hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01690
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLF1 | SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) | UniProt NCBI |
| SLF2 | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | UniProt NCBI |
| RAD18 | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | UniProt NCBI |
| UBE2A | Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051984 | 0.000834605087859 | 0.75 | SLF1 RAD18 SLF2 | positive regulation of chromosome segregation |
| GO:0031625 | 0.00328877392035 | 1.0 | SLF1 UBE2A RAD18 SLF2 | ubiquitin protein ligase binding |
| GO:0044389 | 0.00413169328387 | 1.0 | SLF1 UBE2A RAD18 SLF2 | ubiquitin-like protein ligase binding |
| GO:1990166 | 0.00811409485621 | 0.5 | SLF1 SLF2 | protein localization to site of double-strand break |
| GO:0035861 | 0.00950554068334 | 0.75 | SLF1 RAD18 SLF2 | site of double-strand break |
| REAC:R-HSA-8866654 | 0.0154107631021 | 0.5 | UBE2A RAD18 | E3 ubiquitin ligases ubiquitinate target proteins |
| GO:0090734 | 0.0225145500348 | 0.75 | SLF1 RAD18 SLF2 | site of DNA damage |
| GO:0034093 | 0.0270421395626 | 0.5 | SLF1 SLF2 | positive regulation of maintenance of sister chromatid cohesion |
| GO:0034184 | 0.0270421395626 | 0.5 | SLF1 SLF2 | positive regulation of maintenance of mitotic sister chromatid cohesion |
| REAC:R-HSA-8852135 | 0.0277220764292 | 0.5 | UBE2A RAD18 | Protein ubiquitination |
| GO:0051983 | 0.0424904593616 | 0.75 | SLF1 RAD18 SLF2 | regulation of chromosome segregation |
| GO:0006281 | 0.042993565242 | 1.0 | SLF1 UBE2A RAD18 SLF2 | DNA repair |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBE2A | RAD18 | 0.064 | 0.347 | hein_WMM bioplex_WMM hein (RAD18,UBE2A) boldt_WMM |
| SLF1 | RAD18 | 0.04 | 0.267 | hein_WMM youn_WMM hein (RAD18) |
| SLF1 | SLF2 | 0.035 | 0.265 | hein_WMM youn_WMM hein (SLF2) |
| SLF2 | RAD18 | 0.018 | 0.177 | hein_WMM youn_WMM hein (RAD18,SLF2) |
| SLF2 | UBE2A | 0.008 | 0.012 | hein_WMM WMM_only |
| SLF1 | UBE2A | 0.007 | 0.002 | hein_WMM WMM_only |
Images
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Complex HuMAP2_01690 has an average edge precision of 0.178 which is ranked 6444 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLF1 | HuMAP2_00828 HuMAP2_01690 |
| SLF2 | HuMAP2_00828 HuMAP2_01690 HuMAP2_05208 |
| RAD18 | HuMAP2_01690 HuMAP2_02741 |
| UBE2A | HuMAP2_01337 HuMAP2_01690 HuMAP2_02741 HuMAP2_03854 |