hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01759
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KIF5B | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | UniProt NCBI |
| KLC1 | Kinesin light chain 1 (KLC 1) | UniProt NCBI |
| KIF5C | Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) | UniProt NCBI |
| KLC3 | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | UniProt NCBI |
| SYNE4 | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | UniProt NCBI |
| KLC4 | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | UniProt NCBI |
| KLC2 | Kinesin light chain 2 (KLC 2) | UniProt NCBI |
| FZD6 | Frizzled-6 (Fz-6) (hFz6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5625970 | 7.50808861849e-13 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | RHO GTPases activate KTN1 |
| REAC:R-HSA-983189 | 6.75214282855e-09 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Kinesins |
| REAC:R-HSA-6811434 | 9.79230638132e-08 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-2132295 | 2.56083935255e-07 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | MHC class II antigen presentation |
| REAC:R-HSA-8856688 | 4.55947799744e-07 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Golgi-to-ER retrograde transport |
| KEGG:05132 | 1.24161539819e-06 | 0.5 | KLC2 KLC1 KLC3 KLC4 | Salmonella infection |
| REAC:R-HSA-983231 | 1.25972993285e-06 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-6811442 | 3.69987049467e-06 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-195258 | 3.51126368389e-05 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | RHO GTPase Effectors |
| REAC:R-HSA-194315 | 0.000181135963543 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Signaling by Rho GTPases |
| GO:0005871 | 0.000329151443785 | 0.5 | KLC2 KIF5B KIF5C KLC1 | kinesin complex |
| REAC:R-HSA-109582 | 0.000537732785686 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Hemostasis |
| REAC:R-HSA-199991 | 0.000799602221976 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0010405888662 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Vesicle-mediated transport |
| REAC:R-HSA-1280218 | 0.00136646026541 | 0.625 | KLC2 KLC4 KIF5B KLC3 KLC1 | Adaptive Immune System |
| WP:WP4535 | 0.0119507998541 | 0.25 | KIF5B SYNE4 | Envelope proteins and their potential roles in EDMD physiopathology |
| REAC:R-HSA-264876 | 0.0122816673814 | 0.25 | KIF5C KIF5B | Insulin processing |
| REAC:R-HSA-162582 | 0.020478873125 | 0.75 | KLC2 KLC4 FZD6 KLC3 KIF5B KLC1 | Signal Transduction |
| GO:0005875 | 0.0213219858369 | 0.5 | KLC2 KIF5B KIF5C KLC1 | microtubule associated complex |
| CORUM:5401 | 0.0497224828424 | 0.125 | KIF5B | PLEKHM2-KIF5B complex |
| CORUM:6552 | 0.0497224828424 | 0.125 | KIF5B | KIF5B-SPG33 complex |
| CORUM:6554 | 0.0497224828424 | 0.125 | KIF5C | KIF5C-SPG33 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SYNE4 | KLC1 | 1.0 | 0.949 | bioplex (SYNE4) bioplex_WMM |
| SYNE4 | KLC3 | 1.0 | 0.949 | bioplex (SYNE4) bioplex_WMM |
| KIF5B | KLC2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (KIF5B,KLC2) gupta_WMM fraction boldt_WMM treiber_WMM |
| KLC1 | KLC2 | 1.0 | 0.949 | hein_WMM bioplex (KLC1) bioplex_WMM boldt youn_WMM hein (KLC1,KLC2) gupta_WMM boldt_WMM |
| KLC1 | KLC4 | 0.998 | 0.939 | hein_WMM bioplex (KLC1) bioplex_WMM boldt youn_WMM hein (KLC1,KLC4) gupta_WMM boldt_WMM |
| SYNE4 | KLC2 | 0.918 | 0.841 | bioplex (SYNE4) bioplex_WMM |
| KIF5B | KLC4 | 0.916 | 0.839 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (KIF5B,KLC4) gupta_WMM fraction boldt_WMM treiber_WMM |
| KLC1 | KLC3 | 0.84 | 0.784 | hein_WMM bioplex (KLC1) bioplex_WMM boldt youn_WMM boldt_WMM |
| SYNE4 | KLC4 | 0.71 | 0.729 | bioplex (SYNE4) bioplex_WMM |
| KLC2 | KLC4 | 0.636 | 0.684 | hein_WMM bioplex_WMM boldt youn_WMM hein (KLC2,KLC4) gupta_WMM boldt_WMM treiber_WMM |
| KLC2 | KLC3 | 0.288 | 0.489 | hein_WMM bioplex_WMM boldt youn_WMM hein (KLC3) boldt_WMM |
| SYNE4 | KIF5C | 0.283 | 0.488 | bioplex (SYNE4) bioplex_WMM |
| SYNE4 | KIF5B | 0.192 | 0.446 | bioplex (SYNE4) bioplex_WMM |
| SYNE4 | FZD6 | 0.101 | 0.364 | bioplex (SYNE4) bioplex_WMM |
| KLC4 | KLC3 | 0.062 | 0.34 | hein_WMM bioplex_WMM boldt youn_WMM hein (KLC3,KLC4) boldt_WMM |
| KIF5C | KIF5B | 0.03 | 0.233 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| KIF5B | KLC3 | 0.022 | 0.195 | hein_WMM bioplex_WMM boldt youn_WMM hein (KIF5B,KLC3) boldt_WMM |
| KIF5C | KLC3 | 0.012 | 0.15 | bioplex_WMM boldt youn_WMM boldt_WMM |
| FZD6 | KLC3 | 0.008 | 0.08 | bioplex_WMM youn_WMM WMM_only |
| KIF5B | KLC1 | 0.008 | 0.028 | hein_WMM bioplex (KLC1) bioplex_WMM Guru boldt youn_WMM hein (KIF5B,KLC1) gupta_WMM fraction boldt_WMM |
| KIF5C | FZD6 | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| FZD6 | KLC4 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| FZD6 | KLC2 | 0.007 | 0.009 | bioplex_WMM youn_WMM WMM_only |
| FZD6 | KIF5B | 0.007 | 0.006 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| FZD6 | KLC1 | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| KIF5C | KLC2 | 0.0 | 0.0 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KIF5C | KLC1 | 0.0 | 0.0 | bioplex (KLC1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KIF5C | KLC4 | 0.0 | 0.001 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_01759 has an average edge precision of 0.409 which is ranked 3207 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KIF5B | HuMAP2_01759 HuMAP2_03083 HuMAP2_06530 |
| KLC1 | HuMAP2_01759 HuMAP2_04729 HuMAP2_06530 |
| KIF5C | HuMAP2_01187 HuMAP2_01759 HuMAP2_06530 |
| KLC3 | HuMAP2_01759 HuMAP2_06530 HuMAP2_06981 |
| SYNE4 | HuMAP2_01187 HuMAP2_01759 HuMAP2_04729 HuMAP2_06530 HuMAP2_06720 |
| KLC4 | HuMAP2_01759 HuMAP2_03083 HuMAP2_06530 |
| KLC2 | HuMAP2_01759 HuMAP2_03083 HuMAP2_06475 HuMAP2_06530 |
| FZD6 | HuMAP2_01187 HuMAP2_01759 HuMAP2_02211 HuMAP2_04065 HuMAP2_06720 |