hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01745
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBAP1 | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | UniProt NCBI |
| VPS37A | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | UniProt NCBI |
| VPS28 | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-174490 | 1.63653275606e-07 | 1.0 | UBAP1 VPS28 VPS37A | Membrane binding and targetting of GAG proteins |
| REAC:R-HSA-174495 | 1.63653275606e-07 | 1.0 | UBAP1 VPS28 VPS37A | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| REAC:R-HSA-175474 | 2.51774270163e-07 | 1.0 | UBAP1 VPS28 VPS37A | Assembly Of The HIV Virion |
| REAC:R-HSA-9615710 | 1.31507096469e-06 | 1.0 | UBAP1 VPS28 VPS37A | Microautophagy |
| REAC:R-HSA-162588 | 1.47287948045e-06 | 1.0 | UBAP1 VPS28 VPS37A | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 2.02093811497e-06 | 1.0 | UBAP1 VPS28 VPS37A | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0000813 | 7.62876038594e-06 | 1.0 | UBAP1 VPS28 VPS37A | ESCRT I complex |
| REAC:R-HSA-9612973 | 7.95116633082e-05 | 1.0 | UBAP1 VPS28 VPS37A | Autophagy |
| GO:0043162 | 0.000103533176666 | 1.0 | UBAP1 VPS28 VPS37A | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| REAC:R-HSA-162599 | 0.00017233319357 | 1.0 | UBAP1 VPS28 VPS37A | Late Phase of HIV Life Cycle |
| GO:0036452 | 0.000208882724853 | 1.0 | UBAP1 VPS28 VPS37A | ESCRT complex |
| REAC:R-HSA-162587 | 0.000228431198544 | 1.0 | UBAP1 VPS28 VPS37A | HIV Life Cycle |
| REAC:R-HSA-162906 | 0.000819826928908 | 1.0 | UBAP1 VPS28 VPS37A | HIV Infection |
| GO:0075733 | 0.00225266395968 | 1.0 | UBAP1 VPS28 VPS37A | intracellular transport of virus |
| GO:0046794 | 0.00265735153444 | 1.0 | UBAP1 VPS28 VPS37A | transport of virus |
| REAC:R-HSA-5663205 | 0.00340936351327 | 1.0 | UBAP1 VPS28 VPS37A | Infectious disease |
| GO:0044766 | 0.00475834847216 | 1.0 | UBAP1 VPS28 VPS37A | multi-organism transport |
| GO:1902579 | 0.00475834847216 | 1.0 | UBAP1 VPS28 VPS37A | multi-organism localization |
| KEGG:04144 | 0.0117748506163 | 0.666666666667 | VPS28 VPS37A | Endocytosis |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | UBAP1 VPS28 VPS37A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | UBAP1 VPS28 VPS37A | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS28 | VPS37A | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM hein (VPS28) |
| VPS28 | UBAP1 | 1.0 | 0.949 | hein_WMM bioplex (UBAP1,VPS28) bioplex_WMM hein (VPS28) |
| UBAP1 | VPS37A | 0.919 | 0.841 | hein_WMM bioplex (UBAP1) bioplex_WMM youn_WMM |
Images
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Complex HuMAP2_01745 has an average edge precision of 0.913 which is ranked 501 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UBAP1 | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS37A | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS28 | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |