hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01678
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BIRC5 | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | UniProt NCBI |
| LAMTOR4 | Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed] | UniProt NCBI |
| CDCA8 | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | UniProt NCBI |
| INCENP | Inner centromere protein | UniProt NCBI |
| CCDC102A | Coiled-coil domain-containing protein 102A | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1120 | 1.35146690511e-09 | 0.6 | INCENP CDCA8 BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:1119 | 5.40532307664e-09 | 0.6 | INCENP CDCA8 BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1118 | 5.40532307664e-09 | 0.6 | INCENP CDCA8 BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:2582 | 2.0123342217e-05 | 0.4 | CDCA8 BIRC5 | Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) |
| CORUM:2579 | 2.0123342217e-05 | 0.4 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) |
| REAC:R-HSA-4615885 | 3.10929802736e-05 | 0.6 | INCENP CDCA8 BIRC5 | SUMOylation of DNA replication proteins |
| CORUM:1087 | 4.0241279111e-05 | 0.4 | INCENP BIRC5 | BIRC5-AURKB-INCENP-EVI5 complex |
| REAC:R-HSA-141444 | 0.000338412904811 | 0.6 | INCENP CDCA8 BIRC5 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.000338412904811 | 0.6 | INCENP CDCA8 BIRC5 | Amplification of signal from the kinetochores |
| REAC:R-HSA-69618 | 0.000534065976599 | 0.6 | INCENP CDCA8 BIRC5 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 0.000754665480287 | 0.6 | INCENP CDCA8 BIRC5 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.00102865345201 | 0.6 | INCENP CDCA8 BIRC5 | RHO GTPases Activate Formins |
| REAC:R-HSA-3108232 | 0.00200241639833 | 0.6 | INCENP CDCA8 BIRC5 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.00222754987811 | 0.6 | INCENP CDCA8 BIRC5 | SUMOylation |
| REAC:R-HSA-2467813 | 0.00268268573517 | 0.6 | INCENP CDCA8 BIRC5 | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.00304975168622 | 0.6 | INCENP CDCA8 BIRC5 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.00304975168622 | 0.6 | INCENP CDCA8 BIRC5 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00309784557874 | 0.6 | INCENP CDCA8 BIRC5 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69620 | 0.0103005771752 | 0.6 | INCENP CDCA8 BIRC5 | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 0.0128363146831 | 0.6 | INCENP CDCA8 BIRC5 | RHO GTPase Effectors |
| REAC:R-HSA-68886 | 0.0231915667986 | 0.6 | INCENP CDCA8 BIRC5 | M Phase |
| CORUM:2580 | 0.0249780992026 | 0.2 | BIRC5 | Survivin homodimer complex |
| REAC:R-HSA-194315 | 0.034259108007 | 0.6 | INCENP CDCA8 BIRC5 | Signaling by Rho GTPases |
| GO:0032133 | 0.0450641792523 | 0.4 | CDCA8 BIRC5 | chromosome passenger complex |
| CORUM:1117 | 0.0499494897235 | 0.2 | BIRC5 | CRM1-Survivin mitotic complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BIRC5 | CDCA8 | 0.988 | 0.901 | bioplex (BIRC5,CDCA8) bioplex_WMM |
| INCENP | BIRC5 | 0.144 | 0.406 | bioplex (BIRC5) bioplex_WMM |
| BIRC5 | CCDC102A | 0.079 | 0.351 | bioplex (BIRC5) bioplex_WMM |
| BIRC5 | LAMTOR4 | 0.05 | 0.296 | bioplex (BIRC5) bioplex_WMM |
| INCENP | CDCA8 | 0.03 | 0.231 | hein_WMM bioplex_WMM youn_WMM hein (CDCA8) |
| INCENP | CCDC102A | 0.007 | 0.006 | bioplex_WMM WMM_only |
| INCENP | LAMTOR4 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CCDC102A | CDCA8 | 0.007 | 0.008 | hein_WMM bioplex_WMM WMM_only |
| LAMTOR4 | CDCA8 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| LAMTOR4 | CCDC102A | 0.007 | 0.006 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_01678 has an average edge precision of 0.221 which is ranked 5834 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BIRC5 | HuMAP2_01297 HuMAP2_01678 HuMAP2_05304 |
| LAMTOR4 | HuMAP2_01297 HuMAP2_01678 HuMAP2_02685 |
| CDCA8 | HuMAP2_01297 HuMAP2_01678 HuMAP2_05304 |
| INCENP | HuMAP2_01297 HuMAP2_01678 |
| CCDC102A | HuMAP2_01297 HuMAP2_01678 HuMAP2_04110 |