hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01706
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAGE3 | EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) | UniProt NCBI |
| TPRKB | EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein) | UniProt NCBI |
| TP53RK | EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) | UniProt NCBI |
| HYKK | Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) | UniProt NCBI |
| NFYB | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | UniProt NCBI |
| GON7 | EKC/KEOPS complex subunit GON7 | UniProt NCBI |
| OSGEP | Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP) | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7555 | 1.58119379133e-12 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | KEOPS complex |
| GO:0000408 | 2.75202561382e-12 | 0.625 | GON7 TP53RK OSGEP LAGE3 TPRKB | EKC/KEOPS complex |
| HP:0100720 | 1.60347078537e-08 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Hypoplasia of the ear cartilage |
| HP:0002410 | 5.33283819263e-08 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Aqueductal stenosis |
| HP:0002036 | 2.82959737375e-07 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Hiatus hernia |
| REAC:R-HSA-6782315 | 6.08392575302e-07 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | tRNA modification in the nucleus and cytosol |
| HP:0005108 | 9.13738934399e-07 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of the intervertebral disk |
| GO:0070525 | 1.21863779688e-06 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | tRNA threonylcarbamoyladenosine metabolic process |
| HP:0000096 | 5.55865351084e-06 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Glomerulosclerosis |
| HP:0003774 | 1.50143856476e-05 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Stage 5 chronic kidney disease |
| HP:0001181 | 1.59796109097e-05 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Adducted thumb |
| REAC:R-HSA-72306 | 2.51962917799e-05 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | tRNA processing |
| HP:0000601 | 2.99333731359e-05 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Hypotelorism |
| HP:0012622 | 3.49606707389e-05 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Chronic kidney disease |
| HP:0000112 | 4.91289434064e-05 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Nephropathy |
| HP:0001622 | 0.000117748499778 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Premature birth |
| HP:0000100 | 0.000117748499778 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Nephrotic syndrome |
| HP:0001302 | 0.000131503460926 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Pachygyria |
| HP:0000095 | 0.000212155398735 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of renal glomerulus morphology |
| HP:0031263 | 0.000212155398735 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal renal corpuscle morphology |
| HP:0001339 | 0.000240799653472 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Lissencephaly |
| CORUM:7556 | 0.000245118829946 | 0.25 | OSGEP LAGE3 | PRAME complex |
| HP:0000093 | 0.000297751302141 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Proteinuria |
| HP:0020129 | 0.000374523443078 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal urine protein level |
| HP:0011035 | 0.000406810175843 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal renal cortex morphology |
| HP:0100490 | 0.000529575451116 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Camptodactyly of finger |
| HP:0001220 | 0.000557110821358 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Interphalangeal joint contracture of finger |
| HP:0000400 | 0.000615368796977 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Macrotia |
| HP:0006261 | 0.000661954787282 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal phalangeal joint morphology of the hand |
| HP:0012575 | 0.000711120498183 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal nephron morphology |
| HP:0004374 | 0.000745376198503 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Hemiplegia/hemiparesis |
| HP:0012785 | 0.000762957953135 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Flexion contracture of finger |
| HP:0009473 | 0.00136564905571 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Joint contracture of the hand |
| REAC:R-HSA-8953854 | 0.00140831339051 | 0.625 | TPRKB GSPT2 TP53RK OSGEP LAGE3 | Metabolism of RNA |
| HP:0012385 | 0.00211126489589 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Camptodactyly |
| HP:0100360 | 0.00226671678974 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Contractures of the joints of the upper limbs |
| HP:0030044 | 0.00278436638923 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Flexion contracture of digit |
| HP:0002536 | 0.00383588648284 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal cortical gyration |
| HP:0001172 | 0.00395521203096 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal thumb morphology |
| HP:0000083 | 0.00569087806301 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Renal insufficiency |
| HP:0003121 | 0.00601368132246 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Limb joint contracture |
| HP:0002538 | 0.00643605663559 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of the cerebral cortex |
| HP:0002269 | 0.0100380518138 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of neuronal migration |
| HP:0001967 | 0.0109327161708 | 0.25 | OSGEP TP53RK | Diffuse mesangial sclerosis |
| GO:0002949 | 0.0126230555186 | 0.25 | TPRKB OSGEP | tRNA threonylcarbamoyladenosine modification |
| HP:0002353 | 0.0135486926517 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | EEG abnormality |
| HP:0010549 | 0.014473250933 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Weakness due to upper motor neuron dysfunction |
| HP:0030178 | 0.0162884350978 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of central nervous system electrophysiology |
| HP:0009810 | 0.0164614029727 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of upper limb joint |
| HP:0001966 | 0.0173789434513 | 0.25 | OSGEP TP53RK | Mesangial abnormality |
| HP:0100790 | 0.0188357237436 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Hernia |
| HP:0001511 | 0.0192222805697 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Intrauterine growth retardation |
| HP:0002577 | 0.0269816713634 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of the stomach |
| HP:0001311 | 0.0332028380473 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormal nervous system electrophysiology |
| HPA:050020_22 | 0.037550825165 | 0.625 | GON7 GSPT2 TP53RK LAGE3 TPRKB | spleen; cells in white pulp[Approved,Medium] |
| HP:0003110 | 0.0435399712974 | 0.5 | TPRKB TP53RK OSGEP LAGE3 | Abnormality of urine homeostasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAGE3 | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) fraction boldt_WMM |
| TP53RK | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP,TP53RK) bioplex_WMM boldt youn_WMM hein (OSGEP) boldt_WMM |
| TPRKB | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) boldt_WMM |
| GON7 | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM hein (OSGEP) |
| TP53RK | GON7 | 0.878 | 0.812 | hein_WMM bioplex (TP53RK) bioplex_WMM |
| TP53RK | TPRKB | 0.87 | 0.803 | hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM |
| TP53RK | LAGE3 | 0.55 | 0.643 | hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM |
| NFYB | LAGE3 | 0.043 | 0.269 | fraction |
| LAGE3 | GSPT2 | 0.028 | 0.231 | gupta_WMM fraction |
| OSGEP | HYKK | 0.025 | 0.212 | bioplex (OSGEP) bioplex_WMM |
| LAGE3 | TPRKB | 0.021 | 0.188 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TPRKB | GON7 | 0.013 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| LAGE3 | GON7 | 0.011 | 0.14 | hein_WMM bioplex_WMM WMM_only |
| GON7 | HYKK | 0.009 | 0.108 | bioplex_WMM WMM_only |
| TPRKB | HYKK | 0.008 | 0.092 | bioplex_WMM WMM_only |
| LAGE3 | HYKK | 0.008 | 0.066 | bioplex_WMM WMM_only |
| OSGEP | GSPT2 | 0.008 | 0.059 | fraction |
| TP53RK | HYKK | 0.007 | 0.005 | bioplex_WMM WMM_only |
| TPRKB | GSPT2 | 0.0 | 0.009 | fraction |
| NFYB | OSGEP | 0.0 | 0.004 | fraction |
| NFYB | GSPT2 | 0.0 | 0.0 | fraction |
Images
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Complex HuMAP2_01706 has an average edge precision of 0.361 which is ranked 3741 out of all 6965 complexes.
Related Complexes