAC:R-HSA-8854214 | 0.012121451174 | 0.4 | RAB6A RAB6B | TBC/RABGAPs |
| REAC:R-HSA-6811440 | 0.0145030354259 | 0.4 | RAB6A RAB6B | Retrograde transport at the Trans-Golgi-Network |
| REAC:R-HSA-6811436 | 0.0164283536306 | 0.4 | RAB6A RAB6B | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-8873719 | 0.0253191001807 | 0.4 | RAB6A RAB6B | RAB geranylgeranylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB6A | RAB6B | 0.743 | 0.739 | bioplex (RAB6B) bioplex_WMM treiber_WMM |
| RAB6B | RAB6C | 0.41 | 0.569 | bioplex (RAB6B) bioplex_WMM |
| RAB6B | DENND5A | 0.309 | 0.503 | bioplex (RAB6B) bioplex_WMM |
| RAB6B | SBF1 | 0.05 | 0.295 | bioplex (RAB6B) bioplex_WMM |
| DENND5A | RAB6C | 0.009 | 0.095 | bioplex_WMM WMM_only |
| RAB6A | DENND5A | 0.008 | 0.088 | bioplex_WMM gupta_WMM WMM_only |
| RAB6A | RAB6C | 0.008 | 0.089 | bioplex_WMM WMM_only |
| SBF1 | DENND5A | 0.008 | 0.041 | bioplex_WMM WMM_only |
| SBF1 | RAB6C | 0.008 | 0.041 | bioplex_WMM WMM_only |
| RAB6A | SBF1 | 0.007 | 0.006 | bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_01634 has an average edge precision of 0.247 which is ranked 5426 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DENND5A | HuMAP2_01634 HuMAP2_04163 |
| SBF1 | HuMAP2_01634 HuMAP2_02156 HuMAP2_04976 |
| RAB6A | HuMAP2_00116 HuMAP2_01634 |
| RAB6C | HuMAP2_01634 HuMAP2_04163 |
| RAB6B | HuMAP2_00116 HuMAP2_01634 HuMAP2_03796 HuMAP2_04163 |