hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01697
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BCL2L1 | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | UniProt NCBI |
| BAD | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | UniProt NCBI |
| BAX | Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) | UniProt NCBI |
| BCL2 | Apoptosis regulator Bcl-2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2447 | 1.11848345416e-09 | 1.0 | BCL2L1 BAX BCL2 BAD | Amyotrophic lateral sclerosis (ALS) |
| KEGG:05014 | 4.51588946805e-09 | 1.0 | BCL2L1 BAX BCL2 BAD | Amyotrophic lateral sclerosis (ALS) |
| WP:WP254 | 1.64924601505e-08 | 1.0 | BCL2L1 BAX BCL2 BAD | Apoptosis |
| KEGG:01524 | 1.8591044121e-08 | 1.0 | BCL2L1 BAX BCL2 BAD | Platinum drug resistance |
| KEGG:01521 | 2.07927164268e-08 | 1.0 | BCL2L1 BAX BCL2 BAD | EGFR tyrosine kinase inhibitor resistance |
| REAC:R-HSA-109606 | 2.08858653508e-08 | 1.0 | BCL2L1 BAX BCL2 BAD | Intrinsic Pathway for Apoptosis |
| WP:WP1772 | 2.52098579154e-08 | 1.0 | BCL2L1 BAX BCL2 BAD | Apoptosis Modulation and Signaling |
| REAC:R-HSA-111453 | 1.13404535396e-07 | 0.75 | BCL2L1 BCL2 BAD | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| KEGG:04210 | 1.7513076548e-07 | 1.0 | BCL2L1 BAX BCL2 BAD | Apoptosis |
| KEGG:05162 | 1.92779147039e-07 | 1.0 | BCL2L1 BAX BCL2 BAD | Measles |
| WP:WP3872 | 2.57005041727e-07 | 0.75 | BCL2L1 BAX BCL2 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| KEGG:04215 | 1.09102814336e-06 | 0.75 | BCL2L1 BAX BCL2 | Apoptosis - multiple species |
| KEGG:05170 | 1.14552974293e-06 | 1.0 | BCL2L1 BAX BCL2 BAD | Human immunodeficiency virus 1 infection |
| GO:0051400 | 1.45302402969e-06 | 0.75 | BCL2L1 BAX BCL2 | BH domain binding |
| GO:0051434 | 1.45302402969e-06 | 0.75 | BCL2L1 BAX BCL2 | BH3 domain binding |
| GO:2001244 | 2.00655931676e-06 | 1.0 | BCL2L1 BAX BCL2 BAD | positive regulation of intrinsic apoptotic signaling pathway |
| WP:WP286 | 2.58521566797e-06 | 0.75 | BCL2L1 BCL2 BAD | IL-3 Signaling Pathway |
| GO:0051881 | 2.73059518213e-06 | 1.0 | BCL2L1 BAX BCL2 BAD | regulation of mitochondrial membrane potential |
| WP:WP1971 | 2.77896659511e-06 | 0.75 | BAD BAX BCL2 | Integrated Cancer Pathway |
| REAC:R-HSA-109581 | 2.97418404602e-06 | 1.0 | BCL2L1 BAX BCL2 BAD | Apoptosis |
| GO:0001836 | 3.01065622645e-06 | 1.0 | BCL2L1 BAX BCL2 BAD | release of cytochrome c from mitochondria |
| REAC:R-HSA-5357801 | 3.19306292696e-06 | 1.0 | BCL2L1 BAX BCL2 BAD | Programmed Cell Death |
| WP:WP3611 | 3.65058316643e-06 | 0.75 | BCL2L1 BAX BCL2 | Photodynamic therapy-induced AP-1 survival signaling. |
| GO:0070513 | 7.26438828159e-06 | 0.75 | BCL2L1 BAX BCL2 | death domain binding |
| GO:0046902 | 1.03503048148e-05 | 1.0 | BCL2L1 BAX BCL2 BAD | regulation of mitochondrial membrane permeability |
| KEGG:04115 | 1.1177007069e-05 | 0.75 | BCL2L1 BAX BCL2 | p53 signaling pathway |
| WP:WP4216 | 1.28520696315e-05 | 0.75 | BAD BAX BCL2 | Chromosomal and microsatellite instability in colorectal cancer |
| WP:WP2034 | 1.4574337259e-05 | 0.75 | BCL2L1 BAX BAD | Leptin signaling pathway |
| WP:WP4298 | 1.51808339309e-05 | 0.75 | BCL2L1 BAX BCL2 | Viral Acute Myocarditis |
| KEGG:05168 | 1.52906522211e-05 | 1.0 | BCL2L1 BAX BCL2 BAD | Herpes simplex virus 1 infection |
| KEGG:05212 | 1.5327283042e-05 | 0.75 | BCL2L1 BAX BAD | Pancreatic cancer |
| GO:0090559 | 1.65167708578e-05 | 1.0 | BCL2L1 BAX BCL2 BAD | regulation of membrane permeability |
| KEGG:05220 | 1.7381246657e-05 | 0.75 | BCL2L1 BAX BAD | Chronic myeloid leukemia |
| WP:WP4263 | 2.06481472174e-05 | 0.75 | BCL2L1 BAX BAD | Pancreatic adenocarcinoma pathway |
| KEGG:05210 | 2.37359736806e-05 | 0.75 | BAD BAX BCL2 | Colorectal cancer |
| WP:WP231 | 2.46544135014e-05 | 0.75 | BCL2L1 BAX BAD | TNF alpha Signaling Pathway |
| REAC:R-HSA-844455 | 3.01639213985e-05 | 0.5 | BCL2L1 BCL2 | The NLRP1 inflammasome |
| WP:WP4658 | 3.10867203099e-05 | 0.75 | BCL2L1 BAX BCL2 | Small cell lung cancer |
| KEGG:01522 | 3.14744143419e-05 | 0.75 | BAD BAX BCL2 | Endocrine resistance |
| KEGG:05222 | 3.36411053102e-05 | 0.75 | BCL2L1 BAX BCL2 | Small cell lung cancer |
| KEGG:05200 | 3.47503918145e-05 | 1.0 | BCL2L1 BAX BCL2 BAD | Pathways in cancer |
| KEGG:05145 | 3.59048577419e-05 | 0.75 | BCL2L1 BCL2 BAD | Toxoplasmosis |
| WP:WP710 | 4.08802374395e-05 | 0.75 | BAD BAX BCL2 | DNA Damage Response (only ATM dependent) |
| KEGG:04722 | 5.31309720846e-05 | 0.75 | BAD BAX BCL2 | Neurotrophin signaling pathway |
| GO:0008637 | 6.52012849586e-05 | 1.0 | BCL2L1 BAX BCL2 BAD | apoptotic mitochondrial changes |
| KEGG:04140 | 0.000102469260232 | 0.75 | BCL2L1 BCL2 BAD | Autophagy - animal |
| WP:WP1984 | 0.000109181545021 | 0.75 | BAD BAX BCL2 | Integrated Breast Cancer Pathway |
| WP:WP4666 | 0.000111482542004 | 0.75 | BAD BAX BCL2 | Hepatitis B infection |
| GO:2001235 | 0.000130738130864 | 1.0 | BCL2L1 BAX BCL2 BAD | positive regulation of apoptotic signaling pathway |
| GO:0007006 | 0.000135718631087 | 1.0 | BCL2L1 BAX BCL2 BAD | mitochondrial membrane organization |
| GO:2001242 | 0.000140840088864 | 1.0 | BCL2L1 BAX BCL2 BAD | regulation of intrinsic apoptotic signaling pathway |
| KEGG:05152 | 0.000147252104815 | 0.75 | BAD BAX BCL2 | Tuberculosis |
| KEGG:05161 | 0.000162538377473 | 0.75 | BAD BAX BCL2 | Hepatitis B |
| KEGG:05225 | 0.000175500256423 | 0.75 | BCL2L1 BAX BAD | Hepatocellular carcinoma |
| GO:0005741 | 0.000214275729623 | 1.0 | BCL2L1 BAX BCL2 BAD | mitochondrial outer membrane |
