hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01746
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAPGEF5 | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) | UniProt NCBI |
| CHL1 | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | UniProt NCBI |
| ANK2 | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | UniProt NCBI |
| ANK1 | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | UniProt NCBI |
| FPGS | Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) | UniProt NCBI |
| COX5B | Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) | UniProt NCBI |
| ANK3 | Ankyrin-3 (ANK-3) (Ankyrin-G) | UniProt NCBI |
| HMGCL | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-373760 | 3.54406490439e-05 | 0.5 | ANK1 ANK2 ANK3 CHL1 | L1CAM interactions |
| REAC:R-HSA-445095 | 6.54691799565e-05 | 0.375 | ANK1 ANK3 ANK2 | Interaction between L1 and Ankyrins |
| REAC:R-HSA-447041 | 0.00125133439335 | 0.25 | CHL1 ANK1 | CHL1 interactions |
| GO:0043194 | 0.00184612317041 | 0.375 | ANK1 ANK3 ANK2 | axon initial segment |
| REAC:R-HSA-6807878 | 0.00259674522301 | 0.375 | ANK1 ANK3 ANK2 | COPI-mediated anterograde transport |
| KEGG:05205 | 0.00508611305093 | 0.375 | ANK1 ANK3 ANK2 | Proteoglycans in cancer |
| GO:0030507 | 0.00673356194115 | 0.375 | ANK1 ANK3 ANK2 | spectrin binding |
| REAC:R-HSA-199977 | 0.0084817691389 | 0.375 | ANK1 ANK3 ANK2 | ER to Golgi Anterograde Transport |
| WP:WP4148 | 0.00986432600459 | 0.25 | ANK3 CHL1 | Splicing factor NOVA regulated synaptic proteins |
| REAC:R-HSA-948021 | 0.0136666479669 | 0.375 | ANK1 ANK3 ANK2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-422475 | 0.0154610990555 | 0.5 | ANK1 ANK2 ANK3 CHL1 | Axon guidance |
| GO:0044304 | 0.0330194726961 | 0.375 | ANK1 ANK3 ANK2 | main axon |
| CORUM:6618 | 0.0497224828424 | 0.125 | ANK3 | RhBG-kAE1-ankyrin-G complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| 114299 | ANK3 | 0.996 | 0.927 | bioplex (114299) bioplex_WMM youn_WMM gupta_WMM |
| 114299 | FPGS | 0.927 | 0.844 | bioplex (114299) bioplex_WMM |
| ANK3 | RAPGEF5 | 0.602 | 0.67 | bioplex (RAPGEF5) bioplex_WMM |
| 114299 | ANK2 | 0.5 | 0.621 | bioplex (114299) bioplex_WMM |
| RAPGEF5 | ANK1 | 0.254 | 0.478 | bioplex (RAPGEF5) bioplex_WMM |
| RAPGEF5 | ANK2 | 0.091 | 0.355 | bioplex (RAPGEF5) bioplex_WMM |
| ANK3 | CHL1 | 0.047 | 0.29 | bioplex (CHL1) bioplex_WMM |
| ANK2 | CHL1 | 0.03 | 0.236 | bioplex (CHL1) bioplex_WMM |
| HMGCL | FPGS | 0.028 | 0.228 | bioplex (HMGCL) bioplex_WMM |
| ANK1 | CHL1 | 0.027 | 0.225 | bioplex (CHL1) bioplex_WMM |
| HMGCL | COX5B | 0.025 | 0.211 | bioplex (HMGCL) fraction |
| ANK3 | ANK2 | 0.012 | 0.15 | bioplex_WMM youn_WMM WMM_only |
| ANK3 | ANK1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ANK2 | ANK1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| ANK3 | FPGS | 0.008 | 0.013 | bioplex_WMM WMM_only |
| ANK2 | FPGS | 0.007 | 0.011 | bioplex_WMM WMM_only |
| ANK2 | COX5B | 0.007 | 0.001 | bioplex_WMM WMM_only |
| FPGS | COX5B | 0.007 | 0.005 | bioplex_WMM WMM_only |
| ANK3 | COX5B | 0.007 | 0.002 | bioplex_WMM WMM_only |
| ANK1 | COX5B | 0.006 | 0.009 | bioplex (ANK1) |
Images
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Complex HuMAP2_01746 has an average edge precision of 0.273 which is ranked 4988 out of all 6965 complexes.
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