hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01760
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CD244 | Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) | UniProt NCBI |
| PDXDC1 | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | UniProt NCBI |
| RFTN2 | Raftlin-2 (Raft-linking protein 2) | UniProt NCBI |
| POMT1 | Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) | UniProt NCBI |
| POMT2 | Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5083633 | 4.04876825444e-05 | 0.4 | POMT1 POMT2 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 |
| REAC:R-HSA-5083629 | 4.04876825444e-05 | 0.4 | POMT1 POMT2 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 |
| HP:0040173 | 0.00046457916755 | 0.4 | POMT1 POMT2 | Abnormality of the tongue muscle |
| HP:0006888 | 0.00046457916755 | 0.4 | POMT1 POMT2 | Meningoencephalocele |
| HP:0006899 | 0.000696775152219 | 0.4 | POMT1 POMT2 | Fusion of the cerebellar hemispheres |
| HP:0012693 | 0.000696775152219 | 0.4 | POMT1 POMT2 | Abnormal thalamic size |
| HP:0012695 | 0.000696775152219 | 0.4 | POMT1 POMT2 | Decreased thalamic volume |
| KEGG:00514 | 0.000899348170684 | 0.4 | POMT1 POMT2 | Other types of O-glycan biosynthesis |
| KEGG:00515 | 0.000899348170684 | 0.4 | POMT1 POMT2 | Mannose type O-glycan biosynthesis |
| HP:0030099 | 0.00167158658755 | 0.4 | POMT1 POMT2 | Reduced muscle fiber alpha dystroglycan |
| HP:0004637 | 0.00208920255027 | 0.4 | POMT1 POMT2 | Decreased cervical spine mobility |
| HP:0006955 | 0.00208920255027 | 0.4 | POMT1 POMT2 | Olivopontocerebellar hypoplasia |
| HP:0030046 | 0.00208920255027 | 0.4 | POMT1 POMT2 | Hypoglycosylation of alpha-dystroglycan |
| HP:0030112 | 0.00208920255027 | 0.4 | POMT1 POMT2 | Abnormal muscle fiber alpha dystroglycan |
| HP:0007291 | 0.0025531267598 | 0.4 | POMT1 POMT2 | Posterior fossa cyst |
| HP:0002189 | 0.00361982515692 | 0.4 | POMT1 POMT2 | Excessive daytime sleepiness |
| HP:0007015 | 0.00361982515692 | 0.4 | POMT1 POMT2 | Poor gross motor coordination |
| HP:0031882 | 0.00422256197273 | 0.4 | POMT1 POMT2 | Agyria |
| HP:0007033 | 0.00422256197273 | 0.4 | POMT1 POMT2 | Cerebellar dysplasia |
| HP:0007260 | 0.00487153229182 | 0.4 | POMT1 POMT2 | Type II lissencephaly |
| HP:0000659 | 0.00487153229182 | 0.4 | POMT1 POMT2 | Peters anomaly |
| HP:0003707 | 0.00487153229182 | 0.4 | POMT1 POMT2 | Calf muscle pseudohypertrophy |
| HP:0008443 | 0.00487153229182 | 0.4 | POMT1 POMT2 | Spinal deformities |
| HP:0012400 | 0.00709565752293 | 0.4 | POMT1 POMT2 | Abnormal aldolase level |
| HP:0000557 | 0.00792937512816 | 0.4 | POMT1 POMT2 | Buphthalmos |
| HP:0003741 | 0.00880923289202 | 0.4 | POMT1 POMT2 | Congenital muscular dystrophy |
| HP:0007731 | 0.00973521215689 | 0.4 | POMT1 POMT2 | Chorioretinal dysplasia |
| HP:0010508 | 0.0107072942689 | 0.4 | POMT1 POMT2 | Metatarsus valgus |
| HP:0007973 | 0.0107072942689 | 0.4 | POMT1 POMT2 | Retinal dysplasia |
| HP:0007227 | 0.0107072942689 | 0.4 | POMT1 POMT2 | Macrogyria |
