hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01723
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NSL1 | Kinetochore-associated protein NSL1 homolog | UniProt NCBI |
| NDC80 | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | UniProt NCBI |
| DSN1 | Kinetochore-associated protein DSN1 homolog | UniProt NCBI |
| KNL1 | Kinetochore scaffold 1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | UniProt NCBI |
| SPC25 | Kinetochore protein Spc25 (hSpc25) | UniProt NCBI |
| NUF2 | Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1) | UniProt NCBI |
| SPC24 | Kinetochore protein Spc24 (hSpc24) | UniProt NCBI |
| MIS12 | Protein MIS12 homolog | UniProt NCBI |
| PMF1 | Polyamine-modulated factor 1 (PMF-1) | UniProt NCBI |
| PMF1 | Polyamine-modulated factor 1 (PMF-1) | UniProt NCBI |
| ZWINT | ZW10 interactor (ZW10-interacting protein 1) (Zwint-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-141424 | 1.02213782342e-20 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 1.02213782342e-20 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-69618 | 4.98084887899e-20 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 1.64530813776e-19 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 4.78318201809e-19 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | RHO GTPases Activate Formins |
| GO:0000776 | 7.2165418569e-18 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | kinetochore |
| REAC:R-HSA-2467813 | 1.28112311024e-17 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Separation of Sister Chromatids |
| REAC:R-HSA-68882 | 1.98629726643e-17 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Mitotic Anaphase |
| REAC:R-HSA-68877 | 1.98629726643e-17 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Mitotic Prometaphase |
| REAC:R-HSA-2555396 | 2.09543447888e-17 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Mitotic Metaphase and Anaphase |
| GO:0000775 | 1.55348436553e-16 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | chromosome, centromeric region |
| GO:0000777 | 2.19108872624e-16 | 0.8 | PMF1 SPC25 NDC80 DSN1 NUF2 KNL1 PMF1 MIS12 NSL1 | condensed chromosome kinetochore |
| REAC:R-HSA-69620 | 1.26395341491e-15 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Cell Cycle Checkpoints |
| GO:0000779 | 2.3007119597e-15 | 0.8 | PMF1 SPC25 NDC80 DSN1 NUF2 KNL1 PMF1 MIS12 NSL1 | condensed chromosome, centromeric region |
| REAC:R-HSA-195258 | 2.67578235798e-15 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | RHO GTPase Effectors |
| CORUM:7542 | 3.07197297078e-15 | 0.5 | MIS12 ZWINT SPC24 KNL1 NDC80 | KNL1-MIS12-NDC80-SPC24-ZWINT complex |
| CORUM:1464 | 1.84266796996e-14 | 0.5 | PMF1 DSN1 ZWINT PMF1 MIS12 NSL1 | Mis12 centromere complex |
| REAC:R-HSA-68886 | 2.0086519868e-14 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | M Phase |
| REAC:R-HSA-194315 | 7.5974479798e-14 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Signaling by Rho GTPases |
