hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01695

Confidence: Very High

Genename	Protein Name	Links
YBX1	Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1)	UniProt NCBI
YBX3	Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)	UniProt NCBI
NOP10	H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)	UniProt NCBI
DKC1	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	UniProt NCBI
GAR1	H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)	UniProt NCBI
SHQ1	Protein SHQ1 homolog	UniProt NCBI
NAF1	H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0031118	2.98701137129e-08	0.571428571429	DKC1 GAR1 NOP10 NAF1	rRNA pseudouridine synthesis
CORUM:6245	1.18258642143e-07	0.428571428571	DKC1 NOP10 GAR1	Telomerase holoenzyme
GO:0001522	6.09613706377e-07	0.571428571429	DKC1 GAR1 NOP10 NAF1	pseudouridine synthesis
GO:1904874	1.16343266976e-06	0.571428571429	DKC1 SHQ1 NAF1 NOP10	positive regulation of telomerase RNA localization to Cajal body
GO:1904872	2.60687308082e-06	0.571428571429	DKC1 SHQ1 NAF1 NOP10	regulation of telomerase RNA localization to Cajal body
GO:0090671	3.30150663924e-06	0.571428571429	DKC1 SHQ1 NAF1 NOP10	telomerase RNA localization to Cajal body
GO:0090670	3.30150663924e-06	0.571428571429	DKC1 SHQ1 NAF1 NOP10	RNA localization to Cajal body
GO:0005732	3.30150663924e-06	0.571428571429	DKC1 GAR1 NOP10 NAF1	small nucleolar ribonucleoprotein complex
GO:0090685	3.30150663924e-06	0.571428571429	DKC1 SHQ1 NAF1 NOP10	RNA localization to nucleus
GO:0090672	3.30150663924e-06	0.571428571429	DKC1 SHQ1 NAF1 NOP10	telomerase RNA localization
GO:0070034	6.22776982841e-06	0.571428571429	DKC1 GAR1 NOP10 NAF1	telomerase RNA binding
GO:0090661	1.27120391093e-05	0.428571428571	DKC1 NOP10 GAR1	box H/ACA telomerase RNP complex
GO:0072589	1.27120391093e-05	0.428571428571	DKC1 NOP10 GAR1	box H/ACA scaRNP complex
GO:0072588	1.27120391093e-05	0.428571428571	DKC1 NOP10 GAR1	box H/ACA RNP complex
GO:0031429	1.27120391093e-05	0.428571428571	DKC1 NOP10 GAR1	box H/ACA snoRNP complex
GO:0034513	1.27120391093e-05	0.428571428571	DKC1 NOP10 GAR1	box H/ACA snoRNA binding
GO:0000154	2.33016882025e-05	0.571428571429	DKC1 GAR1 NOP10 NAF1	rRNA modification
GO:0043489	0.00010471199091	0.571428571429	DKC1 YBX3 NAF1 YBX1	RNA stabilization
GO:0006364	0.000205648445059	0.714285714286	DKC1 GAR1 SHQ1 NAF1 NOP10	rRNA processing
GO:1902369	0.000211763495732	0.571428571429	DKC1 YBX3 NAF1 YBX1	negative regulation of RNA catabolic process
KEGG:03008	0.000240117545455	0.428571428571	DKC1 NOP10 GAR1	Ribosome biogenesis in eukaryotes
GO:0016072	0.000265505155617	0.714285714286	DKC1 GAR1 SHQ1 NAF1 NOP10	rRNA metabolic process
HP:0002165	0.000346286800202	0.285714285714	DKC1 NOP10	Pterygium of nails
REAC:R-HSA-6790901	0.000359631908423	0.428571428571	DKC1 NOP10 GAR1	rRNA modification in the nucleus and cytosol
GO:0007004	0.00064783223994	0.571428571429	DKC1 GAR1 NOP10 NAF1	telomere maintenance via telomerase
