hu.MAP 2.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Links
CIZ1	Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)	UniProt NCBI
PCGF6	Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)	UniProt NCBI
SERPINF1	Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1)	UniProt NCBI
MGA	MAX gene-associated protein (MAX dimerization protein 5)	UniProt NCBI
MSANTD2	Myb/SANT-like DNA-binding domain-containing protein 2	UniProt NCBI
TFDP1	Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1)	UniProt NCBI
L3MBTL2	Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)	UniProt NCBI
E2F6	Transcription factor E2F6 (E2F-6)	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1194	3.36019899504e-13	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	E2F-6 complex
REAC:R-HSA-8953750	4.50456749059e-10	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	Transcriptional Regulation by E2F6
GO:0070317	1.98894336804e-07	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	negative regulation of G0 to G1 transition
GO:0070316	2.28991321124e-07	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	regulation of G0 to G1 transition
GO:0045023	3.00089323888e-07	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	G0 to G1 transition
GO:0010948	0.00673460397389	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	negative regulation of cell cycle process
REAC:R-HSA-212436	0.0132859010078	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	Generic Transcription Pathway
REAC:R-HSA-69205	0.0168024726075	0.25	E2F6 TFDP1	G1/S-Specific Transcription
REAC:R-HSA-73857	0.0224473446481	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	RNA Polymerase II Transcription
REAC:R-HSA-74160	0.037866398773	0.625	L3MBTL2 MGA TFDP1 PCGF6 E2F6	Gene expression (Transcription)
CORUM:6588	0.0497224828424	0.125	TFDP1	E2F-1-DP-1 complex

Protein 1	Protein 2	Score	Precision	Evidence
L3MBTL2	E2F6	0.997	0.934	hein_WMM bioplex (E2F6,L3MBTL2) bioplex_WMM youn_WMM hein (L3MBTL2)
L3MBTL2	MGA	0.996	0.928	hein_WMM bioplex (L3MBTL2) bioplex_WMM youn_WMM hein (L3MBTL2)
PCGF6	MGA	0.988	0.902	hein_WMM bioplex (PCGF6) bioplex_WMM youn_WMM
PCGF6	L3MBTL2	0.978	0.893	hein_WMM bioplex (L3MBTL2,PCGF6) bioplex_WMM youn_WMM hein (L3MBTL2)
E2F6	MGA	0.912	0.835	hein_WMM bioplex (E2F6) bioplex_WMM youn_WMM
L3MBTL2	TFDP1	0.785	0.756	hein_WMM bioplex (L3MBTL2) bioplex_WMM youn_WMM hein (L3MBTL2)
PCGF6	E2F6	0.706	0.727	hein_WMM bioplex (E2F6,PCGF6) bioplex_WMM youn_WMM
E2F6	TFDP1	0.558	0.649	hein_WMM bioplex (E2F6) bioplex_WMM youn_WMM
PCGF6	TFDP1	0.256	0.479	hein_WMM bioplex (PCGF6) bioplex_WMM youn_WMM gupta_WMM
L3MBTL2	CIZ1	0.072	0.354	bioplex (L3MBTL2) bioplex_WMM youn_WMM
PCGF6	MSANTD2	0.063	0.346	youn_WMM bioplex () bioplex_WMM
L3MBTL2	SERPINF1	0.033	0.247	bioplex (SERPINF1) bioplex_WMM
TFDP1	MGA	0.013	0.141	hein_WMM bioplex_WMM youn_WMM WMM_only
PCGF6	CIZ1	0.008	0.035	bioplex_WMM youn_WMM gupta_WMM WMM_only
TFDP1	CIZ1	0.008	0.032	bioplex_WMM youn_WMM gupta_WMM WMM_only
E2F6	CIZ1	0.008	0.017	bioplex_WMM youn_WMM WMM_only
MSANTD2	MGA	0.008	0.014	youn_WMM WMM_only bioplex_WMM
MSANTD2	CIZ1	0.007	0.008	youn_WMM WMM_only
MSANTD2	E2F6	0.007	0.007	youn_WMM WMM_only
MSANTD2	TFDP1	0.007	0.005	youn_WMM WMM_only
CIZ1	MGA	0.007	0.003	bioplex_WMM youn_WMM WMM_only
L3MBTL2	MSANTD2	0.007	0.002	youn_WMM WMM_only

Click to enlarge

Complex HuMAP2_01696 has an average edge precision of 0.378 which is ranked 3547 out of all 6965 complexes.

Genename	Complexes
CIZ1	HuMAP2_01696 HuMAP2_03231 HuMAP2_05847
PCGF6	HuMAP2_00900 HuMAP2_01696 HuMAP2_01963 HuMAP2_02200 HuMAP2_02290 HuMAP2_02596 HuMAP2_06770
SERPINF1	HuMAP2_01696 HuMAP2_03231
MGA	HuMAP2_01696 HuMAP2_01963
MSANTD2	HuMAP2_01696 HuMAP2_02290 HuMAP2_06770
TFDP1	HuMAP2_01696 HuMAP2_01963 HuMAP2_05987
L3MBTL2	HuMAP2_01696 HuMAP2_01963 HuMAP2_03231 HuMAP2_05847
E2F6	HuMAP2_01696 HuMAP2_01963 HuMAP2_05987