hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01637
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CHMP5 | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | UniProt NCBI |
| CHMP4A | Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) | UniProt NCBI |
| VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | UniProt NCBI |
| CHMP4B | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162588 | 1.85687404714e-09 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 2.85355515963e-09 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| CORUM:1186 | 8.09991585269e-08 | 0.75 | CHMP5 CHMP4A CHMP4B | ESCRT-III complex |
| GO:0046755 | 3.08603851103e-07 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | viral budding |
| GO:0036258 | 6.68560358851e-07 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | multivesicular body assembly |
| GO:0036257 | 7.6760633794e-07 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | multivesicular body organization |
| REAC:R-HSA-162599 | 1.12976343415e-06 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 1.64727717851e-06 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | HIV Life Cycle |
| GO:0019068 | 2.00655931676e-06 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | virion assembly |
| KEGG:04144 | 2.0886994429e-06 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Endocytosis |
| REAC:R-HSA-162906 | 9.09536403708e-06 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | HIV Infection |
| GO:0007032 | 2.23681682258e-05 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | endosome organization |
| REAC:R-HSA-5663205 | 6.10347103542e-05 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Infectious disease |
| KEGG:04217 | 0.000153246296181 | 0.75 | CHMP5 CHMP4A CHMP4B | Necroptosis |
| GO:0061952 | 0.000246852342475 | 0.75 | CHMP5 CHMP4A CHMP4B | midbody abscission |
| REAC:R-HSA-199991 | 0.000426145417081 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000528360370521 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Vesicle-mediated transport |
| GO:1902410 | 0.000558907067709 | 0.75 | CHMP5 CHMP4A CHMP4B | mitotic cytokinetic process |
| GO:0016197 | 0.00157802566628 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | endosomal transport |
| GO:0032506 | 0.00237379826551 | 0.75 | CHMP5 CHMP4A CHMP4B | cytokinetic process |
| REAC:R-HSA-1643685 | 0.00304553054305 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | Disease |
| GO:0019058 | 0.00307362739117 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | viral life cycle |
| REAC:R-HSA-9615710 | 0.00352159938331 | 0.5 | CHMP4B CHMP4A | Microautophagy |
| GO:0007080 | 0.00480126971785 | 0.75 | CHMP5 CHMP4A CHMP4B | mitotic metaphase plate congression |
| GO:0016050 | 0.00512711596139 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | vesicle organization |
| GO:0051310 | 0.00950554068334 | 0.75 | CHMP5 CHMP4A CHMP4B | metaphase plate congression |
| GO:0010256 | 0.0122750656924 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | endomembrane system organization |
| GO:0051303 | 0.0123955582974 | 0.75 | CHMP5 CHMP4A CHMP4B | establishment of chromosome localization |
| GO:0050000 | 0.0130360493673 | 0.75 | CHMP5 CHMP4A CHMP4B | chromosome localization |
| GO:0000281 | 0.017346559408 | 0.75 | CHMP5 CHMP4A CHMP4B | mitotic cytokinesis |
| GO:0016032 | 0.0358963427874 | 1.0 | CHMP5 CHMP4B CHMP4A VTA1 | viral process |
| REAC:R-HSA-1632852 | 0.0373320991746 | 0.5 | CHMP4B CHMP4A | Macroautophagy |
| GO:0006997 | 0.0454154921687 | 0.75 | CHMP5 CHMP4A CHMP4B | nucleus organization |
| GO:0061640 | 0.0454154921687 | 0.75 | CHMP5 CHMP4A CHMP4B | cytoskeleton-dependent cytokinesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CHMP5 | CHMP4A | 0.988 | 0.901 | hein_WMM bioplex_WMM Guru fraction |
| CHMP5 | CHMP4B | 0.944 | 0.856 | hein_WMM bioplex (CHMP5) bioplex_WMM Guru youn_WMM hein (CHMP4B) gupta_WMM fraction |
| CHMP5 | VTA1 | 0.778 | 0.753 | hein_WMM bioplex (CHMP5) bioplex_WMM |
| CHMP4B | VTA1 | 0.007 | 0.001 | hein_WMM bioplex_WMM WMM_only |
| CHMP4A | VTA1 | 0.007 | 0.001 | WMM_only bioplex_WMM |
| CHMP4A | CHMP4B | 0.006 | 0.008 | hein_WMM bioplex_WMM hein (CHMP4B) treiber_WMM |
Images
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Complex HuMAP2_01637 has an average edge precision of 0.42 which is ranked 3106 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CHMP5 | HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627 |
| CHMP4A | HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627 |
| VTA1 | HuMAP2_00578 HuMAP2_01637 HuMAP2_06208 HuMAP2_06627 HuMAP2_06668 |
| CHMP4B | HuMAP2_00024 HuMAP2_00246 HuMAP2_01637 HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528 |