GO:0006278	0.000688210464691	0.571428571429	DKC1 GAR1 NOP10 NAF1	RNA-dependent DNA biosynthetic process
GO:0042254	0.000959205344393	0.714285714286	DKC1 GAR1 SHQ1 NAF1 NOP10	ribosome biogenesis
GO:0010833	0.00120347761901	0.571428571429	DKC1 GAR1 NOP10 NAF1	telomere maintenance via telomere lengthening
GO:0005697	0.00361126654538	0.428571428571	DKC1 NOP10 GAR1	telomerase holoenzyme complex
GO:0034470	0.00415838115463	0.714285714286	DKC1 GAR1 SHQ1 NAF1 NOP10	ncRNA processing
GO:0030515	0.00560674176034	0.428571428571	DKC1 NOP10 GAR1	snoRNA binding
GO:0006396	0.00636934613966	0.857142857143	GAR1 YBX1 NOP10 DKC1 SHQ1 NAF1	RNA processing
HPA:030010_03	0.00805466886059	0.571428571429	DKC1 GAR1 SHQ1 YBX1	oral mucosa; squamous epithelial cells[Uncertain,High]
GO:0009451	0.0086504135617	0.571428571429	DKC1 GAR1 NOP10 NAF1	RNA modification
HP:0002043	0.00898332183607	0.285714285714	DKC1 NOP10	Esophageal stricture
GO:0022613	0.00928376179311	0.714285714286	DKC1 GAR1 SHQ1 NAF1 NOP10	ribonucleoprotein complex biogenesis
GO:0000493	0.00946729163895	0.285714285714	SHQ1 NAF1	box H/ACA snoRNP assembly
GO:0000454	0.00946729163895	0.285714285714	GAR1 NAF1	snoRNA guided rRNA pseudouridine synthesis
HPA:050020_12	0.0103711433966	0.571428571429	DKC1 GAR1 NOP10 YBX1	spleen; cells in white pulp[Supported,Medium]
HP:0009926	0.0104781956652	0.285714285714	DKC1 NOP10	Epiphora
REAC:R-HSA-8868773	0.0116992025039	0.428571428571	DKC1 NOP10 GAR1	rRNA processing in the nucleus and cytosol
HP:0100670	0.0120875188399	0.285714285714	DKC1 NOP10	Rough bone trabeculation
REAC:R-HSA-72312	0.0136177314146	0.428571428571	DKC1 NOP10 GAR1	rRNA processing
GO:0034660	0.0138615837302	0.714285714286	DKC1 GAR1 SHQ1 NAF1 NOP10	ncRNA metabolic process
GO:0071897	0.0139436058816	0.571428571429	DKC1 GAR1 NOP10 NAF1	DNA biosynthetic process
HP:0011364	0.0156492047667	0.285714285714	DKC1 NOP10	White hair
GO:0000723	0.0168953290765	0.571428571429	DKC1 GAR1 NOP10 NAF1	telomere maintenance
HPA:043010_12	0.0186286048013	0.571428571429	DKC1 GAR1 NOP10 YBX1	skin 1; Langerhans[Supported,Medium]
HPA:006020_12	0.0186286048013	0.571428571429	DKC1 GAR1 NOP10 YBX1	caudate; neuronal cells[Supported,Medium]
REAC:R-HSA-8953854	0.0191594284188	0.571428571429	DKC1 GAR1 NOP10 YBX1	Metabolism of RNA
HP:0025125	0.0196677630092	0.285714285714	DKC1 NOP10	White lesion of the oral mucosa
HP:0002745	0.0196677630092	0.285714285714	DKC1 NOP10	Oral leukoplakia
HP:0200037	0.0196677630092	0.285714285714	DKC1 NOP10	Skin vesicle
HP:0010450	0.0218481766952	0.285714285714	DKC1 NOP10	Esophageal stenosis
HPA:014010_11	0.0224486224646	0.571428571429	DKC1 GAR1 NOP10 YBX1	endometrium 2; cells in endometrial stroma[Supported,Low]
HPA:022020_12	0.0224486224646	0.571428571429	DKC1 GAR1 NOP10 YBX1	hippocampus; neuronal cells[Supported,Medium]
GO:0032200	0.0235853115521	0.571428571429	DKC1 GAR1 NOP10 NAF1	telomere organization
GO:0043487	0.0235853115521	0.571428571429	DKC1 YBX3 NAF1 YBX1	regulation of RNA stability
HPA:043040_12	0.0243502968244	0.571428571429	DKC1 GAR1 NOP10 YBX1	skin 1; melanocytes[Supported,Medium]
GO:0015030	0.0245293846287	0.428571428571	DKC1 NOP10 GAR1	Cajal body
HPA:009010_12	0.0256336957719	0.571428571429	DKC1 GAR1 NOP10 YBX1	cervix, uterine; glandular cells[Supported,Medium]
GO:0031120	0.0283955176165	0.285714285714	DKC1 NOP10	snRNA pseudouridine synthesis
HP:0100671	0.0290730325003	0.285714285714	DKC1 NOP10	Abnormal trabecular bone morphology
HPA:058010_12	0.0291389621527	0.571428571429	DKC1 GAR1 NOP10 YBX1	vagina; squamous epithelial cells[Supported,Medium]
HPA:002020_13	0.0297592023304	0.428571428571	DKC1 YBX1 GAR1	appendix; lymphoid tissue[Supported,High]
HPA:043030_12	0.030767802369	0.571428571429	DKC1 GAR1 NOP10 YBX1	skin 1; keratinocytes[Supported,Medium]
HPA:031020_11	0.0316068164147	0.571428571429	DKC1 GAR1 NOP10 YBX1	ovary; ovarian stroma cells[Supported,Low]
HPA:028010_13	0.0326192827429	0.428571428571	DKC1 YBX1 GAR1	lymph node; germinal center cells[Supported,High]
HPA:050020_11	0.0344047038039	0.571428571429	DKC1 GAR1 NOP10 YBX1	spleen; cells in white pulp[Supported,Low]
HPA:014020_12	0.034948863287	0.571428571429	DKC1 GAR1 NOP10 YBX1	endometrium 2; glandular cells[Supported,Medium]
HPA:030010_12	0.0353151255643	0.571428571429	DKC1 GAR1 NOP10 YBX1	oral mucosa; squamous epithelial cells[Supported,Medium]
HP:0005374	0.0373216957502	0.285714285714	DKC1 NOP10	Cellular immunodeficiency
HPA:058010_02	0.0381034473719	0.714285714286	YBX1 GAR1 DKC1 SHQ1 NOP10	vagina; squamous epithelial cells[Uncertain,Medium]
HPA:043010_11	0.0385430544849	0.571428571429	DKC1 GAR1 NOP10 YBX1	skin 1; Langerhans[Supported,Low]
HPA:050020_01	0.0390639780089	0.714285714286	YBX1 GAR1 DKC1 SHQ1 NOP10	spleen; cells in white pulp[Uncertain,Low]
GO:0006403	0.0400242316232	0.571428571429	DKC1 SHQ1 NAF1 NOP10	RNA localization
HPA:013020_12	0.0401346275679	0.571428571429	DKC1 GAR1 NOP10 YBX1	endometrium 1; glandular cells[Supported,Medium]
HP:0000704	0.0402984044053	0.285714285714	DKC1 NOP10	Periodontitis
HP:0001059	0.0402984044053	0.285714285714	DKC1 NOP10	Pterygium
HPA:028010_11	0.0415662981458	0.571428571429	DKC1 GAR1 NOP10 YBX1	lymph node; germinal center cells[Supported,Low]
HPA:007030_11	0.0443238877233	0.571428571429	DKC1 GAR1 NOP10 YBX1	cerebellum; cells in molecular layer[Supported,Low]
HPA:006020_11	0.0445414135224	0.571428571429	DKC1 GAR1 NOP10 YBX1	caudate; neuronal cells[Supported,Low]
HPA:016010_12	0.0445414135224	0.571428571429	DKC1 GAR1 NOP10 YBX1	esophagus; squamous epithelial cells[Supported,Medium]
HPA:044010_12	0.0449788087969	0.571428571429	DKC1 GAR1 NOP10 YBX1	skin 2; epidermal cells[Supported,Medium]
GO:0031330	0.0454459864488	0.571428571429	DKC1 YBX3 NAF1 YBX1	negative regulation of cellular catabolic process
HP:0002216	0.0465920925289	0.285714285714	DKC1 NOP10	Premature graying of hair
HPA:030010_02	0.0466084979646	0.714285714286	YBX1 GAR1 DKC1 SHQ1 NOP10	oral mucosa; squamous epithelial cells[Uncertain,Medium]
HPA:004020_12	0.0467598956995	0.571428571429	DKC1 GAR1 NOP10 YBX1	breast; glandular cells[Supported,Medium]
