hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01677
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS29 | Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29) | UniProt NCBI |
| VPS35 | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | UniProt NCBI |
| SNX32 | Sorting nexin-32 (Sorting nexin-6B) | UniProt NCBI |
| ANKRD27 | Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) | UniProt NCBI |
| VPS26A | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | UniProt NCBI |
| TBC1D5 | TBC1 domain family member 5 | UniProt NCBI |
| SNX2 | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | UniProt NCBI |
| MTMR10 | Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) | UniProt NCBI |
| VPS26B | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | UniProt NCBI |
| UBLCP1 | Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1) | UniProt NCBI |
| SNX1 | Sorting nexin-1 | UniProt NCBI |
| SNX6 | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | UniProt NCBI |
| SNX5 | Sorting nexin-5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030904 | 1.74926719965e-20 | 0.692307692308 | SNX6 SNX2 VPS35 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX5 | retromer complex |
| GO:0016482 | 1.65908412491e-16 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | cytosolic transport |
| GO:0042147 | 1.79647783856e-16 | 0.769230769231 | SNX6 SNX2 VPS35 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX5 | retrograde transport, endosome to Golgi |
| GO:0016197 | 7.39819913746e-15 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | endosomal transport |
| CORUM:1060 | 1.20767597202e-14 | 0.384615384615 | VPS26B SNX1 VPS29 SNX2 VPS35 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| CORUM:1059 | 1.20767597202e-14 | 0.384615384615 | VPS35 SNX2 VPS26A VPS29 SNX1 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:657 | 1.20767597202e-14 | 0.384615384615 | VPS35 SNX2 VPS26A VPS29 SNX1 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| KEGG:04144 | 1.53483425365e-12 | 0.692307692308 | SNX6 SNX2 VPS35 SNX32 VPS26B VPS26A SNX1 VPS29 SNX5 | Endocytosis |
| GO:0097422 | 1.05430112357e-11 | 0.384615384615 | VPS35 VPS26A ANKRD27 SNX5 SNX6 | tubular endosome |
| GO:0005768 | 1.77130146213e-09 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | endosome |
| GO:0030906 | 1.74428263667e-08 | 0.307692307692 | VPS26B VPS26A VPS29 VPS35 | retromer, cargo-selective complex |
| GO:0030905 | 1.74428263667e-08 | 0.307692307692 | SNX1 SNX2 SNX5 SNX6 | retromer, tubulation complex |
| CORUM:656 | 2.97527064635e-08 | 0.230769230769 | VPS35 VPS29 VPS26A | VPS35-VPS29-VPS26A complex |
| GO:0044440 | 2.0972104433e-06 | 0.615384615385 | SNX6 ANKRD27 SNX5 VPS35 VPS26A SNX1 TBC1D5 SNX2 | endosomal part |
| GO:0005769 | 9.14058355176e-06 | 0.538461538462 | SNX6 ANKRD27 VPS35 VPS26B VPS26A SNX1 SNX5 | early endosome |
| GO:0046907 | 1.94486282518e-05 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | intracellular transport |
| GO:0016236 | 3.20898865717e-05 | 0.538461538462 | SNX6 VPS35 SNX32 VPS26B VPS26A TBC1D5 SNX5 | macroautophagy |
| CORUM:1058 | 4.02797549685e-05 | 0.153846153846 | SNX1 SNX6 | SNX complex (SNX1, SNX6) |
| GO:0016192 | 4.70076894069e-05 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | vesicle-mediated transport |
| GO:0031410 | 4.97069497683e-05 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | cytoplasmic vesicle |
