hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01636
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FKBP2 | Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) | UniProt NCBI |
| TRPC5 | Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5) | UniProt NCBI |
| AASS | Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)] | UniProt NCBI |
| NUDT13 | Nucleoside diphosphate-linked moiety X motif 13 (Nudix motif 13) (EC 3.-.-.-) (Protein KiSS-16) | UniProt NCBI |
| HK3 | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) | UniProt NCBI |
| HKDC1 | Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1) | UniProt NCBI |
| HK1 | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) | UniProt NCBI |
| HK2 | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00524 | 8.20828027052e-12 | 0.5 | HKDC1 HK2 HK3 HK1 | Neomycin, kanamycin and gentamicin biosynthesis |
| GO:0004340 | 8.53661148134e-09 | 0.5 | HKDC1 HK2 HK3 HK1 | glucokinase activity |
| GO:0004396 | 8.53661148134e-09 | 0.5 | HKDC1 HK2 HK3 HK1 | hexokinase activity |
| GO:0008865 | 8.53661148134e-09 | 0.5 | HKDC1 HK2 HK3 HK1 | fructokinase activity |
| GO:0019158 | 8.53661148134e-09 | 0.5 | HKDC1 HK2 HK3 HK1 | mannokinase activity |
| KEGG:00052 | 2.86750784815e-08 | 0.5 | HKDC1 HK2 HK3 HK1 | Galactose metabolism |
| KEGG:00500 | 5.13666714164e-08 | 0.5 | HKDC1 HK2 HK3 HK1 | Starch and sucrose metabolism |
| KEGG:00051 | 6.67732298214e-08 | 0.5 | HKDC1 HK2 HK3 HK1 | Fructose and mannose metabolism |
| WP:WP500 | 1.26654427598e-07 | 0.5 | HKDC1 HK2 HK3 HK1 | Glycogen Synthesis and Degradation |
| KEGG:04973 | 1.48905604463e-07 | 0.5 | HKDC1 HK2 HK3 HK1 | Carbohydrate digestion and absorption |
| KEGG:04930 | 2.20994450988e-07 | 0.5 | HKDC1 HK2 HK3 HK1 | Type II diabetes mellitus |
| KEGG:00520 | 2.65540961466e-07 | 0.5 | HKDC1 HK2 HK3 HK1 | Amino sugar and nucleotide sugar metabolism |
| KEGG:00010 | 9.65745705676e-07 | 0.5 | HKDC1 HK2 HK3 HK1 | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 1.24161539819e-06 | 0.5 | HKDC1 HK2 HK3 HK1 | Central carbon metabolism in cancer |
| KEGG:04066 | 6.30690370715e-06 | 0.5 | HKDC1 HK2 HK3 HK1 | HIF-1 signaling pathway |
| GO:0019200 | 1.01832303085e-05 | 0.5 | HKDC1 HK2 HK3 HK1 | carbohydrate kinase activity |
| GO:0051156 | 1.01832303085e-05 | 0.5 | HKDC1 HK2 HK3 HK1 | glucose 6-phosphate metabolic process |
| KEGG:01200 | 1.07002606102e-05 | 0.5 | HKDC1 HK2 HK3 HK1 | Carbon metabolism |
| KEGG:04910 | 1.55036637537e-05 | 0.5 | HKDC1 HK2 HK3 HK1 | Insulin signaling pathway |
| WP:WP534 | 6.74740784264e-05 | 0.375 | HK2 HK3 HK1 | Glycolysis and Gluconeogenesis |
| GO:0006734 | 8.88204130675e-05 | 0.5 | HK2 NUDT13 HK1 HK3 | NADH metabolic process |
| WP:WP4018 | 0.000414793508617 | 0.375 | HK2 HK3 HK1 | Pathways in clear cell renal cell carcinoma |
| GO:0006002 | 0.000609225680053 | 0.375 | HK2 HK3 HK1 | fructose 6-phosphate metabolic process |
| REAC:R-HSA-70171 | 0.000812270452605 | 0.375 | HK2 HK3 HK1 | Glycolysis |
| GO:0001678 | 0.0010043755339 | 0.5 | HKDC1 HK2 HK3 HK1 | cellular glucose homeostasis |
| REAC:R-HSA-70326 | 0.00156566042435 | 0.375 | HK2 HK3 HK1 | Glucose metabolism |
| GO:0006096 | 0.00489133554292 | 0.5 | HKDC1 HK2 HK3 HK1 | glycolytic process |
| GO:0006757 | 0.00510762571189 | 0.5 | HKDC1 HK2 HK3 HK1 | ATP generation from ADP |
| GO:0046031 | 0.00556156731761 | 0.5 | HKDC1 HK2 HK3 HK1 | ADP metabolic process |
| GO:0009179 | 0.00604500554495 | 0.5 | HKDC1 HK2 HK3 HK1 | purine ribonucleoside diphosphate metabolic process |