| WP:WP1742 | 0.000228185108581 | 0.5 | BCL2 BAX | TP53 Network |
| WP:WP3287 | 0.000228185108581 | 0.5 | BCL2 BAX | Overview of nanoparticle effects |
| WP:WP3657 | 0.000256685249648 | 0.5 | BCL2L1 BCL2 | Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex |
| WP:WP2507 | 0.000286857812512 | 0.5 | BCL2 BAX | Nanomaterial induced apoptosis |
| GO:0031968 | 0.00029476632277 | 1.0 | BCL2L1 BAX BCL2 BAD | organelle outer membrane |
| GO:0019867 | 0.000303906363787 | 1.0 | BCL2L1 BAX BCL2 BAD | outer membrane |
| GO:0097191 | 0.000322822438103 | 1.0 | BCL2L1 BAX BCL2 BAD | extrinsic apoptotic signaling pathway |
| GO:0010821 | 0.000342608092204 | 1.0 | BCL2L1 BAX BCL2 BAD | regulation of mitochondrion organization |
| WP:WP205 | 0.000387405527127 | 0.5 | BCL2L1 BAD | IL-7 Signaling Pathway |
| WP:WP4172 | 0.000867148271367 | 0.75 | BCL2L1 BCL2 BAD | PI3K-Akt Signaling Pathway |
| WP:WP3981 | 0.000884625784373 | 0.5 | BAD BCL2 | miRNA regulation of prostate cancer signaling pathways |
| WP:WP3614 | 0.000884625784373 | 0.5 | BCL2L1 BAX | Photodynamic therapy-induced HIF-1 survival signaling |
| REAC:R-HSA-111447 | 0.00105460323216 | 0.5 | BAD BCL2 | Activation of BAD and translocation to mitochondria |
| WP:WP3941 | 0.00111543472224 | 0.5 | BAD BCL2 | Oxidative Damage |
| KEGG:04151 | 0.00118089914293 | 0.75 | BCL2L1 BCL2 BAD | PI3K-Akt signaling pathway |
| GO:0001844 | 0.00132566605022 | 0.75 | BAD BAX BCL2 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| WP:WP364 | 0.00144137960059 | 0.5 | BCL2L1 BAD | IL-6 signaling pathway |
| WP:WP4008 | 0.00151155524127 | 0.5 | BAD BCL2 | NO/cGMP/PKG mediated Neuroprotection |
| GO:0097193 | 0.00157802566628 | 1.0 | BCL2L1 BAX BCL2 BAD | intrinsic apoptotic signaling pathway |
| REAC:R-HSA-622312 | 0.00171688133139 | 0.5 | BCL2L1 BCL2 | Inflammasomes |
| GO:1901030 | 0.00197902980402 | 0.75 | BAD BAX BCL2 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| GO:0090199 | 0.00217043933003 | 0.75 | BCL2L1 BAX BAD | regulation of release of cytochrome c from mitochondria |
| GO:0006839 | 0.00249113752463 | 1.0 | BCL2L1 BAX BCL2 BAD | mitochondrial transport |
| WP:WP304 | 0.00257484178538 | 0.5 | BAD BCL2 | Kit receptor signaling pathway |
| GO:0038034 | 0.00281780772825 | 0.75 | BCL2L1 BAX BCL2 | signal transduction in absence of ligand |
| GO:0097192 | 0.00281780772825 | 0.75 | BCL2L1 BAX BCL2 | extrinsic apoptotic signaling pathway in absence of ligand |
| WP:WP4155 | 0.00316000321986 | 0.5 | BAD BAX | Endometrial cancer |
| KEGG:05213 | 0.00318211487745 | 0.5 | BAD BAX | Endometrial cancer |
| GO:1901028 | 0.00331394418715 | 0.75 | BAD BAX BCL2 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| WP:WP3303 | 0.0034749006715 | 0.5 | BAD BAX | RAC1/PAK1/p38/MMP2 Pathway |