| GO:0098687 | 1.81703512743e-13 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | chromosomal region |
| REAC:R-HSA-69278 | 4.78805300306e-13 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 2.95031995123e-12 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Cell Cycle |
| CORUM:127 | 7.6236129225e-12 | 0.4 | NDC80 SPC25 NUF2 SPC24 | NDC80 kinetochore complex |
| GO:0000793 | 1.89669413688e-11 | 0.8 | PMF1 SPC25 NDC80 DSN1 NUF2 KNL1 PMF1 MIS12 NSL1 | condensed chromosome |
| GO:0007059 | 4.85671678292e-11 | 0.9 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 PMF1 MIS12 ZWINT NUF2 | chromosome segregation |
| GO:0000778 | 4.12246081009e-09 | 0.5 | PMF1 NDC80 NUF2 DSN1 PMF1 MIS12 | condensed nuclear chromosome kinetochore |
| GO:0000444 | 5.12306788392e-09 | 0.4 | MIS12 NSL1 PMF1 DSN1 PMF1 | MIS12/MIND type complex |
| GO:0031262 | 5.12306788392e-09 | 0.4 | NDC80 SPC25 NUF2 SPC24 | Ndc80 complex |
| GO:0031617 | 5.12306788392e-09 | 0.4 | NDC80 SPC25 NUF2 SPC24 | NMS complex |
| GO:0000780 | 1.7623227689e-08 | 0.5 | PMF1 NDC80 NUF2 DSN1 PMF1 MIS12 | condensed nuclear chromosome, centromeric region |
| REAC:R-HSA-162582 | 3.27668617525e-07 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | Signal Transduction |
| GO:0098813 | 5.24257774584e-07 | 0.7 | NDC80 DSN1 ZWINT KNL1 MIS12 NSL1 NUF2 | nuclear chromosome segregation |
| GO:0044427 | 6.73615720056e-07 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | chromosomal part |
| GO:0005694 | 9.68077631036e-07 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | chromosome |
| GO:0000070 | 6.03669958961e-06 | 0.6 | NDC80 DSN1 NSL1 MIS12 ZWINT NUF2 | mitotic sister chromatid segregation |
| GO:0000818 | 1.08982291228e-05 | 0.3 | MIS12 PMF1 DSN1 PMF1 | nuclear MIS12/MIND complex |
| GO:0000794 | 1.31467983658e-05 | 0.5 | PMF1 NDC80 NUF2 DSN1 PMF1 MIS12 | condensed nuclear chromosome |
| GO:0000819 | 1.70829420096e-05 | 0.6 | NDC80 DSN1 NSL1 MIS12 ZWINT NUF2 | sister chromatid segregation |
| CORUM:0000000 | 3.01031808081e-05 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | CORUM root |
| GO:0140014 | 0.000117096372866 | 0.6 | NDC80 DSN1 NSL1 MIS12 ZWINT NUF2 | mitotic nuclear division |
| GO:0008608 | 0.000207683806831 | 0.4 | MIS12 KNL1 NUF2 NDC80 | attachment of spindle microtubules to kinetochore |
| GO:0000280 | 0.000729675273802 | 0.6 | NDC80 DSN1 NSL1 MIS12 ZWINT NUF2 | nuclear division |
| GO:0048285 | 0.00143637627914 | 0.6 | NDC80 DSN1 NSL1 MIS12 ZWINT NUF2 | organelle fission |
| GO:0022402 | 0.00163992316578 | 0.8 | NDC80 SPC25 DSN1 NSL1 KNL1 MIS12 ZWINT NUF2 | cell cycle process |
| GO:1903047 | 0.00298880107881 | 0.7 | NDC80 SPC25 DSN1 NSL1 MIS12 ZWINT NUF2 | mitotic cell cycle process |
| GO:0051315 | 0.00310592047764 | 0.3 | MIS12 NUF2 NDC80 | attachment of mitotic spindle microtubules to kinetochore |
| GO:0051383 | 0.00493775244894 | 0.3 | MIS12 NUF2 NDC80 | kinetochore organization |
| GO:0007049 | 0.00632967942447 | 0.8 | NDC80 SPC25 DSN1 NSL1 KNL1 MIS12 ZWINT NUF2 | cell cycle |