| GO:0009135 | 0.00604500554495 | 0.5 | HKDC1 HK2 HK3 HK1 | purine nucleoside diphosphate metabolic process |
| GO:0009185 | 0.00655917985544 | 0.5 | HKDC1 HK2 HK3 HK1 | ribonucleoside diphosphate metabolic process |
| GO:0006165 | 0.00682818709384 | 0.5 | HKDC1 HK2 HK3 HK1 | nucleoside diphosphate phosphorylation |
| GO:0046939 | 0.00710535428194 | 0.5 | HKDC1 HK2 HK3 HK1 | nucleotide phosphorylation |
| GO:0042593 | 0.00861930713405 | 0.5 | HKDC1 HK2 HK3 HK1 | glucose homeostasis |
| GO:0009132 | 0.00861930713405 | 0.5 | HKDC1 HK2 HK3 HK1 | nucleoside diphosphate metabolic process |
| GO:0033500 | 0.00894888598316 | 0.5 | HKDC1 HK2 HK3 HK1 | carbohydrate homeostasis |
| KEGG:01100 | 0.0101915709661 | 0.625 | AASS HK2 HK3 HK1 HKDC1 | Metabolic pathways |
| GO:0061621 | 0.0147863948461 | 0.375 | HK2 HK3 HK1 | canonical glycolysis |
| GO:0061718 | 0.0147863948461 | 0.375 | HK2 HK3 HK1 | glucose catabolic process to pyruvate |
| GO:0061620 | 0.0147863948461 | 0.375 | HK2 HK3 HK1 | glycolytic process through glucose-6-phosphate |
| GO:0061615 | 0.0147863948461 | 0.375 | HK2 HK3 HK1 | glycolytic process through fructose-6-phosphate |
| GO:0006735 | 0.0147863948461 | 0.375 | HK2 HK3 HK1 | NADH regeneration |
| GO:0006090 | 0.0161238103039 | 0.5 | HKDC1 HK2 HK3 HK1 | pyruvate metabolic process |
| GO:0006007 | 0.0205085054668 | 0.375 | HK2 HK3 HK1 | glucose catabolic process |
| GO:0009117 | 0.031091538727 | 0.625 | HKDC1 HK2 NUDT13 HK1 HK3 | nucleotide metabolic process |
| GO:0006753 | 0.0331242369092 | 0.625 | HKDC1 HK2 NUDT13 HK1 HK3 | nucleoside phosphate metabolic process |
| GO:0016052 | 0.0372545640049 | 0.5 | HKDC1 HK2 HK3 HK1 | carbohydrate catabolic process |
| GO:0072656 | 0.0378589948753 | 0.25 | HK1 HK2 | maintenance of protein location in mitochondrion |
| CORUM:7418 | 0.0497224828424 | 0.125 | HK1 | HK1-VDAC1 complex |
| GO:0019674 | 0.0497817121827 | 0.375 | HK2 HK3 HK1 | NAD metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HK1 | HKDC1 | 1.0 | 0.949 | bioplex (HK1) bioplex_WMM |
| HK3 | HKDC1 | 0.798 | 0.764 | bioplex (HK3) bioplex_WMM |
| HK1 | HK2 | 0.711 | 0.728 | bioplex (HK1) bioplex_WMM boldt youn_WMM boldt_WMM |
| HK1 | NUDT13 | 0.042 | 0.269 | fraction |
| HK1 | FKBP2 | 0.031 | 0.24 | bioplex_WMM fraction |
| HK1 | AASS | 0.03 | 0.236 | bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| HK2 | AASS | 0.025 | 0.215 | bioplex_WMM fraction boldt_WMM |
| FKBP2 | TRPC5 | 0.02 | 0.187 | fraction |
| HK2 | HK3 | 0.019 | 0.184 | bioplex (HK3) bioplex_WMM |
| HK1 | HK3 | 0.013 | 0.152 | bioplex (HK3) bioplex_WMM |
| HK2 | HKDC1 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| AASS | FKBP2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| HK2 | FKBP2 | 0.006 | 0.001 | bioplex_WMM WMM_only |
| NUDT13 | AASS | 0.0 | 0.013 | fraction |
| HK2 | NUDT13 | 0.0 | 0.012 | fraction |
Images
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Complex HuMAP2_01636 has an average edge precision of 0.264 which is ranked 5143 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FKBP2 | HuMAP2_01636 HuMAP2_03277 HuMAP2_05984 HuMAP2_06767 HuMAP2_06776 |
| TRPC5 | HuMAP2_01636 |
| AASS | HuMAP2_01636 HuMAP2_02487 HuMAP2_02895 HuMAP2_06671 |
| NUDT13 | HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 |
| HK3 | HuMAP2_01222 HuMAP2_01580 HuMAP2_01636 HuMAP2_02487 |
| HKDC1 | HuMAP2_01222 HuMAP2_01580 HuMAP2_01636 HuMAP2_02487 |
| HK1 | HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918 |
| HK2 | HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918 |