hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01781
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CEP290 | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | UniProt NCBI |
| IQCB1 | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6597 | 1.67592346237e-06 | 1.0 | CEP290 IQCB1 | CEP290-IQCB1 complex |
| HP:0001141 | 0.00108531561999 | 1.0 | CEP290 IQCB1 | Severely reduced visual acuity |
| HP:0000090 | 0.00210384258643 | 1.0 | CEP290 IQCB1 | Nephronophthisis |
| HP:0002612 | 0.00287525153479 | 1.0 | CEP290 IQCB1 | Congenital hepatic fibrosis |
| HP:0100957 | 0.00315910331233 | 1.0 | CEP290 IQCB1 | Abnormal renal medulla morphology |
| HP:0008209 | 0.00392717282801 | 1.0 | CEP290 IQCB1 | Premature ovarian insufficiency |
| HP:0010579 | 0.00611116179869 | 1.0 | CEP290 IQCB1 | Cone-shaped epiphysis |
| HP:0031066 | 0.00694601996791 | 1.0 | CEP290 IQCB1 | Abnormal ovarian physiology |
| HP:0003774 | 0.00694601996791 | 1.0 | CEP290 IQCB1 | Stage 5 chronic kidney disease |
| REAC:R-HSA-5620912 | 0.0074829982595 | 1.0 | CEP290 IQCB1 | Anchoring of the basal body to the plasma membrane |
| WP:WP4352 | 0.0083331540652 | 1.0 | CEP290 IQCB1 | Ciliary landscape |
| HP:0012622 | 0.0105526072589 | 1.0 | CEP290 IQCB1 | Chronic kidney disease |
| HP:0000529 | 0.0116412623116 | 1.0 | CEP290 IQCB1 | Progressive visual loss |
| HP:0002084 | 0.0119217746565 | 1.0 | CEP290 IQCB1 | Encephalocele |
| HP:0011815 | 0.0119217746565 | 1.0 | CEP290 IQCB1 | Cephalocele |
| HP:0000563 | 0.0127833482871 | 1.0 | CEP290 IQCB1 | Keratoconus |
| HP:0100692 | 0.0136749768118 | 1.0 | CEP290 IQCB1 | Increased corneal curvature |
| HP:0100689 | 0.0145966602306 | 1.0 | CEP290 IQCB1 | Decreased corneal thickness |
| HP:0011486 | 0.0149105669023 | 1.0 | CEP290 IQCB1 | Abnormality of corneal thickness |
| HP:0001395 | 0.0161995879155 | 1.0 | CEP290 IQCB1 | Hepatic fibrosis |
| REAC:R-HSA-5617833 | 0.0304096312248 | 1.0 | CEP290 IQCB1 | Cilium Assembly |
| HP:0000510 | 0.0329602005208 | 1.0 | CEP290 IQCB1 | Rod-cone dystrophy |
| HP:0000512 | 0.0368205846953 | 1.0 | CEP290 IQCB1 | Abnormal electroretinogram |
| HP:0004374 | 0.0485386539584 | 1.0 | CEP290 IQCB1 | Hemiplegia/hemiparesis |
| HP:0000572 | 0.0485386539584 | 1.0 | CEP290 IQCB1 | Visual loss |
| HP:0004727 | 0.0497341708567 | 0.5 | CEP290 | Impaired renal concentrating ability |
| HPA:038020_21 | 0.0499140284799 | 0.5 | IQCB1 | retina; cells in photoreceptor layer [Approved,Low] |
| HPA:038020_22 | 0.0499140284799 | 0.5 | IQCB1 | retina; cells in photoreceptor layer [Approved,Medium] |
| CORUM:6594 | 0.0499173803268 | 0.5 | CEP290 | CCP110-CEP290 complex |
| CORUM:6598 | 0.0499173803268 | 0.5 | CEP290 | CC2D2A-CEP290 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CEP290 | IQCB1 | 1.0 | 0.949 | hein_WMM bioplex (IQCB1) bioplex_WMM gupta (CEP290) boldt (IQCB1) hein (CEP290) gupta_WMM boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_01781 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CEP290 | HuMAP2_01781 |
| IQCB1 | HuMAP2_01781 HuMAP2_03658 |