hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01653
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RCC2 | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | UniProt NCBI |
| NSMCE2 | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | UniProt NCBI |
| SMC5 | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | UniProt NCBI |
| SMC6 | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051984 | 3.08603851103e-07 | 1.0 | RCC2 NSMCE2 SMC5 SMC6 | positive regulation of chromosome segregation |
| GO:0030915 | 1.27120391093e-05 | 0.75 | SMC6 SMC5 NSMCE2 | Smc5-Smc6 complex |
| GO:0106068 | 1.27120391093e-05 | 0.75 | SMC6 SMC5 NSMCE2 | SUMO ligase complex |
| GO:0000722 | 4.35775472874e-05 | 0.75 | SMC6 SMC5 NSMCE2 | telomere maintenance via recombination |
| GO:0051983 | 6.2335294411e-05 | 1.0 | RCC2 NSMCE2 SMC5 SMC6 | regulation of chromosome segregation |
| REAC:R-HSA-3108214 | 7.69213089466e-05 | 0.75 | SMC6 SMC5 NSMCE2 | SUMOylation of DNA damage response and repair proteins |
| GO:0006312 | 0.000246852342475 | 0.75 | SMC6 SMC5 NSMCE2 | mitotic recombination |
| REAC:R-HSA-3108232 | 0.0010027366871 | 0.75 | SMC6 SMC5 NSMCE2 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.00111581489513 | 0.75 | SMC6 SMC5 NSMCE2 | SUMOylation |
| GO:0007059 | 0.00400233274596 | 1.0 | RCC2 NSMCE2 SMC5 SMC6 | chromosome segregation |
| GO:0098687 | 0.00552286185544 | 1.0 | RCC2 NSMCE2 SMC5 SMC6 | chromosomal region |
| GO:0090398 | 0.00710332146687 | 0.75 | SMC6 SMC5 NSMCE2 | cellular senescence |
| GO:0035061 | 0.00811409485621 | 0.5 | SMC6 SMC5 | interchromatin granule |
| GO:0016605 | 0.0130360493673 | 0.75 | SMC6 SMC5 NSMCE2 | PML body |
| GO:0007569 | 0.0189701239271 | 0.75 | SMC6 SMC5 NSMCE2 | cell aging |
| GO:0034093 | 0.0270421395626 | 0.5 | NSMCE2 SMC5 | positive regulation of maintenance of sister chromatid cohesion |
| GO:0034184 | 0.0270421395626 | 0.5 | NSMCE2 SMC5 | positive regulation of maintenance of mitotic sister chromatid cohesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMC6 | SMC5 | 0.991 | 0.911 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| SMC6 | NSMCE2 | 0.99 | 0.909 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| SMC5 | NSMCE2 | 0.886 | 0.817 | hein_WMM bioplex_WMM Malo fraction |
| SMC6 | RCC2 | 0.764 | 0.749 | bioplex_WMM fraction |
| SMC5 | RCC2 | 0.007 | 0.004 | bioplex_WMM fraction |
| NSMCE2 | RCC2 | 0.0 | 0.009 | fraction |
Images
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Complex HuMAP2_01653 has an average edge precision of 0.567 which is ranked 2097 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RCC2 | HuMAP2_01653 |
| NSMCE2 | HuMAP2_00383 HuMAP2_00828 HuMAP2_01653 HuMAP2_04865 HuMAP2_05208 |
| SMC5 | HuMAP2_00383 HuMAP2_00828 HuMAP2_01653 HuMAP2_04865 HuMAP2_05208 |
| SMC6 | HuMAP2_00383 HuMAP2_00828 HuMAP2_01653 HuMAP2_03675 HuMAP2_04865 HuMAP2_05208 |