hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01652
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TNKS | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | UniProt NCBI |
| TNKS2 | Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) | UniProt NCBI |
| GMDS | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5545619 | 6.69539719869e-06 | 0.666666666667 | TNKS2 TNKS | XAV939 inhibits tankyrase, stabilizing AXIN |
| CORUM:1219 | 1.00675659188e-05 | 0.666666666667 | TNKS2 TNKS | Tankyrin 1-tankyrin 2-TRF1 complex |
| WP:WP3645 | 0.000163898158608 | 0.666666666667 | TNKS2 TNKS | NAD+ biosynthetic pathways |
| REAC:R-HSA-4791275 | 0.00290884705451 | 0.666666666667 | TNKS2 TNKS | Signaling by WNT in cancer |
| REAC:R-HSA-4641257 | 0.00991907449014 | 0.666666666667 | TNKS2 TNKS | Degradation of AXIN |
| REAC:R-HSA-8948751 | 0.015207050821 | 0.666666666667 | TNKS2 TNKS | Regulation of PTEN stability and activity |
| GO:0070212 | 0.0283955176165 | 0.666666666667 | TNKS2 TNKS | protein poly-ADP-ribosylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TNKS | TNKS2 | 0.475 | 0.609 | hein_WMM bioplex_WMM hein (TNKS,TNKS2) |
| TNKS | GMDS | 0.426 | 0.575 | hein_WMM bioplex (GMDS) bioplex_WMM hein (TNKS) |
| GMDS | TNKS2 | 0.295 | 0.495 | hein_WMM bioplex (GMDS) bioplex_WMM hein (TNKS2) |
Images
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Complex HuMAP2_01652 has an average edge precision of 0.56 which is ranked 2130 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TNKS | HuMAP2_00575 HuMAP2_01652 HuMAP2_04190 HuMAP2_04552 |
| TNKS2 | HuMAP2_01652 HuMAP2_04190 HuMAP2_04552 |
| GMDS | HuMAP2_01015 HuMAP2_01652 HuMAP2_04552 HuMAP2_06471 |