hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01754
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PER2 | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | UniProt NCBI |
| CSNK1D | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | UniProt NCBI |
| RPS4Y2 | 40S ribosomal protein S4, Y isoform 2 (Small ribosomal subunit protein eS4) | UniProt NCBI |
| FAM110B | Protein FAM110B | UniProt NCBI |
| CSNK1E | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3298 | 3.01539944338e-06 | 0.6 | CSNK1E CSNK1D PER2 | Melatonin metabolism and effects |
| KEGG:04710 | 3.15221459068e-06 | 0.6 | CSNK1E CSNK1D PER2 | Circadian rhythm |
| REAC:R-HSA-400253 | 0.000118030564163 | 0.6 | CSNK1E CSNK1D PER2 | Circadian Clock |
| HP:0031873 | 0.000139411195565 | 0.4 | PER2 CSNK1D | Early chronotype |
| WP:WP3594 | 0.00046043508805 | 0.6 | CSNK1E CSNK1D PER2 | Circadian rhythm related genes |
| HP:0006979 | 0.00167158658755 | 0.4 | PER2 CSNK1D | Sleep-wake cycle disturbance |
| WP:WP4249 | 0.00233629086428 | 0.4 | CSNK1E CSNK1D | Hedgehog Signaling Pathway |
| REAC:R-HSA-6791226 | 0.00259573944873 | 0.6 | CSNK1E CSNK1D RPS4Y2 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.00304975168622 | 0.6 | CSNK1E CSNK1D RPS4Y2 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.00355347569673 | 0.6 | CSNK1E CSNK1D RPS4Y2 | rRNA processing |
| WP:WP363 | 0.00390244145107 | 0.4 | CSNK1E CSNK1D | Wnt Signaling Pathway |
| KEGG:04340 | 0.00403884103568 | 0.4 | CSNK1E CSNK1D | Hedgehog signaling pathway |
| GO:1905426 | 0.00450823411379 | 0.4 | CSNK1E CSNK1D | positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1905424 | 0.00450823411379 | 0.4 | CSNK1E CSNK1D | regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1904958 | 0.00450823411379 | 0.4 | CSNK1E CSNK1D | positive regulation of midbrain dopaminergic neuron differentiation |
| GO:1904956 | 0.00450823411379 | 0.4 | CSNK1E CSNK1D | regulation of midbrain dopaminergic neuron differentiation |
| GO:1904340 | 0.0135228859698 | 0.4 | CSNK1E CSNK1D | positive regulation of dopaminergic neuron differentiation |
| GO:0032922 | 0.0250406933376 | 0.6 | CSNK1E CSNK1D PER2 | circadian regulation of gene expression |
| MIRNA:hsa-miR-6772-3p | 0.0270575118475 | 0.4 | CSNK1E CSNK1D | hsa-miR-6772-3p |
| REAC:R-HSA-380284 | 0.0295837500362 | 0.4 | CSNK1E CSNK1D | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-380259 | 0.0295837500362 | 0.4 | CSNK1E CSNK1D | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-8854518 | 0.0323002764482 | 0.4 | CSNK1E CSNK1D | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 0.0411580285567 | 0.4 | CSNK1E CSNK1D | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.0411580285567 | 0.4 | CSNK1E CSNK1D | Centrosome maturation |
| KEGG:04390 | 0.0421802717446 | 0.4 | CSNK1E CSNK1D | Hippo signaling pathway |
| REAC:R-HSA-2565942 | 0.0465369402216 | 0.4 | CSNK1E CSNK1D | Regulation of PLK1 Activity at G2/M Transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK1E | CSNK1D | 0.975 | 0.887 | hein_WMM bioplex (CSNK1E) bioplex_WMM hein (CSNK1D) |
| FAM110B | CSNK1D | 0.448 | 0.592 | bioplex (CSNK1D) bioplex_WMM |
| CSNK1E | RPS4Y2 | 0.207 | 0.455 | bioplex (CSNK1E) bioplex_WMM |
| PER2 | CSNK1E | 0.136 | 0.407 | bioplex (CSNK1E) bioplex_WMM |
| PER2 | CSNK1D | 0.092 | 0.356 | bioplex (CSNK1D) bioplex_WMM |
| FAM110B | CSNK1E | 0.089 | 0.356 | bioplex (CSNK1E) bioplex_WMM |
| FAM110B | PER2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| PER2 | RPS4Y2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| FAM110B | RPS4Y2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CSNK1D | RPS4Y2 | 0.008 | 0.038 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01754 has an average edge precision of 0.34 which is ranked 4120 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PER2 | HuMAP2_00180 HuMAP2_01754 HuMAP2_03490 |
| CSNK1D | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |
| RPS4Y2 | HuMAP2_01754 HuMAP2_04344 |
| FAM110B | HuMAP2_00180 HuMAP2_01754 HuMAP2_03490 |
| CSNK1E | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |