hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01710
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKAP7 | A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) | UniProt NCBI |
| LSM1 | U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm) | UniProt NCBI |
| TUT1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | UniProt NCBI |
| PATL1 | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | UniProt NCBI |
| LSM10 | U7 snRNA-associated Sm-like protein LSm10 | UniProt NCBI |
| LSM6 | U6 snRNA-associated Sm-like protein LSm6 | UniProt NCBI |
| LSM5 | U6 snRNA-associated Sm-like protein LSm5 | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-430039 | 4.87697936989e-12 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | mRNA decay by 5' to 3' exoribonuclease |
| CORUM:561 | 5.53061082903e-11 | 0.5 | LSM4 LSM6 LSM1 LSM5 | LSm1-7 complex |
| REAC:R-HSA-429914 | 6.16088685852e-09 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | Deadenylation-dependent mRNA decay |
| KEGG:03018 | 8.05256076288e-09 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | RNA degradation |
| GO:0043928 | 1.083663195e-07 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | exonucleolytic catabolism of deadenylated mRNA |
| GO:0000291 | 1.48175348117e-07 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | nuclear-transcribed mRNA catabolic process, exonucleolytic |
| CORUM:562 | 1.64652925394e-07 | 0.375 | LSM6 LSM5 LSM4 | LSm2-8 complex |
| GO:0000288 | 5.49185841861e-06 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:0120114 | 7.30458044105e-06 | 0.625 | LSM4 LSM6 LSM5 LSM1 LSM10 | Sm-like protein family complex |
| REAC:R-HSA-8953854 | 3.16815271587e-05 | 0.75 | LSM5 LSM4 LSM6 LSM10 LSM1 PATL1 | Metabolism of RNA |
| GO:0120115 | 0.000177825159425 | 0.375 | LSM6 LSM5 LSM4 | Lsm2-8 complex |
| GO:0016071 | 0.000214774794186 | 0.875 | TUT1 LSM5 PATL1 LSM4 LSM6 LSM1 LSM10 | mRNA metabolic process |
| GO:0005688 | 0.00028444859377 | 0.375 | LSM6 LSM5 LSM4 | U6 snRNP |
| GO:0030532 | 0.0010043755339 | 0.5 | LSM4 LSM6 LSM10 LSM5 | small nuclear ribonucleoprotein complex |
| GO:0000956 | 0.0010433634795 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | nuclear-transcribed mRNA catabolic process |
| GO:0000932 | 0.00114109330922 | 0.5 | LSM4 LSM6 LSM1 PATL1 | P-body |
| KEGG:03040 | 0.00169432719911 | 0.375 | LSM6 LSM5 LSM4 | Spliceosome |
| GO:0006402 | 0.0152465526992 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | mRNA catabolic process |
| REAC:R-HSA-72163 | 0.0159464809698 | 0.375 | LSM6 LSM5 LSM4 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.0181710734818 | 0.375 | LSM6 LSM5 LSM4 | mRNA Splicing |
| GO:0097526 | 0.0205085054668 | 0.375 | LSM6 LSM5 LSM4 | spliceosomal tri-snRNP complex |
| GO:0046540 | 0.0205085054668 | 0.375 | LSM6 LSM5 LSM4 | U4/U6 x U5 tri-snRNP complex |
| GO:1990904 | 0.0210101725439 | 0.75 | LSM5 LSM4 LSM6 LSM10 LSM1 PATL1 | ribonucleoprotein complex |
| GO:0006401 | 0.0232909099363 | 0.625 | LSM4 LSM6 PATL1 LSM1 LSM5 | RNA catabolic process |
| GO:0003723 | 0.0270720656443 | 0.875 | TUT1 LSM5 PATL1 LSM4 LSM6 LSM1 LSM10 | RNA binding |
| GO:0006397 | 0.0348252240904 | 0.625 | LSM4 LSM6 LSM5 LSM1 TUT1 | mRNA processing |
| REAC:R-HSA-72203 | 0.0363175855426 | 0.375 | LSM6 LSM5 LSM4 | Processing of Capped Intron-Containing Pre-mRNA |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSM6 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM5 | PATL1 | 0.975 | 0.887 | bioplex (LSM5) bioplex_WMM youn_WMM |
| LSM6 | LSM1 | 0.634 | 0.684 | youn (LSM1) bioplex (LSM6) bioplex_WMM youn_WMM |
| LSM6 | PATL1 | 0.577 | 0.659 | youn (PATL1) bioplex (LSM6,PATL1) bioplex_WMM youn_WMM |
| LSM5 | LSM4 | 0.52 | 0.633 | youn (LSM4) bioplex (LSM5) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| LSM5 | LSM6 | 0.451 | 0.595 | bioplex (LSM5,LSM6) bioplex_WMM Guru youn_WMM fraction |
| LSM5 | LSM1 | 0.353 | 0.539 | bioplex (LSM5) bioplex_WMM youn_WMM |
| LSM6 | TUT1 | 0.195 | 0.449 | bioplex (LSM6) bioplex_WMM |
| LSM6 | AKAP7 | 0.158 | 0.416 | bioplex (LSM6) bioplex_WMM |
| LSM6 | LSM10 | 0.113 | 0.383 | bioplex (LSM6) bioplex_WMM youn_WMM |
| LSM4 | PATL1 | 0.107 | 0.373 | youn (LSM4,PATL1) bioplex (PATL1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| LSM5 | AKAP7 | 0.103 | 0.365 | bioplex (LSM5) bioplex_WMM |
| LSM4 | LSM1 | 0.09 | 0.355 | youn (LSM1,LSM4) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM treiber_WMM |
| LSM5 | TUT1 | 0.052 | 0.299 | bioplex (LSM5) bioplex_WMM |
| LSM1 | PATL1 | 0.03 | 0.236 | youn (LSM1,PATL1) bioplex_WMM boldt youn_WMM boldt_WMM |
| LSM4 | TUT1 | 0.026 | 0.216 | bioplex_WMM gupta_WMM WMM_only |
| AKAP7 | LSM4 | 0.017 | 0.168 | bioplex_WMM WMM_only |
| AKAP7 | TUT1 | 0.016 | 0.155 | bioplex_WMM WMM_only |
| AKAP7 | LSM1 | 0.012 | 0.144 | bioplex_WMM WMM_only |
| LSM1 | TUT1 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| LSM4 | LSM10 | 0.012 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| AKAP7 | LSM10 | 0.011 | 0.152 | bioplex_WMM WMM_only |
| TUT1 | LSM10 | 0.011 | 0.144 | bioplex_WMM WMM_only |
| LSM1 | LSM10 | 0.011 | 0.142 | youn (LSM1) bioplex_WMM youn_WMM |
| LSM5 | LSM10 | 0.009 | 0.107 | bioplex_WMM youn_WMM WMM_only |
| TUT1 | PATL1 | 0.009 | 0.097 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AKAP7 | PATL1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PATL1 | LSM10 | 0.008 | 0.045 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01710 has an average edge precision of 0.342 which is ranked 4096 out of all 6965 complexes.
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