| HP:0003327 | 0.011725460578 | 0.4 | POMT1 POMT2 | Axial muscle weakness |
| HP:0030089 | 0.0127896924378 | 0.4 | POMT1 POMT2 | Abnormal muscle fiber protein expression |
| HP:0010663 | 0.0127896924378 | 0.4 | POMT1 POMT2 | Abnormality of thalamus morphology |
| HP:0002085 | 0.0150562782431 | 0.4 | POMT1 POMT2 | Occipital encephalocele |
| HP:0012110 | 0.0175069025895 | 0.4 | POMT1 POMT2 | Hypoplasia of the pons |
| REAC:R-HSA-3906995 | 0.017778070678 | 0.4 | POMT1 POMT2 | Diseases associated with O-glycosylation of proteins |
| HP:0007204 | 0.0188011826397 | 0.4 | POMT1 POMT2 | Diffuse white matter abnormalities |
| HP:0006957 | 0.0188011826397 | 0.4 | POMT1 POMT2 | Loss of ability to walk |
| HP:0001090 | 0.0201414164419 | 0.4 | POMT1 POMT2 | Abnormally large globe |
| HP:0030197 | 0.0201414164419 | 0.4 | POMT1 POMT2 | Fatigable weakness of skeletal muscles |
| HP:0000485 | 0.0229596708254 | 0.4 | POMT1 POMT2 | Megalocornea |
| HP:0001460 | 0.0291468055875 | 0.4 | POMT1 POMT2 | Aplasia/Hypoplasia involving the skeletal musculature |
| HP:0001087 | 0.0308081945037 | 0.4 | POMT1 POMT2 | Developmental glaucoma |
| HP:0045040 | 0.0325153883173 | 0.4 | POMT1 POMT2 | Abnormal lactate dehydrogenase activity |
| HP:0007361 | 0.0325153883173 | 0.4 | POMT1 POMT2 | Abnormality of the pons |
| HP:0002275 | 0.0360671162807 | 0.4 | POMT1 POMT2 | Poor motor coordination |
| HP:0000413 | 0.0360671162807 | 0.4 | POMT1 POMT2 | Atresia of the external auditory canal |
| HP:0002505 | 0.0379116132621 | 0.4 | POMT1 POMT2 | Progressive inability to walk |
| HP:0002435 | 0.0417377803311 | 0.4 | POMT1 POMT2 | Meningocele |
| HP:0008981 | 0.0437194132729 | 0.4 | POMT1 POMT2 | Calf muscle hypertrophy |
| GO:0004169 | 0.0450641792523 | 0.4 | POMT1 POMT2 | dolichyl-phosphate-mannose-protein mannosyltransferase activity |
| HP:0008968 | 0.0457467210618 | 0.4 | POMT1 POMT2 | Muscle hypertrophy of the lower extremities |
| REAC:R-HSA-5173105 | 0.0476518941102 | 0.4 | POMT1 POMT2 | O-linked glycosylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CD244 | POMT2 | 0.835 | 0.779 | bioplex (CD244) bioplex_WMM |
| POMT1 | CD244 | 0.395 | 0.555 | bioplex (CD244) bioplex_WMM |
| PDXDC1 | CD244 | 0.042 | 0.27 | bioplex (CD244) bioplex_WMM |
| POMT2 | RFTN2 | 0.024 | 0.211 | bioplex (RFTN2) bioplex_WMM |
| POMT1 | RFTN2 | 0.014 | 0.141 | bioplex (RFTN2) bioplex_WMM |
| POMT1 | POMT2 | 0.01 | 0.117 | bioplex_WMM WMM_only |
| PDXDC1 | POMT2 | 0.006 | 0.005 | bioplex_WMM WMM_only |
| PDXDC1 | POMT1 | 0.006 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01760 has an average edge precision of 0.26 which is ranked 5231 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CD244 | HuMAP2_01309 HuMAP2_01760 HuMAP2_02725 HuMAP2_02850 HuMAP2_04962 |
| PDXDC1 | HuMAP2_01309 HuMAP2_01760 HuMAP2_02725 |
| RFTN2 | HuMAP2_01760 HuMAP2_02377 |
| POMT1 | HuMAP2_01309 HuMAP2_01760 HuMAP2_02725 |
| POMT2 | HuMAP2_01760 HuMAP2_02377 HuMAP2_02725 HuMAP2_02850 |