| GO:0097708 | 5.00540412114e-05 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | intracellular vesicle |
| GO:0010008 | 5.29136893753e-05 | 0.538461538462 | SNX6 SNX2 VPS35 VPS26A SNX1 TBC1D5 SNX5 | endosome membrane |
| GO:0016241 | 5.96985146423e-05 | 0.461538461538 | SNX6 VPS35 SNX32 VPS26B VPS26A SNX5 | regulation of macroautophagy |
| CORUM:1070 | 0.000120779759493 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4) |
| GO:0051649 | 0.000181531030958 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | establishment of localization in cell |
| GO:0098796 | 0.00021106209992 | 0.692307692308 | SNX6 SNX2 VPS35 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX5 | membrane protein complex |
| REAC:R-HSA-3238698 | 0.000217889511228 | 0.230769230769 | VPS35 VPS29 VPS26A | WNT ligand biogenesis and trafficking |
| GO:1990126 | 0.00021842115969 | 0.307692307692 | VPS35 VPS26A VPS29 ANKRD27 | retrograde transport, endosome to plasma membrane |
| CORUM:1095 | 0.000241440568101 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, EGFR) |
| CORUM:1091 | 0.000241440568101 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, LEPR) |
| CORUM:1093 | 0.000241440568101 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, INSR) |
| CORUM:1096 | 0.000241440568101 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, PDGFRA) |
| GO:0061919 | 0.000654512321883 | 0.538461538462 | SNX6 VPS35 SNX32 VPS26B VPS26A TBC1D5 SNX5 | process utilizing autophagic mechanism |
| GO:0006914 | 0.000654512321883 | 0.538461538462 | SNX6 VPS35 SNX32 VPS26B VPS26A TBC1D5 SNX5 | autophagy |
| GO:0010506 | 0.00221495348809 | 0.461538461538 | SNX6 VPS35 SNX32 VPS26B VPS26A SNX5 | regulation of autophagy |
| GO:0051641 | 0.00339052430855 | 0.846153846154 | SNX6 ANKRD27 VPS35 SNX5 SNX32 TBC1D5 VPS26B VPS26A SNX1 VPS29 SNX2 | cellular localization |
| GO:0005773 | 0.00757026806687 | 0.538461538462 | SNX6 ANKRD27 VPS35 VPS26A SNX1 TBC1D5 SNX2 | vacuole |
| GO:0098876 | 0.0204843211717 | 0.307692307692 | VPS35 VPS26A VPS29 ANKRD27 | vesicle-mediated transport to the plasma membrane |
| GO:0044433 | 0.0262027380643 | 0.615384615385 | SNX6 ANKRD27 SNX5 VPS35 VPS26A SNX1 TBC1D5 SNX2 | cytoplasmic vesicle part |
| CORUM:1072 | 0.0499905325622 | 0.0769230769231 | SNX2 | SNX complex (SNX2), oligomeric |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS35 | VPS26A | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM Guru hein (VPS26A) gupta_WMM fraction |
| VPS26A | VPS29 | 1.0 | 0.949 | hein_WMM bioplex (VPS26A,VPS29) bioplex_WMM Guru hein (VPS26A) gupta_WMM fraction |
| VPS26A | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM hein (VPS26A) gupta_WMM |
| VPS26B | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM hein (VPS26B) |
| VPS26B | VPS29 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B,VPS29) bioplex_WMM Guru hein (VPS26B) fraction boldt_WMM |
| VPS26B | VPS35 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM Guru boldt hein (VPS26B) fraction boldt_WMM |
| SNX2 | VPS26A | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction |
| VPS35 | VPS29 | 0.999 | 0.949 | hein_WMM bioplex (VPS29) bioplex_WMM Guru gupta_WMM fraction boldt_WMM |
| SNX2 | SNX6 | 0.993 | 0.918 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SNX2 | SNX5 | 0.99 | 0.909 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SNX1 | VPS26B | 0.988 | 0.901 | fraction |
