hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01771
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBBP4 | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | UniProt NCBI |
| RBBP7 | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | UniProt NCBI |
| MTA1 | Metastasis-associated protein MTA1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:889 | 2.25356268047e-09 | 1.0 | MTA1 RBBP4 RBBP7 | MTA1-HDAC core complex |
| CORUM:886 | 4.50712536095e-09 | 1.0 | MTA1 RBBP4 RBBP7 | MTA1 complex |
| CORUM:587 | 1.26199510107e-08 | 1.0 | MTA1 RBBP4 RBBP7 | NuRD.1 complex |
| CORUM:282 | 1.26199510107e-07 | 1.0 | MTA1 RBBP4 RBBP7 | SNF2h-cohesin-NuRD complex |
| CORUM:632 | 1.53242262272e-07 | 1.0 | MTA1 RBBP4 RBBP7 | Anti-HDAC2 complex |
| WP:WP4320 | 5.00468323191e-07 | 1.0 | MTA1 RBBP4 RBBP7 | The effect of progerin on the involved genes in Hutchinson-Gilford Progeria Syndrome |
| REAC:R-HSA-73762 | 7.29021391195e-06 | 1.0 | MTA1 RBBP4 RBBP7 | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-8943724 | 1.3155205616e-05 | 1.0 | MTA1 RBBP4 RBBP7 | Regulation of PTEN gene transcription |
| CORUM:919 | 2.01342304124e-05 | 0.666666666667 | RBBP7 RBBP4 | hNURF complex |
| CORUM:100 | 2.01342304124e-05 | 0.666666666667 | RBBP7 RBBP4 | hNURF complex |
| REAC:R-HSA-427389 | 3.03590314156e-05 | 1.0 | MTA1 RBBP4 RBBP7 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| CORUM:3048 | 3.35555483123e-05 | 0.666666666667 | RBBP7 RBBP4 | mSin3A complex |
| CORUM:105 | 3.35555483123e-05 | 0.666666666667 | RBBP7 RBBP4 | Polycomb repressive complex 2 (PRC 2) |
| GO:0090545 | 4.13224520905e-05 | 1.0 | MTA1 RBBP4 RBBP7 | CHD-type complex |
| GO:0016581 | 4.13224520905e-05 | 1.0 | MTA1 RBBP4 RBBP7 | NuRD complex |
| REAC:R-HSA-3214815 | 5.83423927535e-05 | 1.0 | MTA1 RBBP4 RBBP7 | HDACs deacetylate histones |
| CORUM:695 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | SIN3-HDAC-SAP30-ARID4 complex |
| CORUM:732 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | SIN3 complex |
| CORUM:698 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | SIN3-HDAC-SAP30-ARID4 complex |
| CORUM:54 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | SIN3 complex |
| CORUM:61 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | Mi2/NuRD complex |
| CORUM:596 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | SIN3-HDAC-SAP30-ARID4 complex |
| CORUM:614 | 7.04603414803e-05 | 0.666666666667 | MTA1 RBBP4 | NRD complex (Nucleosome remodeling and deacetylation complex) |
| CORUM:650 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | HDAC2-asscociated core complex |
| CORUM:283 | 7.04603414803e-05 | 0.666666666667 | RBBP7 RBBP4 | Sin3 complex |
| REAC:R-HSA-5250913 | 8.18733958818e-05 | 1.0 | MTA1 RBBP4 RBBP7 | Positive epigenetic regulation of rRNA expression |
| CORUM:62 | 9.39429153233e-05 | 0.666666666667 | RBBP7 RBBP4 | MeCP1 complex |
| CORUM:696 | 9.39429153233e-05 | 0.666666666667 | RBBP7 RBBP4 | BRMS1-SIN3-HDAC complex |
| CORUM:591 | 9.39429153233e-05 | 0.666666666667 | RBBP7 RBBP4 | SAP complex (Sin3-associated protein complex) |
| CORUM:888 | 9.39429153233e-05 | 0.666666666667 | RBBP7 RBBP4 | MTA2 complex |
| REAC:R-HSA-73854 | 9.4385677915e-05 | 1.0 | MTA1 RBBP4 RBBP7 | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 9.70320053332e-05 | 1.0 | MTA1 RBBP4 RBBP7 | RNA Polymerase I Transcription |
| WP:WP2916 | 0.000115031710136 | 0.666666666667 | RBBP7 RBBP4 | Interactome of polycomb repressive complex 2 (PRC2) |
| CORUM:592 | 0.000120778339722 | 0.666666666667 | RBBP7 RBBP4 | SAP complex (Sin3-associated protein complex) |
| CORUM:685 | 0.000120778339722 | 0.666666666667 | RBBP7 RBBP4 | MeCP1 complex |
| CORUM:659 | 0.000120778339722 | 0.666666666667 | RBBP7 RBBP4 | MeCP1 complex |
