hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01728
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTR9 | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | UniProt NCBI |
| CDC73 | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | UniProt NCBI |
| LEO1 | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | UniProt NCBI |
| PAF1 | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | UniProt NCBI |
| WDR61 | WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) (SKI8 homolog) (Ski8) [Cleaved into: WD repeat-containing protein 61, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1167 | 1.21903689317e-17 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | Paf complex |
| GO:0016593 | 4.58747963637e-13 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | Cdc73/Paf1 complex |
| GO:0032968 | 5.06916499819e-11 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | positive regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-8866654 | 9.36875968493e-11 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-75955 | 1.22790279228e-10 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 1.22790279228e-10 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-8852135 | 4.2331640377e-10 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | Protein ubiquitination |
| GO:0034243 | 6.6133434115e-10 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-674695 | 6.69220077371e-10 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | RNA Polymerase II Pre-transcription Events |
| GO:0032786 | 9.72832400388e-10 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | positive regulation of DNA-templated transcription, elongation |
| GO:0032784 | 1.12291179669e-08 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | regulation of DNA-templated transcription, elongation |
| GO:0001711 | 1.53650749201e-08 | 0.8 | LEO1 PAF1 CTR9 CDC73 | endodermal cell fate commitment |
| GO:0045638 | 1.56210562838e-08 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | negative regulation of myeloid cell differentiation |
| GO:0008023 | 1.73567292042e-08 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | transcription elongation factor complex |
| GO:0033523 | 6.03530623185e-08 | 0.8 | LEO1 PAF1 CTR9 CDC73 | histone H2B ubiquitination |
| GO:0016591 | 1.14617719967e-07 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | RNA polymerase II, holoenzyme |
| GO:0006368 | 1.84625698423e-07 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | transcription elongation from RNA polymerase II promoter |
| GO:0060795 | 2.21856478938e-07 | 0.8 | LEO1 PAF1 CTR9 CDC73 | cell fate commitment involved in formation of primary germ layer |
| GO:1903707 | 2.23519505842e-07 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | negative regulation of hemopoiesis |
| GO:0055029 | 5.00723926593e-07 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 5.27937183473e-07 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | DNA-directed RNA polymerase complex |
| GO:0030880 | 6.16749937273e-07 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | RNA polymerase complex |
| GO:0006354 | 7.91017852143e-07 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | DNA-templated transcription, elongation |
| WP:WP2853 | 8.42167978201e-07 | 0.8 | LEO1 PAF1 CTR9 CDC73 | Endoderm Differentiation |
| GO:0031440 | 1.82141275099e-06 | 0.8 | LEO1 PAF1 CTR9 CDC73 | regulation of mRNA 3'-end processing |
| GO:0010390 | 2.89320355875e-06 | 0.8 | LEO1 PAF1 CTR9 CDC73 | histone monoubiquitination |
| GO:0045637 | 5.3578971163e-06 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | regulation of myeloid cell differentiation |
| GO:0035987 | 7.17274954203e-06 | 0.8 | LEO1 PAF1 CTR9 CDC73 | endodermal cell differentiation |
| GO:0000993 | 8.04174090024e-06 | 0.8 | LEO1 PAF1 CTR9 CDC73 | RNA polymerase II complex binding |
| GO:0001706 | 8.98734431525e-06 | 0.8 | LEO1 PAF1 CTR9 CDC73 | endoderm formation |
| GO:0006378 | 1.11259903434e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | mRNA polyadenylation |
| GO:0043631 | 1.36251014669e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | RNA polyadenylation |
| GO:0007492 | 1.36251014669e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | endoderm development |
| GO:0016574 | 1.50217389985e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | histone ubiquitination |
| GO:0043175 | 1.50217389985e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | RNA polymerase core enzyme binding |
| GO:0001098 | 3.29372797631e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | basal transcription machinery binding |
| GO:0001099 | 3.29372797631e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | basal RNA polymerase II transcription machinery binding |
| GO:0061695 | 3.59850228871e-05 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | transferase complex, transferring phosphorus-containing groups |
| GO:0030099 | 4.39342287116e-05 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | myeloid cell differentiation |
| GO:0070063 | 4.8045251566e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | RNA polymerase binding |
| GO:0006513 | 5.53512234664e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | protein monoubiquitination |
| GO:0002683 | 6.02558366595e-05 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | negative regulation of immune system process |
| GO:0001704 | 6.3459788413e-05 | 0.8 | LEO1 PAF1 CTR9 CDC73 | formation of primary germ layer |
| GO:0031442 | 0.000108905457596 | 0.6 | LEO1 PAF1 CDC73 | positive regulation of mRNA 3'-end processing |
| GO:1903706 | 0.000155109589057 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | regulation of hemopoiesis |