| VPS26B | SNX2 | 0.988 | 0.901 | fraction |
| SNX1 | VPS35 | 0.988 | 0.901 | youn_WMM gupta_WMM fraction |
| SNX2 | VPS35 | 0.988 | 0.902 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SNX1 | VPS26A | 0.952 | 0.858 | youn_WMM gupta_WMM fraction |
| SNX1 | SNX6 | 0.951 | 0.858 | bioplex (SNX1) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| VPS26B | VPS26A | 0.888 | 0.818 | bioplex (VPS26A,VPS26B) bioplex_WMM fraction |
| TBC1D5 | VPS29 | 0.884 | 0.816 | hein_WMM bioplex (VPS29) bioplex_WMM gupta_WMM |
| SNX32 | SNX1 | 0.582 | 0.664 | bioplex (SNX1,SNX32) bioplex_WMM |
| SNX1 | SNX5 | 0.567 | 0.654 | bioplex (SNX1) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| ANKRD27 | VPS29 | 0.461 | 0.599 | hein_WMM bioplex (VPS29) bioplex_WMM |
| VPS26A | SNX5 | 0.288 | 0.489 | bioplex_WMM fraction |
| SNX1 | SNX2 | 0.273 | 0.485 | bioplex (SNX1) bioplex_WMM youn_WMM gupta_WMM |
| ANKRD27 | VPS26A | 0.207 | 0.455 | hein_WMM bioplex_WMM hein (VPS26A) |
| VPS26B | ANKRD27 | 0.144 | 0.406 | hein_WMM bioplex_WMM hein (VPS26B) |
| SNX32 | SNX6 | 0.065 | 0.346 | bioplex (SNX32) bioplex_WMM |
| SNX6 | VPS26A | 0.056 | 0.313 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| SNX1 | VPS29 | 0.047 | 0.292 | gupta_WMM fraction |
| SNX2 | UBLCP1 | 0.035 | 0.266 | bioplex_WMM youn_WMM gupta_WMM fraction |
| VPS26A | UBLCP1 | 0.034 | 0.264 | bioplex_WMM gupta_WMM fraction |
| SNX5 | UBLCP1 | 0.031 | 0.24 | bioplex_WMM fraction |
| VPS26B | SNX6 | 0.025 | 0.218 | fraction |
| SNX1 | MTMR10 | 0.025 | 0.212 | gupta_WMM fraction |
| SNX2 | VPS29 | 0.024 | 0.214 | bioplex_WMM fraction |
| VPS35 | TBC1D5 | 0.019 | 0.182 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| VPS35 | SNX6 | 0.017 | 0.176 | bioplex_WMM gupta_WMM fraction |
| SNX2 | MTMR10 | 0.016 | 0.165 | fraction |
| ANKRD27 | TBC1D5 | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| VPS35 | ANKRD27 | 0.01 | 0.14 | hein_WMM bioplex_WMM WMM_only |
| SNX6 | MTMR10 | 0.01 | 0.121 | fraction |
| VPS26A | MTMR10 | 0.009 | 0.091 | fraction |
| SNX32 | SNX5 | 0.008 | 0.05 | bioplex_WMM WMM_only |
| SNX6 | SNX5 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| TBC1D5 | UBLCP1 | 0.007 | 0.004 | youn_WMM gupta_WMM WMM_only |
| VPS35 | UBLCP1 | 0.007 | 0.0 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| VPS29 | UBLCP1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| SNX1 | UBLCP1 | 0.007 | 0.006 | youn_WMM gupta_WMM WMM_only |
| SNX6 | UBLCP1 | 0.007 | 0.0 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SNX6 | TBC1D5 | 0.007 | 0.001 | youn_WMM gupta_WMM WMM_only |
| VPS35 | SNX5 | 0.006 | 0.008 | bioplex_WMM gupta_WMM fraction |
| VPS35 | MTMR10 | 0.005 | 0.008 | fraction |
| SNX32 | SNX2 | 0.005 | 0.011 | bioplex (SNX32) bioplex_WMM |
| SNX6 | VPS29 | 0.004 | 0.008 | bioplex_WMM fraction |
| SNX5 | VPS29 | 0.004 | 0.014 | bioplex_WMM fraction |
| MTMR10 | UBLCP1 | 0.0 | 0.014 | fraction |
| SNX1 | TBC1D5 | 0.0 | 0.018 | youn_WMM gupta_WMM fraction |
| VPS26B | SNX5 | 0.0 | 0.013 | fraction |
| VPS29 | MTMR10 | 0.0 | 0.013 | fraction |
| SNX2 | TBC1D5 | 0.0 | 0.012 | youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_01677 has an average edge precision of 0.402 which is ranked 3300 out of all 6965 complexes.
Related Complexes