| GO:0034501 | 0.00737429365883 | 0.3 | MIS12 KNL1 NDC80 | protein localization to kinetochore |
| GO:0000278 | 0.0085673537644 | 0.7 | NDC80 SPC25 DSN1 NSL1 MIS12 ZWINT NUF2 | mitotic cell cycle |
| MIRNA:hsa-miR-215-5p | 0.0142317491118 | 0.5 | PMF1 NUF2 DSN1 KNL1 PMF1 MIS12 | hsa-miR-215-5p |
| GO:0071459 | 0.0144029117203 | 0.3 | MIS12 KNL1 NDC80 | protein localization to chromosome, centromeric region |
| GO:0051276 | 0.0181227164942 | 0.7 | NDC80 DSN1 ZWINT KNL1 MIS12 NSL1 NUF2 | chromosome organization |
| GO:0043232 | 0.0298047658367 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | intracellular non-membrane-bounded organelle |
| GO:0043228 | 0.0299730351788 | 1.0 | PMF1 SPC25 NDC80 DSN1 NSL1 KNL1 SPC24 PMF1 MIS12 ZWINT NUF2 | non-membrane-bounded organelle |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DSN1 | NSL1 | 1.0 | 0.949 | hein_WMM bioplex (DSN1,NSL1) bioplex_WMM hein (DSN1) |
| SPC24 | NUF2 | 1.0 | 0.949 | hein_WMM bioplex (SPC24) bioplex_WMM hein (NUF2,SPC24) gupta_WMM |
| NDC80 | SPC24 | 1.0 | 0.949 | hein_WMM bioplex (SPC24) bioplex_WMM youn_WMM hein (SPC24) gupta_WMM |
| SPC25 | SPC24 | 1.0 | 0.949 | hein_WMM bioplex (SPC24,SPC25) bioplex_WMM hein (SPC24) gupta_WMM |
| MIS12 | NSL1 | 1.0 | 0.949 | hein_WMM bioplex (NSL1) bioplex_WMM hein (MIS12) gupta_WMM |
| MIS12 | DSN1 | 1.0 | 0.949 | hein_WMM bioplex (DSN1) bioplex_WMM hein (DSN1,MIS12) |
| MIS12 | SPC24 | 1.0 | 0.949 | hein_WMM bioplex (SPC24) bioplex_WMM hein (MIS12,SPC24) gupta_WMM |
| DSN1 | SPC24 | 1.0 | 0.949 | hein_WMM bioplex (DSN1,SPC24) bioplex_WMM youn_WMM hein (DSN1,SPC24) |
| DSN1 | SPC25 | 1.0 | 0.949 | hein_WMM bioplex (DSN1,SPC25) bioplex_WMM hein (DSN1) |
| DSN1 | KNL1 | 1.0 | 0.949 | hein_WMM bioplex (DSN1) bioplex_WMM youn_WMM hein (DSN1,KNL1) |
| NDC80 | DSN1 | 1.0 | 0.949 | hein_WMM bioplex (DSN1) bioplex_WMM hein (DSN1) |
| DSN1 | ZWINT | 1.0 | 0.949 | hein_WMM bioplex (DSN1,ZWINT) bioplex_WMM hein (DSN1,ZWINT) |
| MIS12 | SPC25 | 1.0 | 0.949 | hein_WMM bioplex (SPC25) bioplex_WMM hein (MIS12) |
| SPC25 | NUF2 | 0.999 | 0.949 | hein_WMM bioplex (SPC25) bioplex_WMM hein (NUF2) gupta_WMM fraction |
| KNL1 | NSL1 | 0.999 | 0.949 | hein_WMM bioplex (NSL1) bioplex_WMM hein (KNL1) gupta_WMM |
| KNL1 | SPC25 | 0.999 | 0.946 | hein_WMM bioplex (SPC25) bioplex_WMM hein (KNL1) |
| KNL1 | SPC24 | 0.999 | 0.945 | hein_WMM bioplex (SPC24) bioplex_WMM youn_WMM hein (KNL1,SPC24) gupta_WMM |
| KNL1 | ZWINT | 0.998 | 0.942 | hein_WMM bioplex (ZWINT) bioplex_WMM youn_WMM hein (KNL1,ZWINT) |
| DSN1 | NUF2 | 0.998 | 0.94 | hein_WMM bioplex (DSN1) bioplex_WMM hein (DSN1,NUF2) |
| SPC24 | NSL1 | 0.998 | 0.939 | hein_WMM bioplex (NSL1,SPC24) bioplex_WMM hein (SPC24) |
| NDC80 | ZWINT | 0.997 | 0.934 | hein_WMM bioplex (ZWINT) bioplex_WMM boldt hein (ZWINT) boldt_WMM |
| NSL1 | NUF2 | 0.997 | 0.93 | hein_WMM bioplex (NSL1) bioplex_WMM hein (NUF2) |
| NDC80 | SPC25 | 0.996 | 0.927 | hein_WMM bioplex (SPC25) bioplex_WMM gupta_WMM |