| GO:0016570 | 0.000239991949727 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | histone modification |
| GO:0007369 | 0.000270299027917 | 0.8 | LEO1 PAF1 CTR9 CDC73 | gastrulation |
| GO:0016569 | 0.000301140640782 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | covalent chromatin modification |
| GO:0031124 | 0.000354439891603 | 0.8 | LEO1 PAF1 CTR9 CDC73 | mRNA 3'-end processing |
| GO:0045596 | 0.000401423752571 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | negative regulation of cell differentiation |
| REAC:R-HSA-73857 | 0.000412889072144 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | RNA Polymerase II Transcription |
| REAC:R-HSA-597592 | 0.000641406598892 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | Post-translational protein modification |
| REAC:R-HSA-74160 | 0.000713316403356 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | Gene expression (Transcription) |
| GO:0045165 | 0.000838244988417 | 0.8 | LEO1 PAF1 CTR9 CDC73 | cell fate commitment |
| GO:0050684 | 0.00102973750092 | 0.8 | LEO1 PAF1 CTR9 CDC73 | regulation of mRNA processing |
| GO:0035327 | 0.00139593056214 | 0.6 | PAF1 CTR9 WDR61 | transcriptionally active chromatin |
| GO:0031123 | 0.00155534683144 | 0.8 | LEO1 PAF1 CTR9 CDC73 | RNA 3'-end processing |
| GO:0030097 | 0.00177594994385 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | hemopoiesis |
| GO:0048534 | 0.00200830987068 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | hematopoietic or lymphoid organ development |
| GO:0050685 | 0.00208420080219 | 0.6 | LEO1 PAF1 CDC73 | positive regulation of mRNA processing |
| GO:0051093 | 0.00211202416883 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | negative regulation of developmental process |
| GO:0002520 | 0.00274868991294 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | immune system development |
| GO:0031062 | 0.00367721278555 | 0.6 | PAF1 CTR9 WDR61 | positive regulation of histone methylation |
| REAC:R-HSA-392499 | 0.0039377533293 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | Metabolism of proteins |
| GO:0016567 | 0.00400049209339 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | protein ubiquitination |
| GO:0006325 | 0.00448062284804 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | chromatin organization |
| GO:2001160 | 0.00450823411379 | 0.4 | CTR9 WDR61 | regulation of histone H3-K79 methylation |
| GO:2001162 | 0.00450823411379 | 0.4 | CTR9 WDR61 | positive regulation of histone H3-K79 methylation |
| GO:0032446 | 0.00732992354676 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | protein modification by small protein conjugation |
| GO:0051241 | 0.0088113073056 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | negative regulation of multicellular organismal process |
| GO:0031060 | 0.0111628079368 | 0.6 | PAF1 CTR9 WDR61 | regulation of histone methylation |
| GO:1990234 | 0.0112296002627 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | transferase complex |
| GO:0016071 | 0.0124036237668 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | mRNA metabolic process |
| GO:0034729 | 0.0135228859698 | 0.4 | CTR9 WDR61 | histone H3-K79 methylation |
| GO:0048598 | 0.0154362793345 | 0.8 | LEO1 PAF1 CTR9 CDC73 | embryonic morphogenesis |
| GO:0045944 | 0.0197094416222 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | positive regulation of transcription by RNA polymerase II |
| GO:0070647 | 0.023802724014 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | protein modification by small protein conjugation or removal |
| GO:1903311 | 0.0327910140884 | 0.8 | LEO1 PAF1 CTR9 CDC73 | regulation of mRNA metabolic process |
| GO:1903313 | 0.0358473364726 | 0.6 | LEO1 PAF1 CDC73 | positive regulation of mRNA metabolic process |
| GO:0031058 | 0.0376065209581 | 0.6 | PAF1 CTR9 WDR61 | positive regulation of histone modification |
| GO:0044451 | 0.0442638282809 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | nucleoplasm part |
| GO:0051276 | 0.046479053704 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | chromosome organization |
| CORUM:0000000 | 0.0474603483533 | 1.0 | LEO1 PAF1 CDC73 CTR9 WDR61 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LEO1 | CDC73 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,LEO1) Malo fraction boldt_WMM |
| PAF1 | CTR9 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9) Malo fraction boldt_WMM |
| PAF1 | CDC73 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73) Malo fraction boldt_WMM |
| CDC73 | WDR61 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,WDR61) Malo fraction boldt_WMM |
| CDC73 | CTR9 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,CTR9) Malo fraction boldt_WMM |
| LEO1 | CTR9 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9,LEO1) Malo fraction boldt_WMM |
| PAF1 | WDR61 | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (WDR61) Malo fraction boldt_WMM |
| LEO1 | PAF1 | 0.998 | 0.945 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LEO1) Malo fraction boldt_WMM |
| LEO1 | WDR61 | 0.997 | 0.929 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LEO1,WDR61) Malo fraction boldt_WMM |
| WDR61 | CTR9 | 0.988 | 0.901 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9) Malo fraction boldt_WMM |
Images
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Complex HuMAP2_01728 has an average edge precision of 0.942 which is ranked 382 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTR9 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_06434 |
| CDC73 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117 |
| LEO1 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117 |
| PAF1 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_06434 |
| WDR61 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 |