hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01782
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPGRIP1L | Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) | UniProt NCBI |
| GKAP1 | G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa) | UniProt NCBI |
| RPGR | X-linked retinitis pigmentosa GTPase regulator | UniProt NCBI |
| NEK4 | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | UniProt NCBI |
| NPHP4 | Nephrocystin-4 (Nephroretinin) | UniProt NCBI |
| NPHP1 | Nephrocystin-1 (Juvenile nephronophthisis 1 protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6381 | 2.51655344529e-05 | 0.333333333333 | NPHP4 NPHP1 | NPHP1-NPHP4-BCAR1 complex |
| CORUM:6681 | 5.0322056017e-05 | 0.333333333333 | RPGRIP1L NPHP4 | DVL2-INVS-NPHP4-RPGRIP1L complex |
| WP:WP4656 | 9.23806515429e-05 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Joubert Syndrome |
| HP:0000090 | 0.000143381531621 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Nephronophthisis |
| HP:0002612 | 0.000230325766317 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Congenital hepatic fibrosis |
| HP:0100957 | 0.000265636855275 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Abnormal renal medulla morphology |
| HP:0000556 | 0.000543279193151 | 0.666666666667 | NPHP4 RPGRIP1L NPHP1 RPGR | Retinal dystrophy |
| REAC:R-HSA-5620912 | 0.000812902380283 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Anchoring of the basal body to the plasma membrane |
| HP:0000108 | 0.00210158306671 | 0.333333333333 | NPHP4 NPHP1 | Renal corticomedullary cysts |
| HP:0001395 | 0.00311982866128 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Hepatic fibrosis |
| HP:0030760 | 0.00337633448894 | 0.333333333333 | NPHP4 NPHP1 | Renal fibrosis |
| HP:0005576 | 0.00337633448894 | 0.333333333333 | NPHP4 NPHP1 | Tubulointerstitial fibrosis |
| REAC:R-HSA-5617833 | 0.00661628360681 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Cilium Assembly |
| HP:0000092 | 0.00899388668352 | 0.333333333333 | NPHP4 NPHP1 | Tubular atrophy |
| HP:0000510 | 0.00903835350739 | 0.5 | RPGR NPHP1 NPHP4 | Rod-cone dystrophy |
| HP:0000103 | 0.0142301190129 | 0.333333333333 | NPHP4 NPHP1 | Polyuria |
| HP:0000518 | 0.015733501449 | 0.666666666667 | NPHP4 RPGRIP1L NPHP1 RPGR | Cataract |
| HP:0000517 | 0.0176975810126 | 0.666666666667 | NPHP4 RPGRIP1L NPHP1 RPGR | Abnormality of the lens |
| GO:1903348 | 0.020283420769 | 0.333333333333 | NPHP4 NPHP1 | positive regulation of bicellular tight junction assembly |
| REAC:R-HSA-1852241 | 0.0204484407303 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Organelle biogenesis and maintenance |
| HP:0030082 | 0.0262553193116 | 0.333333333333 | NPHP4 NPHP1 | Abnormal drinking behavior |
| HP:0001959 | 0.0262553193116 | 0.333333333333 | NPHP4 NPHP1 | Polydipsia |
| HP:0000107 | 0.028507232728 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Renal cyst |
| HP:0000479 | 0.0322029678499 | 0.666666666667 | NPHP4 RPGRIP1L NPHP1 RPGR | Abnormal retinal morphology |
| GO:0035869 | 0.0353486827187 | 0.5 | RPGRIP1L NPHP1 NPHP4 | ciliary transition zone |
| HP:0002419 | 0.0419110169922 | 0.333333333333 | RPGRIP1L NPHP1 | Molar tooth sign on MRI |
| HP:0001425 | 0.0465289476346 | 0.5 | RPGRIP1L NPHP1 NPHP4 | Heterogeneous |
| HP:0012590 | 0.0470489782673 | 0.333333333333 | NPHP4 NPHP1 | Abnormal urine output |
| CORUM:6660 | 0.0499726005494 | 0.166666666667 | NPHP4 | LATS1-NPHP4 complex |
| CORUM:6342 | 0.0499726005494 | 0.166666666667 | NPHP4 | Jade-1-NPHP4 complex |
| CORUM:6750 | 0.0499726005494 | 0.166666666667 | NPHP1 | AHI1-NPHP1 heterotetramer |
| CORUM:6743 | 0.0499726005494 | 0.166666666667 | NPHP1 | AHI1-NPHP1 heterodimer |
| CORUM:6600 | 0.0499726005494 | 0.166666666667 | NPHP1 | NPHP1-PKD1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPGRIP1L | RPGR | 1.0 | 0.949 | bioplex (RPGR) bioplex_WMM gupta (RPGR,RPGRIP1L) boldt (RPGRIP1L) boldt_WMM |
| RPGR | NPHP4 | 0.998 | 0.943 | bioplex (RPGR) bioplex_WMM gupta (RPGR) boldt gupta_WMM boldt_WMM |
| NPHP4 | NPHP1 | 0.946 | 0.857 | bioplex_WMM gupta (NPHP1,NPHP4) boldt (NPHP4) gupta_WMM boldt_WMM |
| RPGRIP1L | NPHP4 | 0.912 | 0.835 | bioplex_WMM gupta (RPGRIP1L) boldt (RPGRIP1L) youn_WMM gupta_WMM boldt_WMM |
| RPGRIP1L | GKAP1 | 0.246 | 0.469 | gupta (RPGRIP1L) boldt (RPGRIP1L) youn_WMM boldt_WMM |
| RPGRIP1L | NEK4 | 0.203 | 0.453 | gupta (RPGRIP1L) boldt (RPGRIP1L) youn_WMM boldt_WMM |
| RPGRIP1L | NPHP1 | 0.185 | 0.439 | bioplex_WMM gupta (NPHP1,RPGRIP1L) boldt (RPGRIP1L) gupta_WMM boldt_WMM |
| RPGR | NPHP1 | 0.039 | 0.263 | bioplex (RPGR) bioplex_WMM boldt gupta_WMM boldt_WMM |
| NEK4 | RPGR | 0.008 | 0.011 | boldt gupta_WMM boldt_WMM |
| NEK4 | NPHP4 | 0.007 | 0.003 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| NEK4 | GKAP1 | 0.007 | 0.005 | boldt youn_WMM gupta_WMM boldt_WMM |
| NEK4 | NPHP1 | 0.007 | 0.005 | boldt gupta_WMM boldt_WMM |
| NPHP1 | GKAP1 | 0.007 | 0.004 | boldt gupta_WMM boldt_WMM |
| RPGR | GKAP1 | 0.007 | 0.006 | boldt gupta_WMM boldt_WMM |
| NPHP4 | GKAP1 | 0.007 | 0.003 | boldt gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_01782 has an average edge precision of 0.35 which is ranked 3971 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPGRIP1L | HuMAP2_00333 HuMAP2_01782 HuMAP2_05152 |
| GKAP1 | HuMAP2_00333 HuMAP2_01782 |
| RPGR | HuMAP2_00333 HuMAP2_00699 HuMAP2_00864 HuMAP2_01782 HuMAP2_04078 HuMAP2_05152 |
| NEK4 | HuMAP2_00333 HuMAP2_01782 HuMAP2_02926 HuMAP2_04021 |
| NPHP4 | HuMAP2_00333 HuMAP2_01782 HuMAP2_05152 |
| NPHP1 | HuMAP2_00333 HuMAP2_01782 HuMAP2_05152 |