| CORUM:649 | 0.000120778339722 | 0.666666666667 | RBBP7 RBBP4 | HDAC1-associated core complex cII |
| CORUM:646 | 0.000120778339722 | 0.666666666667 | RBBP7 RBBP4 | HDAC1-associated protein complex |
| CORUM:738 | 0.000120778339722 | 0.666666666667 | RBBP7 RBBP4 | SIN3-ING1b complex I |
| CORUM:743 | 0.000150966163965 | 0.666666666667 | RBBP7 RBBP4 | SIN3-SAP25 complex |
| GO:0090568 | 0.000160839698137 | 1.0 | MTA1 RBBP4 RBBP7 | nuclear transcriptional repressor complex |
| REAC:R-HSA-6807070 | 0.000180286113329 | 1.0 | MTA1 RBBP4 RBBP7 | PTEN Regulation |
| CORUM:691 | 0.000184505937338 | 0.666666666667 | RBBP7 RBBP4 | SIN3-SAP25 complex |
| REAC:R-HSA-212165 | 0.000228431198544 | 1.0 | MTA1 RBBP4 RBBP7 | Epigenetic regulation of gene expression |
| CORUM:2851 | 0.000261639528628 | 0.666666666667 | RBBP7 RBBP4 | ING2 complex |
| CORUM:739 | 0.000402468266231 | 0.666666666667 | RBBP7 RBBP4 | SIN3-ING1b complex II |
| CORUM:2721 | 0.000513101066766 | 0.666666666667 | RBBP7 RBBP4 | HCF-1 complex |
| REAC:R-HSA-1257604 | 0.000842184933696 | 1.0 | MTA1 RBBP4 RBBP7 | PIP3 activates AKT signaling |
| CORUM:1257 | 0.00126709356127 | 0.666666666667 | RBBP7 RBBP4 | ALL-1 supercomplex |
| REAC:R-HSA-9006925 | 0.00134762672661 | 1.0 | MTA1 RBBP4 RBBP7 | Intracellular signaling by second messengers |
| REAC:R-HSA-4839726 | 0.00144234915262 | 1.0 | MTA1 RBBP4 RBBP7 | Chromatin organization |
| REAC:R-HSA-3247509 | 0.00144234915262 | 1.0 | MTA1 RBBP4 RBBP7 | Chromatin modifying enzymes |
| REAC:R-HSA-6804758 | 0.00290884705451 | 0.666666666667 | RBBP7 RBBP4 | Regulation of TP53 Activity through Acetylation |
| WP:WP2446 | 0.00357470816736 | 0.666666666667 | RBBP7 RBBP4 | Retinoblastoma Gene in Cancer |
| GO:0000118 | 0.00360649647245 | 1.0 | MTA1 RBBP4 RBBP7 | histone deacetylase complex |
| REAC:R-HSA-8953750 | 0.00375073705264 | 0.666666666667 | RBBP7 RBBP4 | Transcriptional Regulation by E2F6 |
| GO:0017053 | 0.00435066388439 | 1.0 | MTA1 RBBP4 RBBP7 | transcriptional repressor complex |
| GO:0070603 | 0.00664337883609 | 1.0 | MTA1 RBBP4 RBBP7 | SWI/SNF superfamily-type complex |
| GO:1904949 | 0.00746165420606 | 1.0 | MTA1 RBBP4 RBBP7 | ATPase complex |
| REAC:R-HSA-3214841 | 0.0165866686159 | 0.666666666667 | RBBP7 RBBP4 | PKMTs methylate histone lysines |
| REAC:R-HSA-212300 | 0.0170598073203 | 0.666666666667 | RBBP7 RBBP4 | PRC2 methylates histones and DNA |
| REAC:R-HSA-774815 | 0.0170598073203 | 0.666666666667 | RBBP7 RBBP4 | Nucleosome assembly |
| REAC:R-HSA-606279 | 0.0170598073203 | 0.666666666667 | RBBP7 RBBP4 | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-73886 | 0.0385024292001 | 0.666666666667 | RBBP7 RBBP4 | Chromosome Maintenance |
| REAC:R-HSA-5619507 | 0.0436663131868 | 0.666666666667 | RBBP7 RBBP4 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.0436663131868 | 0.666666666667 | RBBP7 RBBP4 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-2559580 | 0.0491532487396 | 0.666666666667 | RBBP7 RBBP4 | Oxidative Stress Induced Senescence |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MTA1 | RBBP4 | 1.0 | 0.949 | hein_WMM bioplex (MTA1) bioplex_WMM Guru youn_WMM hein (MTA1) gupta_WMM fraction boldt_WMM |
| RBBP4 | RBBP7 | 1.0 | 0.949 | hein_WMM bioplex (RBBP7) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MTA1 | RBBP7 | 0.999 | 0.949 | hein_WMM bioplex (MTA1,RBBP7) bioplex_WMM youn_WMM hein (MTA1) gupta_WMM fraction boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_01771 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RBBP4 | HuMAP2_01771 HuMAP2_02289 HuMAP2_02937 HuMAP2_03645 HuMAP2_04544 HuMAP2_06754 |
| RBBP7 | HuMAP2_01771 HuMAP2_02229 HuMAP2_02937 HuMAP2_06754 |
| MTA1 | HuMAP2_01771 HuMAP2_02937 HuMAP2_03310 HuMAP2_04282 HuMAP2_06754 |