| KEGG:05218 | 0.00376859643257 | 0.5 | BAD BAX | Melanoma |
| GO:2001233 | 0.00381401733339 | 1.0 | BCL2L1 BAX BCL2 BAD | regulation of apoptotic signaling pathway |
| GO:0042391 | 0.0038760338754 | 1.0 | BCL2L1 BAX BCL2 BAD | regulation of membrane potential |
| KEGG:05223 | 0.00401698930658 | 0.5 | BAD BAX | Non-small cell lung cancer |
| WP:WP4255 | 0.00403274972955 | 0.5 | BAD BAX | Non-small cell lung cancer |
| REAC:R-HSA-114452 | 0.00436320194063 | 0.5 | BAD BCL2 | Activation of BH3-only proteins |
| GO:0070059 | 0.00447413621813 | 0.75 | BCL2L1 BAX BCL2 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| GO:0051204 | 0.00480126971785 | 0.75 | BAD BAX BCL2 | protein insertion into mitochondrial membrane |
| KEGG:04064 | 0.00613079763587 | 0.5 | BCL2L1 BCL2 | NF-kappa B signaling pathway |
| GO:0097345 | 0.0062689516986 | 0.75 | BAD BAX BCL2 | mitochondrial outer membrane permeabilization |
| GO:1902110 | 0.00710332146687 | 0.75 | BAD BAX BCL2 | positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| KEGG:05215 | 0.00796156937098 | 0.5 | BAD BCL2 | Prostate cancer |
| GO:1902686 | 0.0080085486554 | 0.75 | BAD BAX BCL2 | mitochondrial outer membrane permeabilization involved in programmed cell death |
| KEGG:04933 | 0.00813974967686 | 0.5 | BCL2 BAX | AGE-RAGE signaling pathway in diabetic complications |
| WP:WP1438 | 0.00834051312505 | 0.25 | BCL2 | Influenza A virus infection |
| GO:1902108 | 0.00848863295691 | 0.75 | BAD BAX BCL2 | regulation of mitochondrial membrane permeability involved in apoptotic process |
| GO:0035794 | 0.00848863295691 | 0.75 | BAD BAX BCL2 | positive regulation of mitochondrial membrane permeability |
| GO:0051205 | 0.00848863295691 | 0.75 | BAD BAX BCL2 | protein insertion into membrane |
| GO:1905710 | 0.00898751047669 | 0.75 | BAD BAX BCL2 | positive regulation of membrane permeability |
| GO:0008625 | 0.0106004966657 | 0.75 | BCL2L1 BAX BCL2 | extrinsic apoptotic signaling pathway via death domain receptors |
| KEGG:04071 | 0.0116808588864 | 0.5 | BCL2 BAX | Sphingolipid signaling pathway |
| REAC:R-HSA-168643 | 0.0137933430055 | 0.5 | BCL2L1 BCL2 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:04630 | 0.014392043024 | 0.5 | BCL2L1 BCL2 | JAK-STAT signaling pathway |
| KEGG:05226 | 0.0168647432957 | 0.5 | BCL2 BAX | Gastric cancer |
| KEGG:05160 | 0.0181736572757 | 0.5 | BAD BAX | Hepatitis C |
| MIRNA:hsa-miR-184 | 0.0187858608682 | 0.5 | BCL2L1 BCL2 | hsa-miR-184 |
| WP:WP4223 | 0.0197782099748 | 0.5 | BCL2L1 BAD | Ras Signaling |
| GO:0008630 | 0.0198185309013 | 0.75 | BCL2L1 BAX BCL2 | intrinsic apoptotic signaling pathway in response to DNA damage |
| GO:0097190 | 0.0206423804985 | 1.0 | BCL2L1 BAX BCL2 BAD | apoptotic signaling pathway |
