hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01641
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GRAP2 | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | UniProt NCBI |
| GAREM1 | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | UniProt NCBI |
| PTPN23 | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | UniProt NCBI |
| GAB2 | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | UniProt NCBI |
| GAB1 | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3676 | 0.00164969486671 | 0.4 | GAB1 GAB2 | BDNF-TrkB Signaling |
| REAC:R-HSA-109704 | 0.00472180750517 | 0.4 | GAB1 GAB2 | PI3K Cascade |
| REAC:R-HSA-112399 | 0.00625202329777 | 0.4 | GAB1 GAB2 | IRS-mediated signalling |
| REAC:R-HSA-8853659 | 0.00625202329777 | 0.4 | GAB1 GAB2 | RET signaling |
| REAC:R-HSA-5655302 | 0.00625202329777 | 0.4 | GAB1 GAB2 | Signaling by FGFR1 in disease |
| REAC:R-HSA-2428924 | 0.0075397219523 | 0.4 | GAB1 GAB2 | IGF1R signaling cascade |
| REAC:R-HSA-2428928 | 0.0075397219523 | 0.4 | GAB1 GAB2 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-1433557 | 0.00799559968784 | 0.4 | GRAP2 GAB2 | Signaling by SCF-KIT |
| REAC:R-HSA-2404192 | 0.00799559968784 | 0.4 | GAB1 GAB2 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-74751 | 0.00846479084427 | 0.4 | GAB1 GAB2 | Insulin receptor signalling cascade |
| WP:WP69 | 0.00967312592693 | 0.4 | GRAP2 GAB2 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| WP:WP23 | 0.0126363339816 | 0.4 | GAB1 GAB2 | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-1226099 | 0.0184727645209 | 0.4 | GAB1 GAB2 | Signaling by FGFR in disease |
| REAC:R-HSA-74752 | 0.0229182830201 | 0.4 | GAB1 GAB2 | Signaling by Insulin receptor |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | GRAP2 GAB2 GAB1 | Signaling by Receptor Tyrosine Kinases |
| KEGG:04072 | 0.0332521613209 | 0.4 | GAB1 GAB2 | Phospholipase D signaling pathway |
| WP:WP4223 | 0.0390434201563 | 0.4 | GAB1 GAB2 | Ras Signaling |
| WP:WP437 | 0.0415833403121 | 0.4 | GAB1 GAB2 | EGF/EGFR Signaling Pathway |
| CORUM:904 | 0.0499494897235 | 0.2 | GAB1 | SHC3-GAB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRAP2 | GAB2 | 1.0 | 0.949 | bioplex (GRAP2) bioplex_WMM |
| GAREM1 | GRAP2 | 0.98 | 0.896 | bioplex (GRAP2) bioplex_WMM |
| GRAP2 | PTPN23 | 0.979 | 0.895 | bioplex (GRAP2) bioplex_WMM |
| GAB1 | GRAP2 | 0.888 | 0.818 | bioplex (GRAP2) bioplex_WMM |
| GAREM1 | GAB2 | 0.01 | 0.134 | bioplex_WMM WMM_only |
| GAB2 | PTPN23 | 0.01 | 0.126 | bioplex_WMM WMM_only |
| GAB1 | GAB2 | 0.01 | 0.116 | bioplex_WMM WMM_only |
| GAREM1 | PTPN23 | 0.01 | 0.101 | bioplex_WMM WMM_only |
| GAB1 | GAREM1 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| GAB1 | PTPN23 | 0.009 | 0.111 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01641 has an average edge precision of 0.425 which is ranked 3076 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GRAP2 | HuMAP2_00491 HuMAP2_01641 HuMAP2_06196 |
| GAREM1 | HuMAP2_00491 HuMAP2_01641 |
| PTPN23 | HuMAP2_00491 HuMAP2_01641 HuMAP2_04541 |
| GAB2 | HuMAP2_00491 HuMAP2_01641 HuMAP2_05521 |
| GAB1 | HuMAP2_00491 HuMAP2_01641 |