hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01643
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CD274 | Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) | UniProt NCBI |
| PDGFRB | Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) | UniProt NCBI |
| PDGFRA | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | UniProt NCBI |
| ATR | Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) | UniProt NCBI |
| DEPDC1 | DEP domain-containing protein 1A | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP322 | 0.00015011307213 | 0.4 | PDGFRB PDGFRA | Osteoblast Signaling |
| WP:WP3640 | 0.000509836133129 | 0.4 | PDGFRB PDGFRA | Imatinib and Chronic Myeloid Leukemia |
| HP:0005547 | 0.00167158658755 | 0.4 | PDGFRB PDGFRA | Myeloproliferative disorder |
| GO:0005017 | 0.00450823411379 | 0.4 | PDGFRB PDGFRA | platelet-derived growth factor-activated receptor activity |
| GO:0072277 | 0.00450823411379 | 0.4 | PDGFRB PDGFRA | metanephric glomerular capillary formation |
| GO:0072276 | 0.00450823411379 | 0.4 | PDGFRB PDGFRA | metanephric glomerulus vasculature morphogenesis |
| GO:0072275 | 0.00450823411379 | 0.4 | PDGFRB PDGFRA | metanephric glomerulus morphogenesis |
| REAC:R-HSA-186763 | 0.00472180750517 | 0.4 | PDGFRB PDGFRA | Downstream signal transduction |
| WP:WP4538 | 0.00510552962608 | 0.4 | PDGFRB PDGFRA | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:05218 | 0.00805388520034 | 0.4 | PDGFRB PDGFRA | Melanoma |
| KEGG:05230 | 0.00941045001151 | 0.4 | PDGFRB PDGFRA | Central carbon metabolism in cancer |
| KEGG:05214 | 0.00969431019543 | 0.4 | PDGFRB PDGFRA | Glioma |
| WP:WP4018 | 0.0104424923561 | 0.4 | PDGFRB PDGFRA | Pathways in clear cell renal cell carcinoma |
| WP:WP2261 | 0.0109715753892 | 0.4 | PDGFRB PDGFRA | Signaling Pathways in Glioblastoma |
| KEGG:01521 | 0.0114851584748 | 0.4 | PDGFRB PDGFRA | EGFR tyrosine kinase inhibitor resistance |
| WP:WP4540 | 0.0123508080289 | 0.4 | PDGFRB PDGFRA | Pathways Regulating Hippo Signaling |
| REAC:R-HSA-2219530 | 0.0132857243802 | 0.4 | PDGFRB PDGFRA | Constitutive Signaling by Aberrant PI3K in Cancer |
| GO:0038086 | 0.0135228859698 | 0.4 | PDGFRB PDGFRA | VEGF-activated platelet-derived growth factor receptor signaling pathway |
| GO:0072103 | 0.0135228859698 | 0.4 | PDGFRB PDGFRA | glomerulus vasculature morphogenesis |
| GO:0038091 | 0.0135228859698 | 0.4 | PDGFRB PDGFRA | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| GO:0072104 | 0.0135228859698 | 0.4 | PDGFRB PDGFRA | glomerular capillary formation |
| KEGG:04540 | 0.01480317908 | 0.4 | PDGFRB PDGFRA | Gap junction |
| WP:WP3931 | 0.0156686618731 | 0.4 | PDGFRB PDGFRA | ESC Pluripotency Pathways |
| KEGG:05231 | 0.016617964273 | 0.4 | PDGFRB PDGFRA | Choline metabolism in cancer |
| WP:WP4541 | 0.0169715520461 | 0.4 | PDGFRB PDGFRA | Hippo-Merlin Signaling Dysregulation |
| KEGG:05215 | 0.0169933560846 | 0.4 | PDGFRB PDGFRA | Prostate cancer |
| REAC:R-HSA-186797 | 0.019180674733 | 0.4 | PDGFRB PDGFRA | Signaling by PDGF |
| GO:0072239 | 0.0270421395626 | 0.4 | PDGFRB PDGFRA | metanephric glomerulus vasculature development |
| GO:0061439 | 0.0270421395626 | 0.4 | PDGFRB PDGFRA | kidney vasculature morphogenesis |
| GO:0061438 | 0.0270421395626 | 0.4 | PDGFRB PDGFRA | renal system vasculature morphogenesis |
| WP:WP51 | 0.0283719124097 | 0.4 | PDGFRB PDGFRA | Regulation of Actin Cytoskeleton |
| KEGG:04630 | 0.030676003082 | 0.4 | PDGFRB PDGFRA | JAK-STAT signaling pathway |
| REAC:R-HSA-6811558 | 0.0313816354582 | 0.4 | PDGFRB PDGFRA | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| HP:0001880 | 0.0325153883173 | 0.4 | PDGFRB PDGFRA | Eosinophilia |
| HP:0020064 | 0.0325153883173 | 0.4 | PDGFRB PDGFRA | Abnormal eosinophil count |
| REAC:R-HSA-2219528 | 0.0332320424718 | 0.4 | PDGFRB PDGFRA | PI3K/AKT Signaling in Cancer |
| KEGG:04072 | 0.0332521613209 | 0.4 | PDGFRB PDGFRA | Phospholipase D signaling pathway |
| HP:0001879 | 0.0360671162807 | 0.4 | PDGFRB PDGFRA | Abnormal eosinophil morphology |
| REAC:R-HSA-199418 | 0.0380875604325 | 0.4 | PDGFRB PDGFRA | Negative regulation of the PI3K/AKT network |
| WP:WP4223 | 0.0390434201563 | 0.4 | PDGFRB PDGFRA | Ras Signaling |
| GO:0072102 | 0.0450641792523 | 0.4 | PDGFRB PDGFRA | glomerulus morphogenesis |
| CORUM:6413 | 0.0499494897235 | 0.2 | PDGFRB | PDGFB-PDGFRB complex |
| CORUM:3183 | 0.0499494897235 | 0.2 | PDGFRA | PDGFRA-SHP-2 complex, PDGF stimulated |
| CORUM:1133 | 0.0499494897235 | 0.2 | ATR | ATR-HDAC2 complex |
| CORUM:265 | 0.0499494897235 | 0.2 | ATR | ATR-ATRIP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDGFRB | ATR | 0.113 | 0.381 | bioplex (PDGFRB) bioplex_WMM |
| CD274 | ATR | 0.083 | 0.35 | bioplex (CD274) bioplex_WMM |
| DEPDC1 | PDGFRB | 0.08 | 0.35 | bioplex (PDGFRB) bioplex_WMM |
| PDGFRB | PDGFRA | 0.033 | 0.253 | bioplex (PDGFRB) bioplex_WMM |
| DEPDC1 | PDGFRA | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ATR | PDGFRA | 0.008 | 0.023 | bioplex_WMM WMM_only |
| DEPDC1 | ATR | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01643 has an average edge precision of 0.203 which is ranked 6138 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CD274 | HuMAP2_01557 HuMAP2_01643 HuMAP2_02150 |
| PDGFRB | HuMAP2_01557 HuMAP2_01643 HuMAP2_01893 |
| PDGFRA | HuMAP2_01643 HuMAP2_01893 |
| ATR | HuMAP2_01557 HuMAP2_01643 HuMAP2_02150 |
| DEPDC1 | HuMAP2_00240 HuMAP2_00717 HuMAP2_01557 HuMAP2_01643 HuMAP2_01893 |