hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01718
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TRAK2 | Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) | UniProt NCBI |
| TRAK1 | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | UniProt NCBI |
| RHOT1 | Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) | UniProt NCBI |
| GSK3B | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | UniProt NCBI |
| OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:177 | 1.35146690511e-09 | 0.6 | TRAK2 TRAK1 OGT | OGT-TRAK1-TRAK2 complex |
| GO:0034643 | 0.000412725169389 | 0.6 | TRAK2 TRAK1 RHOT1 | establishment of mitochondrion localization, microtubule-mediated |
| GO:0047497 | 0.000412725169389 | 0.6 | TRAK2 TRAK1 RHOT1 | mitochondrion transport along microtubule |
| GO:0051654 | 0.000616695699567 | 0.6 | TRAK2 TRAK1 RHOT1 | establishment of mitochondrion localization |
| GO:0051646 | 0.00367721278555 | 0.6 | TRAK2 TRAK1 RHOT1 | mitochondrion localization |
| GO:0098957 | 0.00450823411379 | 0.4 | TRAK2 TRAK1 | anterograde axonal transport of mitochondrion |
| MIRNA:hsa-miR-15a-5p | 0.00593236173589 | 0.8 | RHOT1 OGT GSK3B TRAK1 | hsa-miR-15a-5p |
| KEGG:04931 | 0.0218205669165 | 0.4 | GSK3B OGT | Insulin resistance |
| GO:0072384 | 0.0376065209581 | 0.6 | TRAK2 TRAK1 RHOT1 | organelle transport along microtubule |
| WP:WP3594 | 0.0426212197502 | 0.4 | GSK3B OGT | Circadian rhythm related genes |
| CORUM:0000000 | 0.0474603483533 | 1.0 | TRAK2 RHOT1 OGT GSK3B TRAK1 | CORUM root |
| CORUM:757 | 0.0499494897235 | 0.2 | GSK3B | Prune-GSK3beta complex |
| CORUM:5832 | 0.0499494897235 | 0.2 | TRAK1 | PINK1-MIRO2-Milton complex |
| CORUM:5836 | 0.0499494897235 | 0.2 | TRAK1 | MIRO2-Milton complex |
| CORUM:6248 | 0.0499494897235 | 0.2 | GSK3B | FBXW7-CSF3R-GSK3B complex |
| CORUM:7345 | 0.0499494897235 | 0.2 | TRAK1 | DISC1-TRAK1 complex |
| CORUM:7346 | 0.0499494897235 | 0.2 | RHOT1 | DISC1-RHOT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TRAK2 | TRAK1 | 0.991 | 0.909 | bioplex (TRAK2) bioplex_WMM |
| TRAK2 | GSK3B | 0.489 | 0.617 | bioplex (TRAK2) bioplex_WMM |
| TRAK2 | RHOT1 | 0.198 | 0.45 | bioplex (TRAK2) bioplex_WMM |
| TRAK2 | OGT | 0.154 | 0.415 | bioplex (TRAK2) bioplex_WMM gupta_WMM |
| TRAK1 | OGT | 0.008 | 0.067 | hein_WMM bioplex_WMM WMM_only |
| TRAK1 | GSK3B | 0.008 | 0.035 | bioplex_WMM WMM_only |
| TRAK1 | RHOT1 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| OGT | RHOT1 | 0.006 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| GSK3B | RHOT1 | 0.006 | 0.005 | bioplex_WMM youn_WMM WMM_only |
| GSK3B | OGT | 0.003 | 0.011 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_01718 has an average edge precision of 0.254 which is ranked 5323 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TRAK2 | HuMAP2_01016 HuMAP2_01718 HuMAP2_03894 HuMAP2_04384 |
| TRAK1 | HuMAP2_01016 HuMAP2_01718 HuMAP2_03894 HuMAP2_04384 |
| RHOT1 | HuMAP2_01718 HuMAP2_03894 HuMAP2_04384 HuMAP2_05277 |
| GSK3B | HuMAP2_01568 HuMAP2_01718 HuMAP2_04384 |
| OGT | HuMAP2_01718 HuMAP2_06679 |