HPA:009010_11	0.0472131140888	0.571428571429	DKC1 GAR1 NOP10 YBX1	cervix, uterine; glandular cells[Supported,Low]
HPA:046010_11	0.0488247249262	0.571428571429	DKC1 GAR1 NOP10 YBX1	smooth muscle; smooth muscle cells[Supported,Low]
HPA:015010_12	0.0495275911524	0.571428571429	DKC1 GAR1 NOP10 YBX1	epididymis; glandular cells[Supported,Medium]
HPA:053020_12	0.0497635163456	0.571428571429	DKC1 GAR1 NOP10 YBX1	testis; cells in seminiferous ducts[Supported,Medium]
HPA:050010_11	0.0497635163456	0.571428571429	DKC1 GAR1 NOP10 YBX1	spleen; cells in red pulp[Supported,Low]
CORUM:2156	0.0499886427319	0.142857142857	YBX1	YBX1-AKT1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
GAR1	DKC1	1.0	0.949	hein_WMM bioplex (DKC1,GAR1) bioplex_WMM youn_WMM hein (GAR1) Malo fraction treiber_WMM
NOP10	GAR1	1.0	0.949	hein_WMM bioplex (GAR1) bioplex_WMM hein (GAR1) fraction treiber_WMM
NOP10	DKC1	1.0	0.949	hein_WMM bioplex (DKC1) bioplex_WMM gupta_WMM fraction treiber_WMM
DKC1	YBX1	1.0	0.949	hein_WMM bioplex (DKC1) bioplex_WMM gupta_WMM fraction treiber_WMM
GAR1	YBX1	0.996	0.927	bioplex (GAR1) bioplex_WMM fraction treiber_WMM
YBX1	YBX3	0.975	0.887	hein_WMM bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM
DKC1	YBX3	0.924	0.843	bioplex (DKC1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	SHQ1	0.886	0.817	hein_WMM bioplex (DKC1) bioplex_WMM
DKC1	NAF1	0.715	0.728	hein_WMM bioplex (DKC1) bioplex_WMM youn_WMM hein (NAF1) fraction
GAR1	YBX3	0.694	0.717	bioplex (GAR1) bioplex_WMM youn_WMM fraction treiber_WMM
NOP10	YBX1	0.029	0.232	hein_WMM bioplex_WMM gupta_WMM fraction treiber_WMM
SHQ1	NAF1	0.023	0.207	hein_WMM bioplex_WMM hein (NAF1)
GAR1	SHQ1	0.021	0.187	hein_WMM bioplex (GAR1) bioplex_WMM
NOP10	NAF1	0.018	0.176	hein_WMM bioplex_WMM hein (NAF1)
NOP10	SHQ1	0.009	0.09	hein_WMM bioplex_WMM WMM_only
NAF1	YBX3	0.007	0.003	bioplex_WMM youn_WMM WMM_only
SHQ1	YBX1	0.007	0.006	bioplex_WMM WMM_only
NOP10	YBX3	0.007	0.005	hein_WMM bioplex_WMM gupta_WMM WMM_only
SHQ1	YBX3	0.007	0.006	bioplex_WMM WMM_only
GAR1	NAF1	0.006	0.002	bioplex_WMM youn_WMM WMM_only
NAF1	YBX1	0.0	0.017	bioplex_WMM fraction

Images

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Complex HuMAP2_01695 has an average edge precision of 0.459 which is ranked 2807 out of all 6965 complexes.

Related Complexes

Genename	Complexes
YBX1	HuMAP2_01695 HuMAP2_02207 HuMAP2_04416
YBX3	HuMAP2_01695 HuMAP2_02631 HuMAP2_03425 HuMAP2_03637 HuMAP2_05476 HuMAP2_06751
NOP10	HuMAP2_00041 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_06551
DKC1	HuMAP2_00041 HuMAP2_00275 HuMAP2_00537 HuMAP2_01057 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_02076 HuMAP2_03262 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
GAR1	HuMAP2_00041 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_03262
SHQ1	HuMAP2_01164 HuMAP2_01695 HuMAP2_06089
NAF1	HuMAP2_01164 HuMAP2_01695 HuMAP2_02183 HuMAP2_03678 HuMAP2_06089

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_01695