| DSN1 | PMF1 | 0.995 | 0.924 | bioplex (DSN1,PMF1) bioplex_WMM |
| SPC24 | ZWINT | 0.981 | 0.896 | hein_WMM bioplex (SPC24,ZWINT) bioplex_WMM youn_WMM hein (SPC24,ZWINT) |
| NDC80 | NUF2 | 0.975 | 0.887 | hein_WMM bioplex_WMM boldt hein (NDC80,NUF2) gupta_WMM boldt_WMM |
| PMF1 | NSL1 | 0.969 | 0.881 | bioplex (NSL1,PMF1) bioplex_WMM |
| ZWINT | NSL1 | 0.968 | 0.88 | hein_WMM bioplex (NSL1,ZWINT) bioplex_WMM hein (ZWINT) |
| SPC25 | ZWINT | 0.959 | 0.865 | hein_WMM bioplex (SPC25,ZWINT) bioplex_WMM hein (ZWINT) |
| SPC25 | NSL1 | 0.934 | 0.849 | hein_WMM bioplex (NSL1,SPC25) bioplex_WMM |
| SPC25 | PMF1 | 0.83 | 0.777 | bioplex (PMF1,SPC25) bioplex_WMM |
| ZWINT | NUF2 | 0.813 | 0.773 | hein_WMM bioplex (ZWINT) bioplex_WMM boldt hein (NUF2,ZWINT) boldt_WMM |
| MIS12 | ZWINT | 0.79 | 0.758 | hein_WMM bioplex (ZWINT) bioplex_WMM hein (MIS12,ZWINT) |
| MIS12 | NDC80 | 0.604 | 0.672 | hein_WMM bioplex_WMM hein (MIS12) gupta_WMM |
| MIS12 | KNL1 | 0.538 | 0.642 | hein_WMM bioplex_WMM hein (KNL1,MIS12) gupta_WMM |
| NDC80 | NSL1 | 0.5 | 0.621 | hein_WMM bioplex (NSL1) bioplex_WMM |
| PMF1 | SPC24 | 0.392 | 0.554 | bioplex (PMF1,SPC24) bioplex_WMM |
| NDC80 | KNL1 | 0.354 | 0.539 | hein_WMM bioplex_WMM youn_WMM hein (KNL1) gupta_WMM |
| MIS12 | PMF1 | 0.259 | 0.482 | hein_WMM hein (MIS12) gupta_WMM |
| MIS12 | PMF1 | 0.227 | 0.468 | bioplex (PMF1) bioplex_WMM |
| MIS12 | NUF2 | 0.165 | 0.42 | hein_WMM bioplex_WMM hein (MIS12,NUF2) |
| NDC80 | PMF1 | 0.164 | 0.42 | bioplex (PMF1) bioplex_WMM |
| KNL1 | NUF2 | 0.161 | 0.416 | hein_WMM bioplex_WMM youn_WMM hein (KNL1,NUF2) |
| KNL1 | PMF1 | 0.105 | 0.369 | bioplex (PMF1) bioplex_WMM |
| PMF1 | KNL1 | 0.077 | 0.354 | hein_WMM youn_WMM hein (KNL1) gupta_WMM |
| PMF1 | DSN1 | 0.067 | 0.35 | hein_WMM hein (DSN1) |
| PMF1 | NUF2 | 0.047 | 0.292 | bioplex (PMF1) bioplex_WMM |
| PMF1 | SPC24 | 0.021 | 0.188 | hein_WMM hein (SPC24) |
| PMF1 | ZWINT | 0.019 | 0.183 | hein_WMM hein (ZWINT) |
| PMF1 | NUF2 | 0.011 | 0.142 | hein_WMM hein (NUF2) |
| PMF1 | NSL1 | 0.01 | 0.112 | hein_WMM gupta_WMM WMM_only |
| PMF1 | SPC25 | 0.009 | 0.111 | hein_WMM WMM_only |
| NDC80 | PMF1 | 0.009 | 0.111 | hein_WMM WMM_only |
| PMF1 | ZWINT | 0.0 | 0.009 | bioplex (PMF1,ZWINT) bioplex_WMM |
Images
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Complex HuMAP2_01723 has an average edge precision of 0.698 which is ranked 1382 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NSL1 | HuMAP2_01723 HuMAP2_06403 HuMAP2_06889 |
| NDC80 | HuMAP2_01723 HuMAP2_03405 HuMAP2_06889 |
| DSN1 | HuMAP2_01723 HuMAP2_06403 HuMAP2_06889 |
| KNL1 | HuMAP2_01723 HuMAP2_06889 |
| SPC25 | HuMAP2_01723 HuMAP2_02111 HuMAP2_03405 HuMAP2_06889 |
| NUF2 | HuMAP2_01723 HuMAP2_03405 HuMAP2_06889 |
| SPC24 | HuMAP2_01723 HuMAP2_03405 HuMAP2_06889 |
| MIS12 | HuMAP2_01723 HuMAP2_06889 |
| PMF1 | HuMAP2_01723 |
| PMF1 | HuMAP2_01723 HuMAP2_02644 HuMAP2_04681 HuMAP2_05248 HuMAP2_06889 |
| ZWINT | HuMAP2_01723 HuMAP2_06889 |