| KEGG:04217 | 0.0226863463099 | 0.5 | BCL2 BAX | Necroptosis |
| KEGG:04141 | 0.0241976216174 | 0.5 | BCL2 BAX | Protein processing in endoplasmic reticulum |
| KEGG:05202 | 0.0241976216174 | 0.5 | BCL2L1 BAX | Transcriptional misregulation in cancer |
| KEGG:04621 | 0.0245056398731 | 0.5 | BCL2L1 BCL2 | NOD-like receptor signaling pathway |
| CORUM:3492 | 0.0249595281251 | 0.25 | BAX | BAX homo-oligomer complex |
| CORUM:2000 | 0.0249595281251 | 0.25 | BAX | BAX homo-oligomer complex |
| GO:0043065 | 0.0272124122863 | 1.0 | BCL2L1 BAX BCL2 BAD | positive regulation of apoptotic process |
| GO:0043068 | 0.0288632862702 | 1.0 | BCL2L1 BAX BCL2 BAD | positive regulation of programmed cell death |
| WP:WP306 | 0.0290430519819 | 0.5 | BAD BCL2 | Focal Adhesion |
| KEGG:05169 | 0.0328286642151 | 0.5 | BCL2 BAX | Epstein-Barr virus infection |
| GO:0007005 | 0.0330068688285 | 1.0 | BCL2L1 BAX BCL2 BAD | mitochondrion organization |
| KEGG:04014 | 0.0331864260111 | 0.5 | BCL2L1 BAD | Ras signaling pathway |
| WP:WP4399 | 0.0333519728792 | 0.25 | BCL2 | MicroRNA network associated with chronic lymphocytic leukemia |
| KEGG:05203 | 0.03463652866 | 0.5 | BAD BAX | Viral carcinogenesis |
| KEGG:04510 | 0.0350038155474 | 0.5 | BAD BCL2 | Focal adhesion |
| KEGG:05166 | 0.0380105899241 | 0.5 | BCL2L1 BAX | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-6785807 | 0.0381968559025 | 0.5 | BCL2L1 BCL2 | Interleukin-4 and Interleukin-13 signaling |
| WP:WP3888 | 0.0393304030404 | 0.5 | BCL2L1 BCL2 | VEGFA-VEGFR2 Signaling Pathway |
| GO:0010942 | 0.0403998712414 | 1.0 | BCL2L1 BAX BCL2 BAD | positive regulation of cell death |
| GO:0097136 | 0.0405595771497 | 0.5 | BCL2L1 BAX | Bcl-2 family protein complex |
| WP:WP3672 | 0.0416857670091 | 0.25 | BCL2L1 | LncRNA-mediated mechanisms of therapeutic resistance |
| CORUM:5526 | 0.0499140284799 | 0.25 | BCL2 | CALM1-FKBP38-BCL2 complex |
| CORUM:5812 | 0.0499140284799 | 0.25 | BCL2L1 | p53-BCL2 complex |
| CORUM:7275 | 0.0499140284799 | 0.25 | BCL2 | BCL2-CISD2 complex |
| CORUM:1062 | 0.0499140284799 | 0.25 | BCL2 | BAR-BCL2-CASP8 complex |
| CORUM:5811 | 0.0499140284799 | 0.25 | BCL2 | p53-BCL2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BAD | BCL2L1 | 0.976 | 0.892 | bioplex (BCL2L1) bioplex_WMM |
| BAX | BCL2L1 | 0.939 | 0.85 | hein_WMM bioplex (BCL2L1) bioplex_WMM hein (BAX) |
| BCL2 | BCL2L1 | 0.831 | 0.778 | bioplex (BCL2L1) bioplex_WMM |
| BAX | BCL2 | 0.01 | 0.132 | bioplex_WMM WMM_only |
| BAD | BCL2 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| BAX | BAD | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01697 has an average edge precision of 0.472 which is ranked 2676 out of all 6965 complexes.
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